Harley McAdams
Academic Appointments
Appointment
Organization
Professor (Research)
Member
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Honors & Awards
Title
Organization
Date(s)
Fellow
American Academy of Microbiologists
2006
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
PhD
Rice University
Physics
1967
MA
Rice University
Physics
1965
MS
U. Illinois (Urbana)
Physics
1962
BS
Texas A&M
Physics
1960
Web Site Links
Research/Lab website:
Personal Web site
Research Interests
We are focused on understanding the nature of bacterial genetic regulation. We use a variety of tools: gene expression microarrays, advanced techniques of fluorescence and electron microscopy, and a broad range of computational tools for bioinformatics and modeling.
The marine bacterium, Caulobacter crescentus, is our primary model organism. The graduate students in the McAdams group include Electrical Engineering, Physics, and Physical Chemistry students who are interested in biologically focused research. We work closely with geneticists and biochemists who are graduate students and postdoctoral fellows in Lucy Shapiro's group to bring a multi-disciplinary approach to the analysis of bacterial regulation and control.
Our interests range far beyond "conventional" approaches to genetic regulation to include the effects of dynamic spatial and temporal positioning of regulatory proteins and the regulatory effects working through the dynamic three-dimensional organization of the chromosome in the dividing cell. We are exploring how regulatory molecules are dynamically localized to particular cell positions and how this localization is integrated into the control mechanisms of the cell.
The marine bacterium, Caulobacter crescentus, is our primary model organism. The graduate students in the McAdams group include Electrical Engineering, Physics, and Physical Chemistry students who are interested in biologically focused research. We work closely with geneticists and biochemists who are graduate students and postdoctoral fellows in Lucy Shapiro's group to bring a multi-disciplinary approach to the analysis of bacterial regulation and control.
Our interests range far beyond "conventional" approaches to genetic regulation to include the effects of dynamic spatial and temporal positioning of regulatory proteins and the regulatory effects working through the dynamic three-dimensional organization of the chromosome in the dividing cell. We are exploring how regulatory molecules are dynamically localized to particular cell positions and how this localization is integrated into the control mechanisms of the cell.
Publications
- McGrath PT, Lee H, Zhang L, Iniesta AA, Hottes AK, Tan MH, Hillson NJ, Hu P, Shapiro L, McAdams HH "High-throughput identification of transcription start sites, conserved promoter motifs and predicted regulons." Nat Biotechnol 2007; More »
- Collier J, McAdams HH, Shapiro L "A DNA methylation ratchet governs progression through a bacterial cell cycle." Proc Natl Acad Sci U S A 2007; 104: 43: 17111-6 More »
- Laub MT, Shapiro L, McAdams HH "Systems biology of caulobacter." Annu Rev Genet 2007; 41: 429-41 More »
- Chen JC, Hottes AK, McAdams HH, McGrath PT, Viollier PH, Shapiro L "Cytokinesis signals truncation of the PodJ polarity factor by a cell cycle-regulated protease." EMBO J 2006; More »
- McGrath PT, Iniesta AA, Ryan KR, Shapiro L, McAdams HH "A dynamically localized protease complex and a polar specificity factor control a cell cycle master regulator." Cell 2006; 124: 3: 535-47 More »
38 publications: view full list