Gerald Crabtree
Academic Appointments
- Professor, Pathology
- Professor, Developmental Biology
- Member, Bio-X
- Member, Cancer Center
Contact Information
- Academic
Offices
Personal Information Email Tel (650) 723-3685 Tel (650) 723-8391Administrative Contact Penny Brueggemann Administrative Assistant Email Tel Work 650 723 3685
Professional Snapshot
Postdoctoral Advisees
Oliver Bell , Emily Dykhuizen , Laura Elias , Diana Hargreaves , Hamilton Courtney Hodges , Andrew Koh , Fu-Sen Liang , Aryaman Shalizi , Benjamin Stanton , Andrew Yoo
Graduate & Fellowship Program Affiliations
Web Site Links
Scientific Focus
Current Research Interests
We are interested in the role of chromatin regulation in stem cells and have recently discovered a stem cell specific chromatin remodeling complex which plays an essential role in the formation and function of stem cells. We hope to understand how this complex functions over the genome of stem cells and its potential roles in the formation of induced pluripotent cells.
We are also interested in the mechanisms by which signals through Ca2+, calcineurin and NFATc proteins regulate development and morphogenesis in vertebrates. We hope to define the many roles of this pathway in development and disease. For example, this pathway is critical for immunologic function and transplant rejection, for the pathogenesis of diabetes, congential heart defects, Down Syndrome and perhaps osteoporesis. In addition to defining the full range of function of the pathway we hope to understand how the pathway might be regulated for therapeutic purposes.
Finally, we are developing new ways of making conditional alleles of mammalian genes using synthetic ligands that we hope will bring about a new fusion of biochemical and genetic approaches to understanding and controlling fundamental biologic processes.
Publications
- Understanding the words of chromatin regulation. Cell. 2009; (2): 200-6
- Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science. 2009; (5914): 651-4
- An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A. 2009; (13): 5181-6
- An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proc Natl Acad Sci U S A. 2009; (13): 5187-91
- ATP-dependent chromatin remodeling in neural development. Curr Opin Neurobiol. 2009; (2): 120-6
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