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George YangAcademic Appointments
Appointment
Organization
Assistant Professor - Med Center Line
Surgery ;
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Honors & Awards
Title
Organization
Date(s)
Resident Research Scholarship
American College of Surgeons
1996-1998
Faculty Research Fellow
American College of Surgeons
2002-2004
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
BA
Northwestern University
biological sciences
1985
MD
Northwestern Univ Med School
medicine
1994
PhD
Univ of Illinois Coll of Med
molecular genetics
1993
Postdoctoral Advisees
Paris Butler,
Christine Ham
Research Interests
We are broadly interested in understanding the response to injury by studying the cellular responses to stress. These data will have pertinence to the study of wound healing and critical care medicine. Many of the molecular pathways involved in the response to injury have protective or regenerative functions. The ultimate goal of these studies is to better understand how organisms heal and repair injury with an eye towards applying this knowledge in regenerative medicine strategies.
Among the pathologies we are interested in are keloids, an example of excessive skin wound healing. We are currently working on defining molecular differences in the response to injury in keloid versus normal skin cells. Another project looks at the role of the matricellular protein, Del1, in the injury response. And finally, we are interested in how cells respond to hypoxia, a physiologic condition encountered in wound environment, and how this relates to tissue damage and repair.
My clinical research work examines the use stereotactic radiosurgery in the treatment of intraabdominal tumors. Currently, I am involved in clinical trials for the use of stereotactic radiosurgery for certain tumors of the liver and pancreas.
Among the pathologies we are interested in are keloids, an example of excessive skin wound healing. We are currently working on defining molecular differences in the response to injury in keloid versus normal skin cells. Another project looks at the role of the matricellular protein, Del1, in the injury response. And finally, we are interested in how cells respond to hypoxia, a physiologic condition encountered in wound environment, and how this relates to tissue damage and repair.
My clinical research work examines the use stereotactic radiosurgery in the treatment of intraabdominal tumors. Currently, I am involved in clinical trials for the use of stereotactic radiosurgery for certain tumors of the liver and pancreas.
Community and International Work
- Hospital de la Familia, Nuevo Progresso, Guatemala More »
Publications
- Hsu GP, Mathy JA, Wang Z, Xia W, Sakamoto G, Kundu R, Longaker MT, Quertermous T, Yang GP "Increased Rate of Hair Regrowth in Mice with Constitutive Overexpression of Del1." J Surg Res 2007; More »
- Xia W, Kong W, Wang Z, Phan TT, Lim IJ, Longaker MT, Yang GP "Increased CCN2 Transcription in Keloid Fibroblasts Requires Cooperativity Between AP-1 and SMAD Binding Sites." Ann Surg 2007; 246: 5: 886-895 More »
- Butler PD, Ly DP, Longaker MT, Yang GP "Use of organotypic coculture to study keloid biology." Am J Surg 2007; More »
- Yang GP, Soetikno RM "Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine model." Gut 2007; 56: 3: 313-4 More »
- Chang ST, Goodman KA, Yang GP, Koong AC "Stereotactic body radiotherapy for unresectable pancreatic cancer." Front Radiat Ther Oncol 2007; 40: 386-94 More »
20 publications: view full list
