Fredric Kraemer

Clinical Focus

• Endocrinology / Diabetes
• Lipid Metabolism Disorders
• Endocrinology and Metabolism

Administrative Appointments

• Associate Chief of Staff for Research and Development, VA Palo Alto Health Care System (2002 - 2007)
• Chief, Division of Endocrinology, Gerontology and Metabolism, Stanford University (2002 - present)

Honors and Awards

• Special Emphasis Research Career Award, NIH (1982-1987)
• Mellon Foundation Fellow, Stanford University (1983-1984)
• Hume Faculty Scholar, Stanford University (1984-1988)
• SmithKline Beecham Junior Faculty Award In Diabetes, SmithKline Beecham (1998)
• Stanford University Professorship in Endocrinology, Stanford University (2002)

Professional Education

Postdoctoral Advisees

Aiqin Cao , Bin Dong , Zhigang Hu , Li-Fen Liu , Masami Ueno , Minhao Wu , Weibin Xu , Syed Zaidi , Yasuo Zenimaru , Haiyan Zhang

Graduate & Fellowship Program Affiliations

• Medicine

Current Research Interests

Our research interests are in the general area of cellular lipid and lipoprotein metabolism. The work is aimed primarily at understanding the mechanisms regulating cholesterol and triglyceride accumulation in cells. We utilize a variety of techniques from cell biology, biochemistry, and molecular biology. Current research projects focus on the regulation of hormone sensitive lipase (HSL). HSL is an intracellular enzyme responsible for the cytosolic hydrolysis of intracellular triglyceride and cholesteryl esters. Thus, it has an important role in fat mobilization, but also in cholesterol metabolism. We are examining all aspects of the biology of HSL, including its mechanisms of action and its structure-function relationships in regard to adipose cell function and steroid hormone synthesis.

Clinical Trials

• Treatment of Psychotic Major Depression with Mifepristone Terminated

Publications

• Strong induction of PCSK9 gene expression through HNF1{alpha} and SREBP2: Mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters. Dong B, Wu M, Li H, Kraemer FB, Adeli K, Seidah NG, Park SW, Liu J. J Lipid Res. 2010
• Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements. Li H, Chen W, Zhou Y, Abidi P, Sharpe O, Robinson WH, Kraemer FB, Liu J. J Lipid Res. 2009; 50 (5): 820-31
• Functional interaction of hormone-sensitive lipase and perilipin in lipolysis. Shen WJ, Patel S, Miyoshi H, Greenberg AS, Kraemer FB. J Lipid Res. 2009; 50 (11): 2306-13
• Effects of hormone-sensitive lipase-disruption on cardiac energy metabolism in response to fasting and refeeding. Suzuki J, Ueno M, Uno M, Hirose Y, Zenimaru Y, Takahashi S, Osuga JI, Ishibashi S, Takahashi M, Hirose M, Yamada M, Kraemer FB, Miyamori I. Am J Physiol Endocrinol Metab. 2009
• Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice. Ueno M, Suzuki J, Zenimaru Y, Takahashi S, Koizumi T, Noriki S, Yamaguchi O, Otsu K, Shen WJ, Kraemer FB, Miyamori I. Am J Physiol Endocrinol Metab. 2008; 294 (6): E1109-18