 |
|
|
Frank M. Longo, M.D., Ph.D.
Profile: http://med.stanford.edu/profiles/Frank_Longo/
Contact: Academic Appointments
Appointment
Organization
Professor
|
Honors & Awards
Title
Organization
Date(s)
Stanford University Fellow
Stanford University
2006-2008
Outstanding Alumnus Award
UC San Diego
2000
Associate Editor
Annals of Neurology
1994-1997
Beeson Award
American Federation for Aging Research
1995
Edwin Boldrey Award for Basic Science Research
San Francisco Neurological Society
1990
6 honors and awards: view full list
Administrative Appointments
Title
Organization
Start Year
End Year
Professor and Chair, Department of Neurology and Neurological Sciences
Stanford University
2006
-
Professor and Chair, Department of Neurology
University of North Carolina, Chapel Hill
2001
2005
Professor and Vice Chair
UC San Francisco
1999
2001
Assoc. Chief of Staff for Research and Dev.
SF, VAMC
1997
2001
Assoc. Professor and Vice Chair
UC San Francisco
1996
1999
6 appointments: view full list
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
Ph.D.
UC San Diego
Neuroscience
1983
M.D.
UC San Diego
Medicine
1981
BA
UC San Diego
Biology
1977
Research Interests
Our research group is focused on the discovery of cellular signaling mechanisms that serve as a basis for the development of novel therapeutic approaches for Alzheimer’s disease and other neurological disorders. In our Neurotrophin Program, we pioneered the development of small molecule ligands targeted to neurotrophin receptors to promote novel signaling mechanisms. Small molecule-induced activation of these mechanisms demonstrates therapeutic efficacy in models of Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, spinal cord injury, amyotrophic lateral sclerosis (ALS), HIV dementia and other areas. These novel compounds also promote neurogenesis from stem cells. In our Protein Tyrosine Phosphatase Receptor Program we have elucidated the role of protein tyrosine phosphatase (PTP) receptors in the nervous system by focusing on LAR, a prototype PTP receptor that we discovered to be expressed in the nervous system. Our studies demonstrated the first CNS and PNS phenotypes in a PTP receptor mutant mouse, discovered PTP extracellular domains responsible for their potent neurite promoting effects, found that LAR associates with Trk neurotrophin receptors to regulate their activity, showed that down regulating LAR promotes stem cell proliferation and stimulates hippocampal neurogenesis, and developed a novel approach for down regulating PTP activity. This work reveals additional candidate therapeutic targets for small molecule development.
Publications
- Chandra S, Shao J, Li JX, Li M, Longo FM, Diamond MI "A common motif targets huntingtin and the androgen receptor to the proteasome." J Biol Chem 2008; 283: 35: 23950-5 More »
- James SE, Burden H, Burgess R, Xie Y, Yang T, Massa SM, Longo FM, Lu Q "Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants." Neurotoxicology 2008; 29: 4: 605-12 More »
- Longo FM, Massa SM "Small Molecule Modulation of p75 Neurotrophin Receptor Functions." CNS Neurol Disord Drug Targets 2008; 7: 1: 63-70 More »
- Oblander SA, Ensslen-Craig SE, Longo FM, Brady-Kalnay SM "E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner." Mol Cell Neurosci 2007; 34: 3: 481-92 More »
- Longo FM, Yang T, Knowles JK, Xie Y, Moore LA, Massa SM "Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms." Curr Alzheimer Res 2007; 4: 5: 503-6 More »
73 publications: view full list
