Florian Oberstrass
Academic Appointments
- Postdoctoral Research fellow, Bioengineering
Contact Information
- Academic
Offices
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Professional Snapshot
Honors and Awards
- Chorafas Award, Dimitris N. Chorafas Foundation (2008)
- EMBO long-term fellowship, European Molecular Biology Organization (2008)
- ETH medal, ETH Zurich (2008)
- Predoctoral Fellowship, The Roche Research Foundation (2005)
Professional Education
| Doctor of Philosophy: | Eidgenossische Technische Hochschule, (2007) |
Faculty Advisor
Scientific Focus
Research Interests
Molecular motors lie at the heart of biological processes from DNA replication to vesicle transport. I seek to understand the physical mechanisms by which these nanoscale machines convert chemical energy into mechanical work. I use single molecule tracking and manipulation techniques to observe and perturb substeps in the mechanochemical cycles of individual motors. My main focus is torque generation by DNA-associated ATPases.
Publications
- Changes in dynamics of SRE-RNA on binding to the VTS1p-SAM domain studied by 13C NMR relaxation. J Am Chem Soc. 2008; (36): 12007-20
- Shape-specific recognition in the structure of the Vts1p SAM domain with RNA. Nat Struct Mol Biol. 2006; (2): 160-7
- Structure of PTB bound to RNA: specific binding and implications for splicing regulation. Science. 2005; (5743): 2054-7
- Molecular basis of messenger RNA recognition by the specific bacterial repressing clamp RsmA/CsrA. Nat Struct Mol Biol. 2007; (9): 807-13
- Solving the structure of PTB in complex with pyrimidine tracts: an NMR study of protein-RNA complexes of weak affinities. J Mol Biol. 2007; (1): 174-86
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