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Eric Sibley, M.D., Ph.D.

Academic Appointments

Contact Information

  • Clinical Offices
    Medicine Specialties Clinic 730 Welch Rd 2nd Floor Palo Alto, CA 94304
    Tel Work (650) 736-7642
    Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
  • Academic Offices
    Personal Information
    Tel (650) 723-5070
    Administrative Contact
    Carmen Kimberling Administrative Assistant Tel Work 650-725-1029
    Not for medical emergencies or patient use

Professional Snapshot

Clinical Focus

  • Gastroenterology/Nutrition/Hepatology, Pediatric
  • Pediatric Gastroenterology

Administrative Appointments

  • Editor-In-Chief, Journal of Pediatric Gastroenterology and Nutrition (2006 - 2011)
  • Chair/Vice-Chair, Growth, Development and Aging Section, American Gastroenterology Association (2007 - 2011)
  • Senator, School of Medicine Faculty Senate (2009 - 2012)
  • Associate Director (Research), Stanford Pediatric Gastroenterology Training Program (2004 - present)
  • Member, Clinical and Integrative Gastrointestinal Pathobiology Study Section, NIH (2004 - 2007)
    • View All 6administrative appointments of Eric Sibley

Honors and Awards

  • Young Faculty Investigator Award, North American Society for Pediatric Gastroenterology and Nutrition (1998)
  • Named Investigator Award, Stanford Digestive Disease Center (2002-2003)
  • Council, elected, Society for Pediatric Research (2005-2008)
  • Council, elected, American Gastroenterology Association (2007-2011)

Professional Education

Board Certification: Pediatric Gastroenterology, American Board of Pediatrics (1997)
Fellowship: SUMC - Graduate Medical Education, CA (1996)
Residency: Harbor-UCLA Medical Center, CA (1993)
Internship: Harbor-UCLA Medical Center, CA (1991)
Medical Education: Johns Hopkins University School of Medicine, MD (1990)
View All 7

Postdoctoral Advisees

Lin Fang

Graduate & Fellowship Program Affiliations

Scientific Focus

Current Research Interests

Transcriptional Regulation of Intestine-Specific Gene Expression during Gut Development and Maturation.

The mammalian gastrointestinal tract matures from a primitive tube into morphologically and functionally distinct regions during development. The mature small intestine functions in the digestion and absorption of ingested nutrients. Expression of several nutrient hydrolases is spatially restricted to distinct segments along the cephalo-caudal axis of the small intestine and is temporally regulated during postnatal maturation. Intestinal lactase, the hydrolase responsible for the digestion of lactose in milk, is expressed at highest levels in the jejunal segment of the small intestine shortly after birth and then declines dramatically just prior to weaning in most mammals.

Our research is directed towards defining the mechanisms regulating the spatial and temporal restriction of lactase gene expression during intestinal development. The normal maturational decline in lactase enzymatic activity is correlated with a decline in lactase messenger RNA levels and is transcriptionally regulated. We are currently identifying maturation-specific lactase gene cis elements and characterizing the nuclear proteins interacting with those elements in cell culture and transgenic animals. We seek to define the interactions of the lactase gene elements and nuclear factors involved in mediating transcriptional control. The overall goal is to relate these lactase control mechanisms to the broader pathways specifying acquisition of a small intestinal phenotype. We are also investigating gene transfer methods to deliver specific genes to the intestine.

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