Emmet B. Keeffe, MD

Clinical Focus

• Hepatology (Liver)
• Chronic Hepatitis B
• Chronic Hepatitis C
• Liver Transplantation
• Gastroenterology

Administrative Appointments

• Board of Directors, American Liver Foundation, Northern California Chapter (2008 - present)
• Board of Directors, Foundation for Digestive Health and Nutrition (2004 - present)
• Chief of Hepatology, Stanford University School of Medicine (2000 - 2007)
• Co-Director, Liver Transplant Program, Stanford University Medical Center (2000 - 2007)
• Chief of Clinical Gastroenterology, Stanford University School of Medicine (1995 - 2000)
View All 8administrative appointments of Emmet Keeffe

Honors and Awards

• Honorary Fellow, Royal College of Physicians of Ireland (2006)
• Fellow, American Gastroenterological Association (2006)
• Fellow, American Society for Gastrointestinal Endoscopy (2006)
• Master, American College of Physicians (2006)
• Biographee, Who's Who in the World (2006)

Professional Education

Graduate & Fellowship Program Affiliations

• Medicine

Industry Relationships

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Research Interests

My primary current clinical research interests are focused on treatment of chronic hepatitis C with nitazoxanide as well as treatment of chronic hepatitis B, application of hepatitis vaccination especially in patients with chronic liver disease, and selection and outcomes of liver transplantation. In the past, I and my colleagues have studied the role of standard interferon, interferon alfacon-1, and peginterferon alone or with ribavirin for the treatment of chronic hepatitis C. We have also documented the role of liver transplantation for fulminant hepatic failure associated with mushroom poisoning, reviewed the institutional results of new liver transplant programs, reported a variant of recurrent hepatitis B after liver transplantation called fibrosing cholestatic hepatitis, documented that the results of liver transplantation in Asian patients with chronic hepatitis B are the same as the transplant outcomes of non-Asians, assessed the quality of life following liver transplantation using a comprehensive profile of psychologic testing, reviewed selection criteria and outcomes of liver transplantation for controversial indications, defined criteria for liver transplantation and associated comorbidities in patients with alcoholic liver disease, proposed minimal listing criteria for liver transplantation, and wrote several textbook chapters on selection of patients for liver transplantation.

I have been a principle investigator in multiple clinical trials using various interferons, combined interferon or peginterferon plus ribavirin, and nitazoxanide for the treatment of chronic hepatitis C, antiviral trials using lamivudine and famciclovir for the treatment of chronic hepatitis B, optimal management of hepatitis B patients after liver transplantation, and trials of hepatitis B and hepatitis A vaccines. I reported that hepatitis A and B is more severe in patients with chronic liver disease, and demonstrated in an international trial the safety and efficacy...

Publications

• Digestive Diseases and Sciences--past, present, and future. Keeffe EB, Dig Dis Sci. 2009; 54 (1): 1-4
• Improved virologic response in chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon, and ribavirin. Rossignol JF, Elfert A, El-Gohary Y, Keeffe EB. Gastroenterology. 2009; 136 (3): 856-62
• Clinical course of hepatitis B virus infection during pregnancy. Nguyen G, Garcia RT, Nguyen N, Trinh H, Keeffe EB, Nguyen MH. Aliment Pharmacol Ther. 2009; 29 (7): 755-64
• Diagnosis and treatment of chronic hepatitis B: 2009 update. Morgan M, Keeffe EB. Minerva Gastroenterol Dietol. 2009; 55 (1): 5-22
• Chronic hepatitis B: early viral suppression and long-term outcomes of therapy with oral nucleos(t)ides. Nguyen MH, Keeffe EB. J Viral Hepat. 2009; 16 (3): 149-55