Emmanuel Mignot

Clinical Focus

• Sleep Disorders
• Narcolepsy Cataplexy Syndrome
• Kleine-Levin Syndrome

Administrative Appointments

• Director, Center For Narcolepsy (1989 - 2015)
• Director, Center For Sleep Sciences and Medicine (2010 - 2015)

Honors and Awards

• Elected member, Institute of Medicine (2006)
• Sleep Research Society, Outstanding Scientific Achievement Award (2006)
• W. Alden Spencer Award, College of Physicians and Surgeons of Columbia University (2004)
• Foster Elting Bennett Memorial Lecture Award, American Neurological Association (2004)
• Investigator Award, Howard Hughes Medical Institute (2002-2010)

Professional Education

Postdoctoral Advisees

Alberto De la Herran Arita,  Brian Grone,  Birgitte Kornum,  Abinav Singh,  Simon Warby,  Guoqiang Yu

Graduate & Fellowship Program Affiliations

• Genetics
• Immunology
• Neurobiology
• Neurology and Neurol Sciences
• Neurosciences
• Psychiatry and Behavioral Science
• Molecular and Genetic Medicine

Community and International Work

• GWAS studies in narcolepsy and KleineLevin 
• immunochip 

Internet Links

• Center For Sleep Sciences and Medicine

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information

Current Research Interests

1) Clinical/outcome studies in various sleep disorders, with use of web based evaluation tools and genetics

2) Human genetic studies in sleep disorders (GWAS, sequencing):
-Narcolepsy
-Kleine Levin syndrome
-Rare familial syndromes with sleep disturbances

3) Immunological and microbiomic studies in human narcolepsy and Kleine Levin syndrome
-Isolation of biomarkers such as autoantibodies, genome wide expression
-Sequencing studies of the TCR repertoire

4) EEG signal processing analysis for automatic scoring and discovery of novel disease bio markers for neuropsychiatric disorders and clinical applications in sleep disorders medicine

Genetic basis of the response to hypoxia and hypercapnia

Clinical Trials

• Measured Hypocretin Levels and Recovery After Hip Surgery Enrolling by Invitation

Publications

• Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons. Appelbaum L, Wang G, Yokogawa T, Skariah GM, Smith SJ, Mourrain P, Mignot E. Neuron. 2010; 68 (1): 87-98
• Post-streptococcal auto-antibodies inhibit protein disulfide isomerase and are associated with insulin resistance. Aran A, Weiner K, Lin L, Finn LA, Greco MA, Peppard P, Young T, Ofran Y, Mignot E. PLoS One. 2010; 5 (9): e12875
• Kleine-Levin syndrome: a systematic study of 108 patients. Arnulf I, Lin L, Gadoth N, File J, Lecendreux M, Franco P, Zeitzer J, Lo B, Faraco JH, Mignot E. Ann Neurol. 2008; 63 (4): 482-93
• Why we sleep: the temporal organization of recovery. Mignot E, PLoS Biol. 2008; 6 (4): e106
• Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. Yokogawa T, Marin W, Faraco J, Pézeron G, Appelbaum L, Zhang J, Rosa F, Mourrain P, Mignot E. PLoS Biol. 2007; 5 (10): e277