Elizabeth Mellins
Academic Appointments
Appointment
Organization
Associate Professor - Med Center Line
Member
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Honors & Awards
Title
Organization
Date(s)
Within Our Reach grant recipient
ACR Research & Education Fund
2007
Distinguished Service Award
American Association of Immunologists
2005
Administrative Appointments
Title
Organization
Start Year
End Year
Advisory Board
Nature, Clinical Practice Rheumatology
2005
-
Developer and co-Director, Introduction to Medicine for PhDs
Stanford School of Medicine
2001
-
Member, Medical and Scientific Advisory Council
Arthritis Foundation (national)
2003
2006
Member,CMB-I StudySection
NIAID, NIH
2002
2007
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
M.D.
Harvard Medical School
Medicine
1978
Research Interests
Our lab focuses on the study of antigen presentation by major histocompatibility complex (MHC) class II molecules. We have been particularly interested in the molecular mechanisms and intracellular steps involved in the generation of complexes between MHC class II molecules and peptides. Our work in this area has elucidated the roles of invariant chain and HLA-DM,
two molecules which regulate peptide-loading of class II molecules. In addition, we have investigated the molecular basis of HLA-DR4 association with rheumatoid arthritis. Ongoing
studies deal with:
1. Analysis of the biosynthesis, structure, and structure/function relationships of the HLA-DM and HLA-DO molecules.
2. Regulation of class II biosynthesis in professional antigen presenting cells.
3. Mechanistic basis of HLA allele association with autoimmune disease
4.Pathogen evasion of the class II pathway.
two molecules which regulate peptide-loading of class II molecules. In addition, we have investigated the molecular basis of HLA-DR4 association with rheumatoid arthritis. Ongoing
studies deal with:
1. Analysis of the biosynthesis, structure, and structure/function relationships of the HLA-DM and HLA-DO molecules.
2. Regulation of class II biosynthesis in professional antigen presenting cells.
3. Mechanistic basis of HLA allele association with autoimmune disease
4.Pathogen evasion of the class II pathway.
Community and International Work
- Childhood Arthritis and Rheumatology Research Alliance More »
Publications
- Hornell TM, Burster T, Jahnsen FL, Pashine A, Ochoa MT, Harding JJ, Macaubas C, Lee AW, Modlin RL, Mellins ED "Human Dendritic Cell Expression of HLA-DO Is Subset Specific and Regulated by Maturation." J Immunol 2006; 176: 6: 3536-47 More »
- Lee AW, Hertel L, Louie RK, Burster T, Lacaille V, Pashine A, Abate DA, Mocarski ES, Mellins ED "Human cytomegalovirus alters localization of MHC class II and dendrite morphology in mature Langerhans cells." J Immunol 2006; 177: 6: 3960-71 More »
- Busch R, Rinderknecht CH, Roh S, Lee AW, Harding JJ, Burster T, Hornell TM, Mellins ED "Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression." Immunol Rev 2005; 207: 242-60 More »
- Mellins ED, Rider LG "Clinical research networks: a step towards evidence-based practice in pediatric rheumatology." Nat Clin Pract Rheumatol 2007; 3: 2: 59 More »
- Rinderknecht CH, Belmares MP, Catanzarite TL, Bankovich AJ, Holmes TH, Garcia KC, Nanda NK, Busch R, Kovats S, Mellins ED "Posttranslational regulation of I-Ed by affinity for CLIP." J Immunol 2007; 179: 9: 5907-15 More »
27 publications: view full list