Elizabeth Mellins
Academic Appointments
- Associate Professor - Med Center Line, Pediatrics - Human Gene Therapy
- Member, Bio-X
Contact Information
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Clinical Offices
Medicine Specialties Clinic 730 Welch Rd 2nd Floor Palo Alto, CA 94304 Tel Work (650) 736-7642 Fax (650) 736-4344Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
Professional Snapshot
Clinical Focus
- Pediatric Rheumatology
- Rheumatology, Pediatric
Administrative Appointments
- Advisory Board, Nature, Clinical Practice Rheumatology (2005 - present)
- Developer and co-Director, Introduction to Medicine for PhDs, Stanford School of Medicine (2001 - present)
- Member, Medical and Scientific Advisory Council, Arthritis Foundation (national) (2003 - 2006)
- Member,CMB-I StudySection, NIAID, NIH (2002 - 2007)
Honors and Awards
- Within Our Reach grant recipient, ACR Research & Education Fund (2007)
- Distinguished Service Award, American Association of Immunologists (2005)
Professional Education
| Board Certification: | General Pediatrics, American Board of Pediatrics (1983) |
| Fellowship: | University of Washington Medical Center, WA USA (1982) |
| Residency: | University of Washington Medical Center, WA USA (1981) |
| Residency: | University of Colorado Health Science Center, CO (1980) |
| Medical Education: | Harvard Medical School, MA (1978) |
Postdoctoral Advisees
Henriette MacMillan, Narendiran Rajasekaran, Nan Wang, Taejin Yoon
Graduate & Fellowship Program Affiliations
Community & International Work
Scientific Focus
Research Interests
Our lab focuses on the study of antigen presentation by major histocompatibility complex (MHC) class II molecules. We have been particularly interested in the molecular mechanisms and intracellular steps involved in the generation of complexes between MHC class II molecules and peptides. Our work in this area has elucidated the roles of invariant chain and HLA-DM,
two molecules which regulate peptide-loading of class II molecules. In addition, we have investigated the molecular basis of HLA-DR4 association with rheumatoid arthritis. Ongoing
studies deal with:
1. Analysis of the biosynthesis, structure, and structure/function relationships of the HLA-DM and HLA-DO molecules.
2. Regulation of class II biosynthesis in professional antigen presenting cells.
3. Mechanistic basis of HLA allele association with autoimmune disease
4.Pathogen evasion of the class II pathway.
Publications
- Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states. Clin Immunol. 2009
- Breaking old paradigms: Th17 cells in autoimmune arthritis. Clin Immunol. 2009; (3): 295-304
- Oligoarticular and polyarticular JIA: epidemiology and pathogenesis. Nat Rev Rheumatol. 2009; (11): 616-26
- Modulation of peripheral B cell tolerance by CD72 in a murine model. Arthritis Rheum. 2008; (10): 3192-204
- Posttranslational regulation of I-Ed by affinity for CLIP. J Immunol. 2007; (9): 5907-15
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