Edgar Engleman
Academic Appointments
- Professor, Pathology
- Member, Stanford Cancer Institute
- Professor, Medicine - Immunology & Rheumatology
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 723-7960
Professional Overview
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
The goal of this laboratory is to better understand dendritic cell biology with the objective of using this information to discover and develop more effective immunotherapeutic approaches to disease. We pursue this goal by performing experiments in both mice and humans. In our initial clinical studies antigen pulsed dendritic cells were administered to patients with cancer or life-threatening viral infections in order to induce specific immunity. The results of these trials have been extremely encouraging. More recently we have focused our studies on the development and life cycle of dendritic cells, including Langerhans cells, and the results have not only shed new light on dendritic cell biology but also have led to our ability to target dendritic cells in vivo without having to manipulate these cells in vitro. We believe that this new approach will eventually make it possible to downregulate as well as upregulate the immune system in an antigen specific manner.
Clinical Trials
- Recruiting Donor Peripheral Stem Cell Transplant in Treating Patients With Hematolymphoid Malignancies
- Not Recruiting Mixed Chimera Allo Transplantation in Multiple Myeloma
- Not Recruiting Phase I/II Intratumoral DC Immunotherapy With Gemcitabine & XRT in Unresectable Pancreatic Cancer
- Not Recruiting Phase I Intratumoral Dendritic Cell Immunotherapy in Thermally Ablated Liver Metastases
- Not Recruiting Talactoferrin in Treating Patients With Relapsed or Refractory Non-Small Cell Lung Cancer or Squamous Cell Head and Neck Cancer
Publications
- Cd14 SNPs regulate the innate immune response. Mol Immunol. 2012; (2): 112-27
- Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants. Am J Transplant. 2012; (5): 1133-45
- B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med. 2011; (5): 610-7
- Plasmacytoid dendritic cell dichotomy: identification of IFN-α producing cells as a phenotypically and functionally distinct subset. J Immunol. 2011; (3): 1477-85
- T(H)1, T(H)2, and T(H)17 cells instruct monocytes to differentiate into specialized dendritic cell subsets. Blood. 2011; (12): 3311-20
- The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP. Blood. 2011; (17): 4569-79
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