Douglas L. Brutlag

Honors and Awards

• Teacher Scholar Award, Henry and Camille Dreyfus (1979)
• Fellow, American Association for the Advancement of Science (1986)
• Best Computer Application in Science, Computerworld-Smithsonian Award (1992)
• Fellow, American College of Medical Informatics (2001)
• Honorary Professor, Keio University (2001)

Professional Education

Graduate & Fellowship Program Affiliations

• Biochemistry
• Biomedical Informatics
• Biophysics

Community and International Work

• Presidential Advisor, Max Planck Institute, Germany 

Internet Links

• Doug Brutlag's Research

Current Research Interests

My primary interest is to understand the flow of information from the genome to the phenotype of an organism. This interest includes predicting the structure and function of molecules from their primary sequence, predicting function from structure and finally simulating protein folding and protein-ligand docking. These goals are the same as the goals of molecular biology, however, we use primarily computational approaches.

Publications

• Dynamic use of multiple parameter sets in sequence alignment. Huang X, Brutlag DL. Nucleic Acids Res. 2007; 35 (2): 678-86
• Using stochastic roadmap simulation to predict experimental quantities in protein folding kinetics: folding rates and phi-values. Chiang TH, Apaydin MS, Brutlag DL, Hsu D, Latombe JC. J Comput Biol. 2007; 14 (5): 578-93
• A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Saxonov S, Berg P, Brutlag DL. Proc Natl Acad Sci U S A. 2006; 103 (5): 1412-7
• A graph-based motif detection algorithm models complex nucleotide dependencies in transcription factor binding sites. Naughton BT, Fratkin E, Batzoglou S, Brutlag DL. Nucleic Acids Res. 2006; 34 (20): 5730-9
• Development and validation of a consistency based multiple structure alignment algorithm. Ebert J, Brutlag D. Bioinformatics. 2006; 22 (9): 1080-7