Dominika Elmlund
Academic Appointments
- Postdoctoral Research fellow, Structural Biology
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Scientific Focus
Current Research Interests
I am interested in the structural biology of TFIID-dependent transcription. My investigations are focused toward determining the roles of TBP-lacking and TBP-containing TFIID states in the dynamic transcription initiation process. I am also involved in development of new computational methods for 3D structure determination from electron microscopic projection images of single-particles. The collection of algorithms developed so far constitutes a new open source software package SIMPLE (Single-particle IMage Processing Linux Engine. SIMPLE is an easy-to-use image processing system for semi-automated ab initio 3D reconstruction from very challenging single-particle data sets, involving asymmetrical and structurally heterogeneous particles. Structures determined so far include the AAA+ assemblies of cobalt and magnesium chelatase, different conformations of the EF-G bound ribosome, different states of RNA polymerase II, as well as TBP-containing and TBP-lacking states of TFIID. Download SIMPLE at: http://simple.stanford.edu
Publications
- Subunit arrangement in the dodecameric chloroplast small heat shock protein Hsp21. Protein Sci. 2011; (2): 291-301
- The activity of barley NADPH-dependent thioredoxin reductase C is independent of the oligomeric state of the protein: tetrameric structure determined by cryo-electron microscopy. Biochemistry. 2011; (18): 3713-23
- ATP-induced conformational dynamics in the AAA+ motor unit of magnesium chelatase. Structure. 2010; (3): 354-65
- Ab initio structure determination from electron microscopic images of single molecules coexisting in different functional states. Structure. 2010; (7): 777-86
- High-resolution single-particle orientation refinement based on spectrally self-adapting common lines. J Struct Biol. 2009; (1): 83-94
- The AAA(+) motor complex of subunits CobS and CobT of cobaltochelatase visualized by single particle electron microscopy. J Struct Biol. 2009; (3): 227-34
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