Daya Upadhyay

Clinical Focus

• Lung Cancer, Solitary Pulmonary Nodule
• Asthma, Adult
• Pulmonology (Lung) and Critical Care
• Pulmonary Medicine

Administrative Appointments

• Assistant Professor of Medicine, Pulmonary and Critical Care, Stanford University (2006 - present)
• Instructor in Medicine/ Staff Physician, Pulmonary and Critical Care, Stanford University (2002 - 2006)
• Attending Staff Physician, Kindred Care Mechanical Ventilator Facility (Vencor), Chicago, IL (2001 - 2002)
• Instructor in Medicine, Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL. (2001 - 2002)
• Chief Resident, Internal Medicine, The New York University Medical Center, NY (1997 - 1998)
View All 7administrative appointments of Daya Upadhyay

Honors and Awards

• 12. Americas' Top Physicians, Consumers’ Research Council of America (2008)
• 11. Faculty Fellow, Stanford University (2008)
• 10. Faculty Teaching Award Nominee, Stanford University (2006)
• 9. Career Investigator Award, National Institute of Health (2005)
• 8. ALA Independent Investigator Award, American Lung Association (2004)

Professional Education

Graduate & Fellowship Program Affiliations

• Cancer Biology
• Medicine
• Pediatrics
• Cell Biology
• Bioengineering

Community & International Work

• Member, Cell Signaling World Congress 
• Member, American Thoracic Society 
• Member, American College of Chest Physicians 
• Member, European Respiratory Society 
• Member, American College of Chest Physicians Women Physician’s network 

Web Site Links

• http://med.stanford.edu/profiles/Daya_Upadhyay/

Research Interests

Dr. Upadhyay examines the mechanisms of ‘Airway Inflammation and Lung Cancer’. Our studies are focused on examining the gene expressions that are involved in ‘accelerated aging of lung’ or senescence which occurs due to smoking, COPD or environmental pollutants that may lead to the development of lung cancer and cancer stem cells. Blood / tissue microRNA and gene expression studies are performed to examine early evidence of cancer and cancer stem cells.

In collaboration with Environmental Air Pollution Agency, we examines the molecular mechanisms of ‘Airway Inflammation induced by Air Pollution’ (ambient air pollution particles 2.5 microns, residual oil fly ash and diesel) in the lung, in health and in inflammatory airway diseases such as asthma, bronchitis, Bronchiectasis, PCD and Cystic Fibrosis. Our specific focus is to analyze exhaled breath condensates and human airway tissues gene expressions that regulate airway inflammation in Asthma in comparison with a complex duo of ‘Asthma and obesity’.

Dr. Upadhyay’s clinical interests are inflammatory airway diseases and lung cancer. She runs Asthma Clinic and a Lung Nodule Clinic at the Stanford University Hospital. Her clinical areas of expertise include airway diseases such as Asthma, Bronchitis, Bronchiectasis, Primary Ciliary Dyskinesia, Cystic Fibrosis and COPD.

Dr. Upadhyay’s research is funded by National Institute of Health (NIH) and American Lung Association Grants.

Clinical Trials

• Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma Recruiting

Publications

• PKC-epsilon mediates air pollution induced cytokine mediated airway epithelial inflammation in human. Cho D-Y,, Le W, Kamdar O, Yee A, Hwang PH, Upadhyay D.. Am J Rhinol. 2009; 9 (9)
• Nicotine induces resistance to chemotherapy in nasal epithelial cancer Shen T, Le W, Yee A, Kamdar O, Hwang PH, Upadhyay D.. Am J Rhinol. 2009; 9 (9)
• Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. Zhang J, Kamdar O, Le W, Rosen GD, Upadhyay D. Am J Respir Cell Mol Biol. 2009; 40 (2): 135-46
• Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium. Kamdar O, Le W, Zhang J, Ghio AJ, Rosen GD, Upadhyay D. FEBS Lett. 2008; 582 (25-26): 3601-6
• Bim mediates mitochondria-regulated particulate matter-induced apoptosis in alveolar epithelial cells. Zhang J, Ghio AJ, Chang W, Kamdar O, Rosen GD, Upadhyay D. FEBS Lett. 2007; 581 (22): 4148-52