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Key Documents

David C. Yeomans

Academic Appointments

Contact Information

  • Academic Offices
    Personal Information
    Email Tel (650) 725-5864
    Administrative Contact
    Ling Zhou Administrative Assistant Tel Work 650.725.7442

Professional Snapshot

Administrative Appointments

  • Vice Chair, Animal Care and Use Committee (2002 - 2005)
  • Executive Committee, Neuroscience Institute at Stanford (2002 - 2005)
  • Director of Pain Research, Anesthesia (2000 - present)
  • Associate Professor, Anesthesia (2000 - present)
  • Assistant Professor of Anatomy and Cell Biology, University of Illinois at Chicago (1996 - 2000)
    • View All 6administrative appointments of David Yeomans

Honors and Awards

  • Pfizer Professor of Pain Medicine, Pfizer Foundation (2002-2003)
  • National Grant Review Committee, Veterans Administration (2005)
  • National Grant Review Committee, NSF IBN - ad hoc (2005)
  • National Grant Review Committee, NIH IRG - ZRG1 IFCN - 7 (2005)

Professional Education

AB: Dartmouth College, Psychology (1979)
PhD: University of Florida, Neuroscience (1989)

Postdoctoral Advisees

Helen Shinn

Graduate & Fellowship Program Affiliations

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities. View Full Information

Consulting: Adynxx, Inc. , Mayer Brown , NeoStim, Inc , Trigemina, Inc.
Equity: Adynxx, Inc. , NeoStim, Inc , Trigemina, Inc.

Scientific Focus

Current Research Interests

My laboratory’s research is centered on achieving a better understanding of and improving the management of pain. This work can be roughly divided into two distinct parts: pain physiology and diagnosis and pain therapy. In terms of pain diagnosis, my laboratory is focused on identifying biomolecular and physiological markers that are indicative of different pain pathologies and can be directive in choosing therapies for that pain state. Thus, we are examining changes in pain nerve (nociceptor) gene expression in skin and nerve tissue. For example, we have recently investigated changes in expression of voltage gated sodium channels under inflammatory and post-incisional conditions. We have also studied the release of neuropeptide, cytokine, and trophic biomarkers into skin and into the spinal epidural space during different pain and inflammatory states in rodents and humans and the effects of treatments on this release. This biomarker methodology is very useful in the process of analgesic and anti-inflammatory therapy development.
Pain Physiology

Pain is primarily subtended by two distinct nociceptor types. When activated, the thinly myelinated A-delta pain fibers create the sensation of sharp, pricking pain, whereas activation of unmyelinated C fibers produces a burning or aching sensation. One or the other type of nociceptor is thought to be dominant in different human pain states. Several years ago, we developed simple methods for differentiating pain or responses evoked by the activation of A-delta or C fiber nociceptors in humans and animals. Using a laser-based stimulation system, we are performing experiments examining both electrophysiological and biochemical responses to these two pain types. Some of this work is done in rodents, wherein we perform both single unit nociceptor recordings, as well as recordings from nociceptive neurons in the spinal cord. We are also using a combination of cortical evoked potential responses to laser pulsed...

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