David Solow-Cordero
Academic Appointments
- Director, HTBC, Chemical and Systems Biology
Key Documents
Contact Information
- Contact Information
Personal Information Email Tel (650) 725-6002
Professional Overview
Current Role at Stanford
Director, High-Throughput Bioscience Center
The High-Throughput Bioscience Center's mission is to provide researchers at Stanford with the ability to run high-throughput chemical, siRNA, cDNA, and high-content screens for the purpose of drug and/or target discovery. The HTBC is a Stanford University School of Medicine core facility and was created in 2003 by the Department of Chemical and Systems Biology (formerly Molecular Pharmacology). The HTBC is a shared resource (Bioscience Screening Facility) for the Stanford Cancer Institute (more info), the Digestive Disease Center (Chemical Genomics Core), and the NIH Clinical and Translational Science Award (Spectrum).
Research approaches that were previously done exclusively in industry are now being used in academia to advance basic research. This high-throughput screening (HTS) laboratory allows Stanford researchers and others to discover novel modulators of targets that otherwise would not be practical in industry. The center incorporates instrumentation (purchased with NCRR NIH Instrumentation grant numbers S10RR019513 and S10RR026338), databases, compound libraries, and personnel whose previous sole domains were in industry. Among our instrumentation are a Molecular Devices ImageXpress Micro High-Content fluorescence microplate imager, with live cell and phase contrast/brightfield options, a Caliper Life Sciences SciClone ALH3000 and an Agilent Bravo microplate liquid handler, and the Molecular Devices Analyst GT and FlexStation II 384 and Tecan Infinite M1000 fluorescence, luminescence and absorbance multimode microplate readers. We have over 130,000 small molecules for compound screens, 15,000 cDNAs for genomic screens, and the siARRAY whole human genome siRNA library from ThermoFisher Scientific (formerly Dharmacon) targeting 21,000 genes.
The HTBC is located in CCSR Room 0133-North Wing, between the Transgenic Mouse Facility, the Immune Monitoring Core, and the Stanford Functional Genomics Facility.
Professional Interests
High-Throughput Screening of small molecule drug libraries and whole genome human and mouse siRNA libraries.
Education and Certifications
| PhD: | University of California, Berkeley, Molecular and Cellular Biology (1995) |
| BS: | MIT, Applied Biology (1990) |
Internet Links
Professional Affiliations and Activities
- Member, Cancer Institute (2008 - present)
Publications
- Design and synthesis of procollagen C-proteinase inhibitors. Bioorg Med Chem Lett. 2012; (24): 7397-401
- Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects. Proc Natl Acad Sci U S A. 2012; (37): E2476-85
- Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 2011; (4): 1311-4
- Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med. 2011; (94): 94ra70
- Molecular imaging of phosphorylation events for drug development. Mol Imaging Biol. 2009 May-Jun; (3): 144-58
- A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell. 2009; (2): 228-39
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