David Feldman
Academic Appointments
Appointment
Organization
Emeritus (Active) Professor
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Curriculum Vitae PDF
Web Site Links
Research/Lab website:
My Lab Site
Research Interests
Steroid hormones act by binding to intracellular receptors which regulate the expression of specific genes in target cells. My group is studying a number of aspects that relate molecular and cellular events of hormone action at the receptor level to clinically relevant questions. Some of the current projects are as follows:
1. Elucidation of the molecular basis of hereditary vitamin D resistant rickets, a genetic disease due to mutations in the vitamin D receptor.
2. Analysis of the endocrinologic mechanisms regulating vitamin D receptor expression and thereby modulating target organ sensitivity to the actions of vitamin D and its analogs.
3. Investigation of the role of vitamin D as a differentiating and antiproliferative agent with the potential to affect malignant cells, specifically prostate cancer.
4. Study of genetic variations in the vitamin D receptor gene and inheritance of low bone mass in relation to the development of osteoporosis.
1. Elucidation of the molecular basis of hereditary vitamin D resistant rickets, a genetic disease due to mutations in the vitamin D receptor.
2. Analysis of the endocrinologic mechanisms regulating vitamin D receptor expression and thereby modulating target organ sensitivity to the actions of vitamin D and its analogs.
3. Investigation of the role of vitamin D as a differentiating and antiproliferative agent with the potential to affect malignant cells, specifically prostate cancer.
4. Study of genetic variations in the vitamin D receptor gene and inheritance of low bone mass in relation to the development of osteoporosis.
Publications
- Swami S, Krishnan AV, Moreno J, Bhattacharyya RB, Peehl DM, Feldman D "Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer." J Nutr 2007; 137: 1: 205S-10S More »
- Krishnan AV, Moreno J, Nonn L, Malloy P, Swami S, Peng L, Peehl DM, Feldman D "Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer." J Steroid Biochem Mol Biol 2007; More »
- Wang J, Malloy PJ, Feldman D "Interactions of the vitamin D receptor with the corepressor hairless: Analysis of hairless mutants in atrichia with papular lesions." J Biol Chem 2007; More »
- Feldman D, Krishnan A, Moreno J, Swami S, Peehl DM, Srinivas S "Vitamin D inhibition of the prostaglandin pathway as therapy for prostate cancer." Nutr Rev 2007; 65: 8 Pt 2: S113-5 More »
- Peng L, Wang J, Malloy PJ, Feldman D "The role of insulin-like growth factor binding protein-3 in the growth inhibitory actions of androgens in LNCaP human prostate cancer cells." Int J Cancer 2007; More »
102 publications: view full list