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Daniel HerschlagAcademic Appointments
Appointment
Organization
Professor
Professor (By courtesy)
Chemical Engineering
Professor (By courtesy)
Chemistry
Member
Member
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Honors & Awards
Title
Organization
Date(s)
Fellow
AAAS
2005
Merit Award
NIH
2002
Cope Scholar Award
ACS
2000
Established Investigator
AHA
1998-2002
Pfizer Award for Enzyme Chemistry
ACS
1997
14 honors and awards: view full list
Postdoctoral Advisees
Marcello Forconi,
Jonathan Lassila,
Eliza Ruben,
Jason Schwans,
Xue Song Shi,
Sergey Solomatin
Web Site Links
Research/Lab website:
Herschlag Group Home Page
Research Interests
Our research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes. Comparing and contrasting the behavior of RNA and protein systems highlights the unique features of these biological macromolecules and helps elucidate principles of folding and catalysis that may be fundamental to both class of functional macromolecules. Toward these ends, many biochemical and biophysical techniques are employed, both within the lab and through multiple collaborations. Finally, we are also involved in collaborative work with Pat Brown's lab aimed at unraveling the global logic and organization of RNA processing and organization. More detailed descriptions are available from our lab home page.
Publications
- Mueller-Planitz F, Herschlag D "Coupling between ATP binding and DNA cleavage by DNA topoisomerase II: A unifying kinetic and structural mechanism." J Biol Chem 2008; More »
- Das R, Kudaravalli M, Jonikas M, Laederach A, Fong R, Schwans JP, Baker D, Piccirilli JA, Altman RB, Herschlag D "Structural inference of native and partially folded RNA by high-throughput contact mapping." Proc Natl Acad Sci U S A 2008; 105: 11: 4144-9 More »
- Lee TH, Lapidus LJ, Zhao W, Travers KJ, Herschlag D, Chu S "Measuring the Folding Transition Time of Single RNA Molecules." Biophys J 2007; More »
- Karbstein K, Lee J, Herschlag D "Probing the Role of a Secondary Structure Element at the 5'- and 3'-Splice Sites in Group I Intron Self-Splicing: The Tetrahymena L-16 ScaI Ribozyme Reveals a New Role of the G.U Pair in Self-Splicing." Biochemistry 2007; More »
- Mueller-Planitz F, Herschlag D "DNA topoisomerase II selects DNA cleavage sites based on reactivity rather than binding affinity." Nucleic Acids Res 2007; More »
90 publications: view full list
