Key Documents
Daniel Bernstein
Academic Appointments
- Professor, Pediatrics - Cardiology
- Member, Cancer Center
Contact Information
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Clinical Offices
Pediatric Heart Center 725 Welch Rd MC 5912 Palo Alto, CA 94304-1601 Tel Work (650) 721-2121 Fax (650) 725-8343Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information Email Tel (650) 723-7913Administrative Contact Kari Costa Administrative Assistant EmailNot for medical emergencies or patient use
Professional Snapshot
Clinical Focus
- Pediatric Cardiology
- Pediatric Heart Transplantation
- Pediatric Heart Failure
Administrative Appointments
- Director, Children's Heart Center, Packard Children's Hospital at Stanford (2001 - present)
Honors and Awards
- Alfred Woodley Salter and Mabel G. Salter Endowed Professor of Pediatrics, Stanford University (April 2004-present)
Professional Education
| Board Certification: | Pediatric Cardiology, American Board of Pediatrics (1985) |
| Fellowship: | UCSF Medical Center, CA (1986) |
| Board Certification: | Pediatrics, American Board of Pediatrics (1984) |
| Fellowship: | Albert Einstein College of Medicine, NY (1983) |
| Residency: | Montefiore Medical Center, NY (1982) |
Postdoctoral Advisees
Web Site Links
Scientific Focus
Current Research Interests
We are interested in the role of the sympathetic nervous system and its cellular components (adrenergic receptors, G proteins) in regulating cardiac development and function. We are also interested in developing tools for examination of cardiovascular physiologic parameters in transgenic and targeted gene disruption mouse models of cardiovascular disease. Specific projects underway in our lab include:
1. Evaluation of the role of beta1 and beta2 adrenergic receptor subtypes in regulating cardiac structure and function by producing mice with targeted gene disruption of these receptors.
2. Evaluation of the role of crosstalk between beta receptors and other signaling pathways (MAPK,Akt,PKC) in regulating cardiac structure and function.
3. Role of beta receptors in regulation of intracellular and intramitochondrial calcium.
4. Role of beta receptors in adriamycin cardiotoxicity.
5. Exercise physiology in the mouse
6. Gene microarray analysis of cardiomyopathy models.
We also are interested in clinical cardiac transplantation in children, specifically:
1. The application of gene microarray methods of cardiac allograft rejection in pediatric patients.
2. Assessment of new techniques of immunosuppression in children.
3. Long-term complications in pediatric heart transplant patients.
Clinical Trials
- B-Receptor Signaling in Cardiomyopathy Recruiting
Publications
- Hypercholesterolemia impairs exercise capacity in mice. Vasc Med. 2009; (3): 249-57
- Endogenous regulation of cardiovascular function by apelin-APJ. Am J Physiol Heart Circ Physiol. 2009; (5): H1904-13
- Genotypic variation and phenotypic characterization of granzyme B gene polymorphisms. Transplantation. 2009; (12): 1801-6
- Association of left ventricular dilation at listing for heart transplant with postlisting and early posttransplant mortality in children with dilated cardiomyopathy. Circ Heart Fail. 2009; (6): 591-8
- Genetic polymorphisms impact the risk of acute rejection in pediatric heart transplantation: a multi-institutional study. Transplantation. 2008; (11): 1632-9
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