Ching-Pin Chang
Academic Appointments
- Assistant Professor, Medicine - Cardiovascular Medicine
- Member, Bio-X
Contact Information
- Academic
Offices
Personal Information Email Tel (650) 736-4108 Tel (650) 736-8539
Professional Snapshot
Honors and Awards
- New Faculty Award, California Institute of Regenerative Medicine (2008-2013)
- March of Dimes Research Program Award, March of Dimes Foundation (2007-2010)
- Medical Grant Award, Children's Heart Foundation (2007)
- Faculty Scholar Award, Donald E. and Delia B. Baxter Foundation (2006)
- National Scientist Development Award, American Heart Association (2005)
Professional Education
| Physician-Scientist Fellowship: | Howard Hughes Medical Institute, Cardiovascular Development (2004) |
| Cardiology Fellowship: | Stanford University Medical Center, Clinical Cardiology (2001) |
| Residency: | Massachusetts General Hospital, Harvard, Internal Medicine (1999) |
| Ph.D.: | Stanford University, Cancer Biology (1997) |
| M.D.: | National Taiwan University, Medicine |
Postdoctoral Advisees
Pei Han , Wei Li , Chien-Jung Lin , Ching Shang , Yiqin Xiong , Jin Yang
Graduate & Fellowship Program Affiliations
Web Site Links
Scientific Focus
Research Interests
My laboratory studies the mechanisms of cardiovascular development, particularly how the three major types of cardiac cells (endocardial, myocardial and epicardial cells) and neural crest cells interact with each other to generate heart tissues. We are interested in the transcriptional and signaling events that coordinate their interactions and assembly into heart tissues. The long-term goal is to understand the developmental mechanisms that control tissue formation and recapitulate the developmental processes for therapeutic or regenerative purposes. Furthermore, we have generated mouse models of cardiomyopathy and models that allow us to study the repair mechanisms of vascular injury in adult. We aim to applying lessons learned from our developmental studies to investigating the mechanisms of adult disease.
Publications
- Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell. 2008; (2): 298-311
- NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006; (7093): 595-600
- A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell. 2004; (5): 649-63
- Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation. Cell. 1999; (4): 587-97
- Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol Cell Biol. 1997; (10): 5679-87
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