Ching-Pin Chang

Clinical Focus

• Cardiovascular Disease

Honors and Awards

• Established Investigator Award, American Heart Association (2012-2016)
• New Faculty Award, California Institute of Regenerative Medicine (2008-2013)
• March of Dimes Research Program Award, March of Dimes Foundation (2007-2010)
• Medical Grant Award, Children's Heart Foundation (2007)
• Faculty Scholar Award, Donald E. and Delia B. Baxter Foundation (2006)

Professional Education

Postdoctoral Advisees

Chen Hao Chen,  Pei Han,  Wei Li,  Chiou-Hong Lin,  Jin Yang

Graduate & Fellowship Program Affiliations

• Cancer Biology
• Medicine
• Cardiovascular Medicine

Internet Links

• My Lab Site

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information

Current Research Interests

The ultimate goal of my laboratory is to define the molecular mechanisms underlying cardiovascular development and disease and translate the bench findings to clinical applications. One objective is to understand how the major types of cardiac cells (endocardial, myocardial, epicardial and neural crest cells) interact with each other to generate heart tissues. We are interested in chromatin regulation, transcriptional and signaling events that coordinate their interactions and assembly into heart tissues. We also study vascular regeneration and repair after injury with emphasis on vascular stem cell biology. The goal is to understand the developmental mechanisms that control tissue formation and repair in order to recapitulate the developmental processes for therapeutic or regenerative purposes. Another objective is to apply lessons learned from developmental studies to investigating the mechanisms underlying adult cardiovascular diseases. We are interested in determining the mechanistic links between cardiac development and adult cardiomyopathy. Furthermore, as part of the effort to understand tissue repair mechanisms following injury, we are investigating the biology of adult stem cells in various tissues that include hair follicles and blood vessels under different pathophysiological conditions. Our goal is to integrate developmental biology, adult pathophysiology, and regenerative medicine toward the understanding and treatment of human diseases.

Publications

• Chromatin regulation by Brg1 underlies heart muscle development and disease. Hang CT, Yang J, Han P, Cheng HL, Shang C, Ashley E, Zhou B, Chang CP. Nature. 2010; 466 (7302): 62-7
• Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C, Bayle JH, Shou W, Iruela-Arispe ML, Chang CP. Dev Cell. 2008; 14 (2): 298-311
• NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR. Nature. 2006; 441 (7093): 595-600
• A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Chang CP, Neilson JR, Bayle JH, Gestwicki JE, Kuo A, Stankunas K, Graef IA, Crabtree GR. Cell. 2004; 118 (5): 649-63
• Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation. Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C. Cell. 1999; 96 (4): 587-97