Benign prostatic hyperplasia
Benign prostatic hyperplasia (BPH) is the enlargement of the prostate gland leading to urinary symptoms in many older men. BPH pathogenesis is poorly understood, and current treatments are only partially effective. By transcriptional profiling of bulk tissue and single cells, we recently identified novel signaling molecules linked to BPH pathogenesis (e.g., BMP5 and CXCL13), and discovered a fundamental “re-landscaping” of cell types in BPH. Current efforts seek to further define the cells and molecules driving BPH, and leverage that knowledge towards new disease-focused therapies.