Pollack Lab: Translational Cancer Genomics
LOCATION: Center for Clinical Sciences Research (CCSR-3240/50)
OTHER AFFILIATIONS: Cancer Biology Program, Bio-X Program
Research areas span an eclectic mix of projects, focused around translational cancer genomics. Studies cover several tumor types, including prostate, breast and pancreatic cancer. Technologies include next-generation sequencing (exomes, genomes, transcriptomes, and cistromes), CRISPR/Cas9 genome editing, and single-cell analysis. Rather than study model organisms, we work directly with human tissue specimens and patient-derived cell culture models.
Active areas of investigation include:
- Defining prostate tumor heterogeneity and genome evolution to distinguish indolent from aggressive disease.
- Identifying recurring structural genome alterations in varied cancer types to discover novel cancer genes.
- Understanding the role of altered chromatin remodelers and "lineage-survival" transcription factors in tumorigenesis.
- Investigating mechanisms underlying genomic instability and the shaping of cancer genomes.
- Applying genomic appoaches to study less common neoplasms, and benign proliferative diseases.
- Exploring cellular heterogeneity through single-cell analysis in human health and disease.