Pollack Lab Vitals:

DEPARTMENT: Pathology

LOCATION: Center for Clinical Sciences Research (CCSR-3240)

OTHER AFFILIATIONS: Cancer Biology Program, Bio-X Program

Research Synopsis:

The Pollack lab uses genomic approaches to investigate the pathobiology of human cancer, and to identify strategies for improved diagnosis, prognostication and treatment. Technologies include deep sequencing (exomes, genomes, transcriptomes, and cistromes), DNA microarrays, RNAi screens, genome editing, and single-cell analysis. Studies span several tumor types, including prostate, breast, lung, colon and pancreatic cancer. Rather than study model organisms, we work directly with human cancer specimens and patient-derived cells.

Active areas of investigation include:

  • Defining prostate tumor heterogeneity and genome evolution to distinguish indolent from aggressive disease.
  • Identifying recurring structural genome alterations in varied cancer types to discover novel cancer genes.
  • Understanding the role of altered chromatin remodelers and "lineage-survival" transcription factors in tumorigenesis.
  • Investigating mechanisms underlying genomic instability and the shaping of cancer genomes.
  • Applying genomic methods to study less common neoplasms and benign diseases.
  • Exploring cellular heterogeneity through single-cell analysis in human health and disease.