PHS maintains diverse collaborations around to world to spur interdisciplinary population health research.
Aarhus University and the Danish Registers
Denmark has hundreds of linkable population-based registries and databases available for research. These include administrative, health, and clinical quality databases linkable using civil registration numbers, part of the Danish Civil Registration System established in 1968. Taken together these represent nearly complete population coverage and follow-up, universal healthcare access, and deterministic linkage. An understanding of the state, regional and municipal-levels of the healthcare system is critical to successful research using these data, but the opportunities for working with a dynamic cohort with long-term follow-up are extensive across disciplines.
To date, the Stanford-Aarhus partnership has resulted in deep investigations of dementia, stress disorders and mental health, healthcare utilization and cost blooms, neighborhood level indicators of later outcomes, among others. Several cohorts have been identified as priorities for future research collaboration, including the Danish Labor Force Survey (LFS), the aging population, and pediatric data.
In collaboration with PHS, researchers develop research proposals, and if aligned with the research agenda, work closely with an Aarhus data scientist who manages the data and supports analysis throughout the research process.
Born in Bradford
Born in Bradford is a prospective pregnancy and birth cohort established to examine how genetic, nutritional, environmental, behavioral and social factors affect health and development during childhood, and subsequently adult life, in a deprived multi-ethnic population. It was developed in close consultation with local communities, clinicians and policy makers with commitment from the outset to undertake research that would both inform interventions to improve health in the city and generate robust science relevant to similar communities in the UK and across the world. Between 2007 and 2011 information on a wide range of characteristics were collected from 12,453 women (and 3,356 partners) who experienced 13,778 pregnancies and delivered 13,818 live births.
The Stanford Federal Statistical Research Data Center (FSRDC) allows qualified researchers to securely use restricted-access data from the U.S. Census Bureau, the National Center for Health Statistics (NCHS), the Agency for Healthcare Research and Quality (AHRQ), and the Bureau of Labor Statistics. For example, researchers can access detailed geographic indicators that are not publicly available in data such as the National Health Interview Survey (NHIS) and National Health and Nutrition Examination Survey (NHANES).
If you wish to use FSRDC data for a health related project, please contact the PHS Data Core.
Research Centre for Toxic Compounds in the Environment (RECETOX)
Research Centre for Toxic Compounds in the Environment Centre is an independent department at Faculty of Science, Masaryk University, with its own research and development, educational programmes and expert activities within the field of environmental contamination. Centre focuses on persistent organic pollutants (POPs), polar organic compounds, toxic metals and their species and natural toxins - cyanotoxins.
Scientific activities of the Centre are carried out in twelve working groups collaborating within the framework of four research programmes:
- Environmental chemistry and modeling
- Organic photochemistry and supramolecular chemistry
- Protein engineering
American Manufacturing Cohort
AMC data is a rich source of occupational exposure, health, medical claims, human resources, payroll and workplace safety information spanning from 1996 to 2013 for a cohort of 230,000 manufacturing workers employed at the multinational aluminum manufacturing company, and their spouses/dependents. Linkages to other national datasets--including Census, CMS, death data and health risk score data--allow researchers to investigate cradle-to-grave life course questions such as the role of early life, job exposures, company wellness and insurance policies, and more on health and economic outcomes.
The AMC study data are the product of an academic-corporate partnership forged in 1997 with Dr. Mark Cullen, then Director of Occupational and Environmental Medicine at the Yale University School of Medicine. The partner company worked with Dr. Cullen to incorporate research findings into company policy to improve worker safety. To date, the research agenda has expanded and over 90 manuscripts have been published in the areas of occupational health, corporate benefits structures, time-dependent and cumulative exposure and later life mental and physical health, disability and retirement trajectories and relationship between work and broader societal economic environments. Visit the AMC Consortium website for more information about the data and data access.
Clalit Research Institute
Clalit, the largest healthcare payer/provider system in Israel, is a well-integrated system that owns and operates 14 hospitals and over 1,500 clinics, as well as a nation-wide network of pharmacies, imaging centers, labs and even complimentary medicine clinics. Because members very infrequently switch among health plans (50% of the Israel population), Inpatient, outpatient, pharmacy data, laboratory data, and imaging data, all available for over 15 years.
The Clalit data warehouse contains variables relating to demographics (i.e. age, sex, linkage to mother/father for family mapping analyses, place of birth), health history, hospital admission data, outpatient clinic data, laboratory values, pharmacy data (prescribing and dispensing data), cost (pricelist and real-life monthly cost per patient), and other administrative data. Diagnostic data are primarily based on the International Classification of Diseases, 9th revision (ICD-9) and their associated free text. Additional unstructured data include text, imaging and pathology studies is available.
These data are augmented by the largest ongoing patient experience survey in Israel, which is collected through the Clalit patient portal and Personal Health Record (PHR).
INDEPTH is a research network of 53 health and demography surveillance sites in 24 low- and middle-income countries in Africa and Asia. The network maintains ongoing surveillance of large population blocks, ranging from 10,000 to 300,000 people, each of whom are visited at least once a year, a total of 4.5 million people under direct observation for 10 to 40 years. PHS researchers will be partnering with INDEPTH through local universities on a range of projects, from studying the determinants of changes in the microbiome as they relate to health patterns, with a focus on the role of these environmental changes to cancer risks.
Avon Longitudinal Study of Parents and Children (ALSPAC)
Based at the University of Bristol, the Avon Longitudinal Study of Parents and Children (ALSPAC), also known as Children of the 90s, is a world-leading birth cohort study.
Between April 1991 and December 1992 we recruited more than 14,000 pregnant women into the study and these women (some of whom had two pregnancies or multiple births during the recruitment period), the children arising from the pregnancy, and their partners have been followed up intensively over two decades.
We are the most detailed study of its kind in the world and we provide the international research community with a rich resource for the study of the environmental and genetic factors that affect a person’s health and development. Through our research we aim to inform policy and practices that will provide a better life for future generations.
Danish National Biobank
The Danish National Biobank (DNB) is a physical biobank containing more than 10 million biosamples across an array of diagnostic categories, the Danish Biobank Register that links over 25 million biosamples in Danish biobanks to vast amounts of register information; and the Coordinating Centre that secures smooth sample access. Together they constitute the DNB initiative, and represent unique possibilities in human life science research.
The DNB provides an unbiased sampling of the Danish population such as the PKU blood samples from all newborns since 1982 and samples from more than 800,000 potential controls. Uniquely, sample groups link to vast amounts donor information in the Danish registers - e.g. medical history, school performance, place of living etc. Highly automated management of the DNB result in speed, very low error rate and complete logging of biobank infomation.
Abdul Latif Jameel Poverty Action lab (J-PAL)
The Abdul Latif Jameel Poverty Action Lab (J-PAL) is a global research center working to reduce poverty by ensuring that policy is informed by scientific evidence. Anchored by a network of 171 affiliated professors at universities around the world, J-PAL conducts randomized impact evaluations to answer critical questions in the fight against poverty.
Solano County Public Health Department
BRIDGES (The Bay Area Research Innovation and Discovery: Governance Evaluation and Sustainability) is a collaboration between county public health departments and their constituents, community clinics and health systems, and academic researchers with the goal of developing infrastructure and processes for scalable health information exchanges (HIEs) and to use these HIEs to address research questions of public health importance. HIEs integrate the electronic medical records from county residents and enhance their interoperability, with visions of incorporating additional individual-level data via surveys and other mechanisms for capturing the social determinants of health. BRIDGES aims to integrate health care information electronically across organizations linked with other rich information in order to create an a data ecosystem to provide actionable information that will improve individual and population health.