Individual Seed Projects
Elucidating the mechanisms of Metabolic Cardiomyopathy through Personalized Exosome Profiling, the ExoHeart Collaborative Initiative
An in-house developed high efficient, exosome isolation tool (ExoTiC) will be utilized for exosome and inflammasome isolation from well phenotyped and already bio-banked cohorts available at Stanford University. Exosomal miRNA and inflammasomal protein expression profiles will then be defined.
We will create a blueprint map of exosomal miRNA and inflammasomal protein expression library; for insulin sensitive and resistant individuals before and after exercise (Aim-1), and for insulin sensitive and resistant (non diabetic) vs. diabetic individuals at resting (Aim-2).