Individual Seed Projects

Elucidating the mechanisms of Metabolic Cardiomyopathy through Personalized Exosome Profiling, the ExoHeart Collaborative Initiative

Professor of Radiology (Canary Cancer Center) and, by courtesy, of Electrical Engineering
Task Force member, WHO Pulmonary Hypertension Committee (2013 - 2018)
Scientific Director of Precision Genomics and Pharmacogenomics in Primary Care, Stanford Division of Primary Care and Population Health (2017 - Present)
Chair, Dept. of Genetics (2009 - Present)
(650) 723-4668
Director, Stanford Cardiovascular Institute (2013 - Present)
(650) 736-2246
Director, Human Immune Monitoring Center (2009 - Present)
(650) 723-1671

An in-house developed high efficient, exosome isolation tool (ExoTiC) will be utilized for exosome and inflammasome isolation from well phenotyped and already bio-banked cohorts available at Stanford University. Exosomal miRNA and inflammasomal protein expression profiles will then be defined.

We will create a blueprint map of exosomal miRNA and inflammasomal protein expression library; for insulin sensitive and resistant individuals before and after exercise (Aim-1), and for insulin sensitive and resistant (non diabetic) vs. diabetic individuals at resting (Aim-2).