2018 Individual Seed Projects
Determination of Sepsis Marker Levels in Pregnant Women During the Peripartum Period
- Women are vulnerable to infection in the peripartum period. Outside of pregnancy, markers such as lactate and procalcitonin are used to guide sepsis diagnosis and assess response to treatment. Normal levels of sepsis biomarkers in the peripartum period have not yet been determined. By establishing normal and elevated levels of sepsis markers in the peripartum period, the ability to rapidly diagnose severe maternal infections may greatly improve.
- Compare lactate and procalcitonin levels of infected to non-infected women in the peripartum period.
- Establish preliminary data for normal levels of lactate and procalcitonin in pregnant women in the peripartum period.
- Compare sepsis marker levels between 30 women with intraamniotic infection to 30 women without infection at 3 time points: the start of labor, immediately following delivery and 1 day postpartum.