2018 Individual Seed Projects

Determination of Sepsis Marker Levels in Pregnant Women During the Peripartum Period

Clinical Associate Professor, Obstetrics & Gynecology - Maternal Fetal Medicine

Samantha Do, MD

Fellow, Medicine
Clinical Professor, Obstetrics & Gynecology - Maternal Fetal Medicine
Clinical Assistant Professor, Medicine - Infectious Diseases

Background

  • Women are vulnerable to infection in the peripartum period. Outside of pregnancy, markers such as lactate and procalcitonin are used to guide sepsis diagnosis and assess response to treatment. Normal levels of sepsis biomarkers in the peripartum period have not yet been determined. By establishing normal and elevated levels of sepsis markers in the peripartum period, the ability to rapidly diagnose severe maternal infections may greatly improve.

Objectives

  1. Compare lactate and procalcitonin levels of infected to non-infected women in the peripartum period.
  2. Establish preliminary data for normal levels of lactate and procalcitonin in pregnant women in the peripartum period.

Study design

  • Compare sepsis marker levels between 30 women with intraamniotic infection to 30 women without infection at 3 time points: the start of labor, immediately following delivery and 1 day postpartum.