2017 Individual Seed Projects
Utilizing the Immune Profile of Blood as a Biomarker for Transient Ischemic Attacks
Assistant Professor of Anesthesiology, Perioperative and Pain Medicine (Adult-MSD) and, by courtesy, of Pediatrics (Neonatology) at the Stanford University Medical Center
Born in France, Dr. Gaudilliere studied Engineering at Ecole Polytechnique before completing an MD-PhD degree from the Harvard-MIT Health Sciences and Technology program. During his postdoctoral fellowship in Dr. Garry Nolan’s laboratory (Stanford University), Dr. Gaudilliere developed and standardized a pipeline to implement high dimensional mass cytometry (a.k.a flow cytometry by time of flight mass spectrometry, or CyTOF) in clinical studies. Dr. Gaudilliere's research group combines high parameter mass cytometry with other proteomics approaches and advanced bio-computational methods to study how the human immune system responds and adapts to physiological or pathological stressors. Ongoing studies in the Gaudilliere lab focus on several clinical scenarios including, 1) surgical recovery and traumatic injury, 2) pregnancy and preterm birth (in collaboration with the Bill and Melinda Gates and the March of Dimes foundation, 3) neurocognitive recovery after stroke. Dr. Gaudilliere is also a Board-Certified Anesthesiologist and works clinically in the operating room 25% of his time.
- 300,000 people in the United States experience a TIA annually with over 10% suffering an ischemic stroke in the subsequent 90 days.
- No effective biomarker currently exists.
- Our approach identifies the immune profile of TIAs utilizing state of the art immune monitoring - Mass Cytometry by Time Of Flight Mass Spectrometry (CyTOF)
- Identification of these blood biomarkers will drastically change the current management of TIAs to prevent future strokes