2017 Individual Seed Projects

Elucidating the mechanisms of Metabolic Cardiomyopathy through Personalized Exosome Profiling, the ExoHeart Collaborative Initiative

Professor of Radiology (Canary Cancer Center)
Clinical Associate Professor, Medicine - Cardiovascular Medicine
Professor of Medicine (Primary Care and Population Health) and, by courtesy, of Health Research and Policy (Epidemiology) at the Stanford University Medical Center
Stanford W. Ascherman, MD, FACS, Professor in Genetics
Director, Stanford Cardiovascular Institute, Simon H. Stertzer, MD, Professor and Professor of Radiology
Professor (Research) of Microbiology and Immunology

An in-house developed high efficient, exosome isolation tool (ExoTiC) will be utilized for exosome and inflammasome isolation from well phenotyped and already bio-banked cohorts available at Stanford University. Exosomal miRNA and inflammasomal protein expression profiles will then be defined.

We will create a blueprint map of exosomal miRNA and inflammasomal protein expression library; for insulin sensitive and resistant individuals before and after exercise (Aim-1), and for insulin sensitive and resistant (non diabetic) vs. diabetic individuals at resting (Aim-2).