Peltz Lab In the Department of Anesthesia

Peltz Lab Publications


108 papers as of 2/25/2015



MH Elkomy, P Sultan, B Carvalho, G Peltz, M Wu, C Clavijo, and JL Galinkin, DR Drover. Ondansetron Pharmacokinetics in Pregnant Women and Neonates: Towards a New Treatment for Neonatal Abstinence Syndrome. Clinical Pharmacology & Therapeutics (2015), 97(2): 167-176. PMID: 25670522

D Xu*, M Wu*, S Nishimura, T Nishimura, SA Michie, M Zheng, Z Yang, AJ Yates, JS Day, KM. Hillgren, ST Takeda, Y Guan, Y Guo, and G Peltz. Chimeric TK-NOG Mice: A Predictive Model for Cholestatic Human Liver Toxicity. Journal of Pharmacology and Experimental Therapeutics (2015), 252(2): 274-80. (*Co-First Authors). PMID: 25424997

M Zheng*, H Zhang*, DL. Dill, J. D Clark, S Tu, AL. Yablonovitch, MHow Tan, R Zhang, D Rujescu, M Wu, L Tessarollo, W Vieira, MM Gottesman, S Deng, LS. Eberlin, RN Zare, JM Billard, JP Gillet, JB Li, G Peltz. The Role of Abcb5 Alleles in Susceptibility to Haloperidol-Induced Toxicity in Mice and Humans. PLoS Medicine (2015), 12(2): 1-29. (*Co-First Authors). PMID: 25647612

As of February 25, 2015: This paper had over 12793 views since it was published on 2-2-2015.



Xu D, Nishimura T, Nishimura S, Zhang H, Zheng M, Guo YY, Masek M, Michie SA, Glenn J, Peltz G. Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing. PLoS Medicine (2014), 11(4): 1-9. PMID: 24736310

*This paper was selected as one of the most influential and impactful papers of the past decade by PLoS editors.

Xu D, Nishimura T, Zheng M, Wu M, Su H, Sato N, Lee G, Michie S, Glenn J, and Peltz G. Enabling Autologous Human Liver Regeneration with Differentiated Adipocyte Stem Cells. Cell Transplantation (2014), 23(12): 1573-84. PMID: 24148223

Liang DY, Zheng M, Sun Y, Sahbaie P, Low SA, Peltz G, Scherrer G, Flores C, Clark JD. The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration. BMC Genomics (2014), 15: 345. PMID: 24884839



Nishimura T, Y. Hu, M. Wu, E. Pham, H. Suemizu, M. Elazar, M. Liu, R. Idilman, C. Yurdaydin, P. Angus,  C. Stedman, B. Murphy, J. Glenn, M. Nakamura, T. Nomura, Y. Chen, M. Zheng, W.L. Fitch, and G Peltz. Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction. Journal of Pharmacology and Experimental Therapeutics(2013), 344: 388-98. PMID: 23143674

Y. Hu, M. Wu, T. Nishimura, M. Zheng, G. Peltz. Human pharmacognetic analysis in chimeric mice with “humanized livers”. Pharmacogenetic and Genomics (2013), 23(2): 78-83. PMID: 23241944

Park W, Wu M, Bowen R, Zheng M, Fitch WL, Pai RK, Wodziak D, Bisser B, Poultsides GA, Norton J, Banerjee S, Chen AM, Freidland S, Scott B, Pasricha PJ, Lowe AW, Peltz G.  Metabolomic-derived novel cyst fluid biomarkers for pancreatic cysts: glucose and kynurenine. Gastrointestinal Endoscopy (2013), 78(2): 295-302. PMID: 23566642

M Wu*, Y Xu*, WL Fitch, M Zheng, RE Merritt, JB. Shrager, W Zhang, DL Dill, G Peltz & CD Hoang. Liquid chromatography/mass spectrometry methods for measuring dipeptide abundance in non-small-cell lung cancer. Rapid Communications in Mass Spectrometry (2013), 27(18): 2091-8. (*Co-First Authors). PMID: 23943330

Gallagher JJ, Tajerian M, Guo T, Shi X, Li W, Zheng M, Peltz G, Kingery WS, Clark JD. Acute and chronic phases of complex regional pain syndrome in mice are accompanied by distinct transcriptional changes in the spinal cord. Molecular Pain (2013), 9: 40. PMID: 23924076

Peltz G. Reply to Bissig and Grompe. Trends in Pharmacological Science (2013), 34(8): 426. PMID: 23849814

Peltz G. Can 'humanized' mice improve drug development in the 21st century? Trends in Pharmacological Science (2013), 34(5): 255-60. PMID: 23602782



M. Wu, P. Sahbaie, M. Zheng, R. Lobato, D. Boison, J. D. Clark, and G. Peltz. Opiate-induced Changes in Brain Adenosine Levels and Narcotic Drug Responses. Neuroscience (2012), 228: 235-42. PMID: 23098802

M. Wu, M. Zheng, W. Zhang, S. Suresh, U. Schlecht, W.L. Fitch, S. Aronova, S. Baumann, R. Davis, R. St.Onge, D.L. Dill, G. Peltz. Identification of Drug Targets by Chemogenomic and Metabolomic Profiling in Yeast. Pharmacogenetics and Genomics (2012), 22: 877-86. PMID: 23076370 T.

Zheng M, Dill D, Clark JD, Peltz G. Computational genetic discoveries that could improve perioperative medicine. Current Opinion in Anaesthesiology (2012), 25(4): 428-33. Review. PMID: 22647490

Liu HH, Hu Y, Zheng M, Suhoski MM, Engleman EG, Dill DL, Hudnall M, Wang J, Spolski R, Leonard WJ, Peltz G. Cd14 SNPs regulate the innate immune response. Molecular Immunology (2012), 51(2): 112-27. PMID: 22445606

M. Zheng, M, Dill D., Peltz, G. A Better Prognosis for Genetic Association Studies in Mice. Trends in Genetics (2012), 28 (2): 62-69. PMID: 22118772

Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, Costigan M, Herbert TA, Yarkoni-Abitbul M, Tichauer D, Livneh J, Gershon E, Zheng M, Tan K, John SL, Slade GD, Jordan J, Woolf CJ, Peltz G, Maixner W, Diatchenko L, Seltzer Z, Salter MW, Mogil JS. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nature Medicine (2012), 18(4): 595-9. PMID: 22447075



M. Zheng, G. Peltz.  Genetic discovery: The prescription for chronic pain. Genomic Medicine (2010), 2: 82-84. PMID: 21092146

G. Peltz. Immunomodulation in perioperative medicine. Pain Management (2011), 1(2): 103-106. PMID: 24646349

Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M, Ito M, Suematsu M, Peltz G, Nakamura M, Suemizu H. The reconstituted 'humanized Liver' in TK-NOG mice is mature and functional. Biochemical Biophysical Research Communications (2011), 405(3): 405-410. PMID: 21238430

A.C.M. Boon, D. Finkelstein, G. Liao, M. Zheng, J. Allard, K. Klump, R. Webster, G. Peltz, R.J. Webby. H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load. mBio (2011) 2(5). pii: e00171-11. PMID: 21896679

Peltz G, Zaas AK, Zheng M, Solis NV, Zhang MX, Liu H-H, Hu Y, Boxx GM, Phan QT, Dill D, and S. Filler. Next-Generation Computational Genetic Analysis: Multiple Complement Alleles Control Survival after Candida Albicans. Infection and Immunity (2011), 79: 4472-79. PMID: 21875959

Zhang, X., Liu, H.H., Weller, P., Zheng, M., Wang, J., Liao, G., Monshouwer, M. and Peltz, G. In Silico and In Vitro Pharmacogenetics: Aldehyde Oxidase Rapidly Metabolizes a P38 Kinase Inhibitor. The Pharmacogenetics Journal (2011), 11: 15-24.



H.-H. Liu, P. Lu, Y. Guo, E. Farrell, X. Zhang, M. Zheng, B. Bosano, Z. Zhang, J. Allard, G. Liao, S. Fu, J. Chen, K. Dolim, A. Kuroda, J. Usuka, J. Cheng, W. Tao, K. Welch., Y. Liu, J. Pease, S.A. de Keczer, M. Masjedizadeh, J.-S. Hu, P. Weller, T. Garrow, and G. Peltz. Bhmt2 is a Genetic Susceptibility Factor For Acetaminophen-Induced Liver Toxicity. Genome Research, 20:28-35, 2010.

L. Gong, D. Hirschfeld, Y-C. Tan, J. H. Hogg, G. Peltz, Z. Avnur, P. Dunten. Discovery of potent and bioavailable GSK-3b inhibitors (2010). Bioorganic & Medicinal Chemistry Letters, 20:1693–1696.

X. Zhang, H-H. Liu, P. Weller, M. Zheng, J. Wang, G. Liao, M. Monshouwer and G. Peltz. In Silico and In Vitro Pharmacogenetics: Aldehyde Oxidase Rapidly Metabolizes a P38 Kinase Inhibitor.  The Pharmacogenomics Journal, In Press, 2010.

X. Li, P. Sahbaie, M. Zheng, J. Ritchie, G. Peltz, J.S. Mogil and J. D. Clark. Expression Genetics Identifies Spinal Mechanisms Supporting Formalin Late Phase Behaviors. Molecular Pain, 6:11, 2010.

M. Zheng, P. Ravindran, J. Wang, D. Chen, A. Butte and G. Peltz. An Optimistic Prognosis for the Clinical Utility of Laboratory Data. Anesthesia & Analgesia In press, 2010.

Y. Hu, D. Liang, X. Li, H-H. Liu, Xun Zhang, M. Zheng, D. Dill, X. Shi, Y. Qiao, D. Yeomans, B. Carvalho, M.S. Angst, J.D. Clark, G. Peltz. The Role of IL-1 in Wound Biology Part I: Murine in Silico and In vitro Experimental Analysis. Anesthesia & Analgesia In press, 2010.

Y. Hu, D. Liang, X. Li, H-H. Liu, Xun Zhang, M. Zheng, D. Dill, X. Shi, Y. Qiao, D. Yeomans, B. Carvalho, M.S. Angst, J.D. Clark, G. Peltz. The Role of IL-1 in Wound Biology Part II: In vivo and Human Translational Studies. Anesthesia & Analgesia.
In press, 2010.

J.S. Tregoning, Y. Yamaguchi, B. Wang, D. Mihm, J.A. Harker, E.S.C. Bushell, M. Zheng, G. Liao, G. Peltz and P.J.M. Openshaw. Genetic Susceptibility to the Delayed Sequelae of RSV Infection is MHC-Dependent, but Modified by Other Genetic Loci. J. Immunol. In press, 2010.



Chu, L., Liang, D,L., Li, X., Sahbaie, P., D’Arcy, N., Liao, G., Peltz, G. and J. D, Clark.  From Mouse to Man: The 5HT3 Receptor Modulates Physical Dependence on Narcotic Drugs.  Pharmacogenetics and Genomics, 19:193-205, 2009.

M.L. LaCroix-Fralish, S.B. Smith, G. Mo, S.G. Sotocinal, J. Ritchie, J.-S. Austin, K. Melmed, T.H. Lee, D. Romanovsky, G. Liao, M.A. Behlke, D. J. Clark, G. Peltz, P. Séguéla, M. Dobretsov and J.S. Mogil. Genetic Variation within the b3 Subunit (Atp1b3) of the Na+,K+-ATPase Alters Inflammatory Pain Sensitivity. Pain, 144:294-302, 2009.

M. Zheng, S. Shafer, G. Liao, H-H Liu, and G. Peltz. Computational Genetic Mapping in Mice: ‘The Ship has Sailed.’ Science Translational Medicine. 1, 3ps4, 2009.



E.Y. Kim, J.T. Battaile, A.C. Patel, E. Agapov, M.H. Grayson, Y. You, Y. Alevy, J. Tucker, S. Swanson, J.W. Tyner, J.D. Morton, M.Castro, G.A. Patterson, J.C. Woods, G. Reto, A. Schwendener, J.D. Allard, G. Peltz, and M.J. Holtzman (2008). Persistent activation of an innate NKT cell-macrophage immune axis translates respiratory viral infection into chronic inflammatory lung disease. Nature Medicine, 14:633-40, 2008.

Aimee Zaas, Guochun Liao, Jason Chien, Jonathan Usuka, Clarice Weinberg, David Shore, Steven Giles, Kieren Marr, Lauranell Burch, Lalith Perara, John Perfect, Gary Peltz, David Schwartz. Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis (2008).  PLOS Genetics, 4: 1-8, 2008.

Sabsovitch, I., Clark, J.D., Liao, G., Peltz, G., Lindsey, D.P., Jacobs, J.R., Yao, W., Guo, T-Z., W.S. Kingery.  Bone Microstructure and its Associated Genetic Variability in 12 Inbred Mouse Strains: µCT Study and In Silico Genome Scan. Bone, 42:439-51, 2008.

S.B. Smith, C.L. Marker, C. Perry, S.G. Sotocinal, J.-S. Austin, K. Melmed, G. Liao, G. Peltz, D.J. Clark, K. Wickman, and J.S. Mogil. Quantitative Trait Locus and Computational Mapping Identifies Kcnj9 (GIRK3) as a Candidate Gene Affecting Analgesia from Multiple Drug Classes (2008), Pharmacogenetics and Genomics, 18:231-41, 2008.

G. Liao, X. Zhang, J.D. Clark, G. Peltz.  A Genomic ‘Roadmap’ to ‘Better’ Drugs (2008).  Drug Metabolism Reviews, 40:225-39, 2008.

Moffett, S. P., Oakley, J. I., Cauley, J. A., Lui, L. Y., Ensrud, K. E., Taylor, B. C., Hillier, T. A., Hochberg, M. C., Li, J., Cayabyab, S., Lee, J. M., Peltz, G., Cummings, S. R., Zmuda, J. M. Osteoprotegerin Lys3Asn Polymorphism and the Risk of Fracture in Older Women. Journal of Clinical Endocrinology and Metabolism.  93: 2002-8, 2008.

G.J. Tranah, B.C. Taylor, Li-Y. Liu, J.M. Zmuda, J.A. Cauley, Kristine E. Ensrud, T.A. Hillier, M.C. Hochberg, J. Li, Brian Rhees, H. Erlich, M.D. Sternlicht, G. Peltz, and S. R.
Cummings, for the SOF Research Group (2008).  A candidate gene study of fracture risk and bone mineral density: results from the Study of Osteoporotic Fractures. Calcified Tissue International.  83:155-166.

Hiroshi Suemizu, Masami Hasegawa, Kenji Kawai, Kenji Taniguchi, Makoto Monnai, Masatoshi Wakui, Makoto Suematsu, Mamoru Ito, Gary Peltz and Masato Nakamura (2008).  Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice.  Biochemical Biophysical Research Communications, 377:248-252.



Yingying Guo, Erin Farrell, Peng Lu, Paul Weller, Jianmei Wang, Guochun Liao, Zhaomei Zhang, Steven Hu, John Allard, Steve Shafer, Jonathan Usuka, and Gary Peltz.  In silico and In vitro Computational Pharmacogenetics in mice.  Proceedings of the National Academy of Science (USA), 104:17735-40, 2007.

J.G. Koch, X. Gu, Y. Han, A. El-Naggar, D. Medina, D. J. Jerry, A. C. Blackburn, G. Peltz, C. Amos, and G. Lozano.  Mammary tumor modifiers in BALB/cJ mice heterozygous for p53.  Mammalian Genome, 18:300-309, 2007.

A.C. Blackburn, Hill, L.Z., Roberts A., Wang, J., Aud, D., Jung, J., Nikolcheva, T., Allard, J., Otis, C.N., Cao, J., Ricketts S.J.R., Naber, S.P., Dickinson E., Peltz, G.,  and D.J. Jerry. Low DMBT1 Expression Correlates with Breast Cancer Susceptibility in Mice and Humans. Am. J. Pathology, 170:2030-2041, 2007.

Cascio,  M., Xing, Y., Gong, D., Popovich, J., Eger, E., Saunak Sen, Peltz, G., Sonner, J.M.  Mouse chromosome 7 harbors a quantitative trait locus for isoflurane minimum alveolar concentration.  Anesthesia and Analgesia, 105: 381-385, 2007.

Moffett, S.P., Zmuda, J.M., Cauley J.A., Ensrud K.E., Hillier T.A., Hochberg M.C., Li J., Cayabyab S., Lee J. M, Peltz G., Cummings S.R. Association of the VDR translation start site polymorphism and fracture risk in older women. Journal of Bone and Mineral Research, 22: 730-6, 2007.

Adachi, K., Mirzadeh, Z., Sakaguchi, M., Yamashita. T., Nikolcheva, T., Peltz, G., Gong, L., Gotoh, Y., Alvarez-Buylla, A., Kawase,  T., Okano, H., and Sawamoto, K.  b-catenin Signaling Promotes Proliferation of Progenitor Cells in the Adult Mouse Subventricular Zone.  Stem Cells, 25: 2827-36, 2007.

Zheng, M., Lu, P., Liu, Y., Pease, J., Usuka, J., Peltz, G., and Guochun Liao.  An Automated Method for Analysis of 2-Dimensional 1H-13C NMR Spectra (2007). Bioinformatics, 21:2926-2933.

Sabsovitch, I., Clark, J.D., Liao, G., Peltz, G., Lindsey, D.P., Jacobs, J.R., Yao, W., Guo, T-Z., W.S. Kingery.  Bone Microstructure and its Associated Genetic Variability in 12 Inbred Mouse Strains: µCT Study and In Silico Genome Scan. Bone, 42:439-51, 2008.



Guo, Y., Weller, P., Farrell, E., Cheung, P.,  Fitch, B., Clark, D., Wu,S.-Y., Wang, J., Liao, G., Zhang, Z., Allard, J., Cheng, J., Nguyen, A., Jiang, S., Shafer, S., Usuka, J., Masjedizadeh, M. and G. Peltz.  In Silico Pharmacogenetics: Warfarin Metabolism. Nature Biotechnology, 24: 531-536, 2006.

D-Y. Liang, G. Liao, G. Lighthall, G. Peltz and J. D. Clark (2006). Genetic Variants of the P-Glycoprotein Gene Abcb1b Modulate Opioid-Induced Hyperalgesia, Tolerance and Dependence. Pharmacogenetics and Genomics, 16: 825-835, 2006.

Liang, D., Liao, G., Wang, J., Usuka, J., Gou, J., Peltz, G. and Clark, D.J.  Genetic Analysis of Opioid-Induced Hyperalgesia in Mice. Anesthesiology, 104: 1054-1062, 2006.

A.C. Patel J.D. Morton, E.Y. Kim, Y. Alevy, S. Swanson, J. Tucker, G. Huang, E. Agapov, T.E. Phillips, J.D. Allard, K. Dabbagh, G. Peltz, and M.J. Holtzman.  Genetic segregation of airway disease traits despite redundancy of chloride channel calcium-activated (CLCA) family members.  Physiological Genomics.  25: 502-513, 2006.

D.Y. Liang, T. Guo, G. Liao, W. Kingery, G. Peltz and J.D. Clark.  Chronic Pain and Genetic Background Interact and Influence Opioid Analgesia, Tolerance and Physical Dependence.  Pain. 121: 232-240, 2006.

Y. Guo, P. Weller, J. Allard, J. Usuka, M. Masjedizadeh, S-Y. Wu, B. Fitch, D. Clark, J.D. Clark, S. Shafer, J. Wang, G. Liao and G. Peltz.  Understanding Our Drugs and Our Diseases.  Proceedings of the American Thoracic Society.  3: 409-412, 2006.



Wang, J.; Liao,G.; Usuka, J.; Peltz, G.  Computational Genetics: From Mouse to Man? Trends in Genetics. 21: 526-532, 2005.

Wang,J.; Liao,G.; Chang,J.; Nguyen,A.; Guo,J.; Chou,S.; Hu,S.; Bach,C.; Allard,J.; Shafer,S.; Puech,A.; McPherson,J.D.; Foernzler,D.; Peltz,G.; Usuka,J.  Haplotypic Structure of the Mouse Genome.  Chapter 4 in Computational Genetics: New Tools for Disease Biology.  G. Peltz, editor. Trenton: Humana Press, 2005.

Peltz, G.  Computational Biology Are We There Yet? Chapter 1 in Computational Genetics: New Tools for Disease Biology.  G. Peltz, Editor. Trenton: Humana Press, 2005.

Wang, J., Peltz, G. Haplotype-Based Computationa Genetic Analysis in Mice. Chapter 3 in Computational Genetics: New Tools for Disease Biology.  G. Peltz, Editor. Trenton: Humana Press, 2005.

Usuka, J.; Peltz, G. From Mouse Genetics to Human Therapeutics.  Current Opinion in Drug Discovery and Development. 8: 253, 2005.

Moffett, S.P.; Zmuda, J.M.;  Oakley, J.M.; Beck, T.J.; Cauley, J.A.,Stone,K.L., Lui,L.Y.;Ensrud, K.E., Hillier,T.A., Hochberg, M.A.; Morin,P.; Peltz, G; Greene,D.; Cummings, S.R.Tumor Necrosis Factor Alpha Polymorphism, Bone Strength Phenotypes, and the Risk of Fracture in Older Women.  J. Clin. End. Metab. 90: 3492-3497, 2005.

Guo, Y.; Shafer, S.: Usuka, J.; Peltz, G. The Pharmacogenomic Road Ahead.  Pharmacogenetics.  6:857-864, 2005.



Wang,J.; Liao,G.; Chang,J.; Nguyen,A.; Guo,J.; Chou,S.; Hu,S.; Allard,J.; Shafer,S.; Puech,A.; McPherson,J.D.; Foernzler,D.; Peltz,G.; Usuka,J.  In Silico Genetics: Identification of A Novel Functional Element Regulating H2-Ea Gene Expression.  Science 306:690-96, 2004.

Klein,R.F.; Alard,J.; Avnur,Z.; Nikolcheva,T.; Rotstein,D.; Carlos,A.S.; Shea,M.; Waters,R.V.; Belknap,J.K.; Peltz,G.; Orwoll,E.S.  Regulation of Bone Mass in Mice by the Lipoxygenase Gene Alox15Science.  303:229-232, 2004.

Savov, J.D., Whitehead,G.S., Foster,W.M.,Wang,J.,Liao,G., Usuka,J., Peltz,G., Schwartz,D.A.  O3-Induced Acute Pulmonary Injury in Inbred Mouse Strains.  Am. J. Resp. Cell Mol. Biol., 31: 69-77, 2004.



Karp,C.L.; Grupe,A.; Schadt,E.; Ewart,S.; Keane-Moore,M.; Cuomo,P.J; Kohl,J.; Wahl,L.; Kuperman,D.; Germer,S.; Aud,D.; Peltz,G.; Wills-Karp,M. Identification of Complement Factor 5 (C5) as a Susceptibility Factor for Experimental Allergic Asthma.  Nature Immunology. 1:221, 2000.

Grupe,A.; Germer,S.; Usuka,J; Aud,D.; Belknap,J.K.; Klein,R.F.; Ahluwalia,M.K.; Higuchi,R.; Peltz,G. In Silico Mapping of Complex Disease-Related Traits in Mice. Science.  292:1915, 2001.

Ewert,S.; Kuperman,D.; Schadt,E.; Tankersley,C.; Grupe,A.; Shubitowski,D.M.; Peltz,G.; Wills-Karp,M. Quantitative Trait Loci Controlling Allergen-Induced Airway Hyperresponsiveness in Inbred Mice. Am J Respir Cell Mol Biol.  23: 537-45, 2000.

Rozzo,S; Allard,J.D;Choubey,D; Vyse,T.;Izui,S.;Peltz,G.;Kotzin,B.L.  Evidence for an interferon-inducible gene, ifi202, in the susceptibility to Systemic Lupus.  Immunity.  15:1,2001.

Noble, J.A., White, Amy, M., Lazzeroni, L.C., Valdes, A.M., Mirel, D.B., Reynolds, R., Grupe, A., Aud, D., Peltz, G., Erlich, H.A. (2003).  A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. Diabetes. 52: 1579-82.


20th Century

Liu, H.-Y., Peltz, G.A., Leytus, S.P., Livingston, C., Brocklehurst, J., Mangel, W.F.. Sensitive assay for plasminogen activator of transformed cells. Proc. Natl. Acad. Sci (USA) 77:3796-800, 1980.

Mangel, W.F., Livingston, D.C., Brocklehurst, J.R., Liu, H.-Y., Peltz, G.A., Cannon, J.F., Leytus, S.P., Wehrly, J.A., Salter, B.L., Mosher, J.L. New assay for the plasminogen activator activity of transformed cells. Cold Spring Harbor Symposia on Quantitative Biology 44(1):669-80, 1980.

Mangel, W.F., Livingston, D.C., Brocklehurst, J.R., Cannon, J.F., Leytus, S.P., Peltz, S.W., Peltz, G.A., Liu, H.-Y. A new active-site titrant of serine proteases. Methods in Enzymology 80 Pt C:414-24, 1981.

Leytus, S.P., Peltz, G.A., Liu, H.-Y., Cannon, J.F., Peltz, S.W., Livingston, D.C., Brocklehurst, J.R., Mangel, W.F. A quantitative assay for the activation of plasminogen by transformed cells in situ and by urokinase. Biochemistry 20:4307-14, 1981.

Livingston, D.C., Brocklehurst, J.R., Cannon, J.F., Leytus, S.P., Wehrly, J.A., Peltz, S.W., Peltz, G.A., Mangel, W.F. Synthesis and characterization of a new fluorogenic active-site titrant of serine proteases. Biochemistry 20:4298-306, 1981.

Peltz, G., Kuczmarski, E. and J. Spudich.  Dictyostelium myosin: characterization of chymotryptic subfragments and localization of a heavy chain phosphorylation site.  J. Cell Biol. 89:104‑108, 1981.

Flicker, P., Peltz, G., Sheetz, M., Parham, P. and J. Spudich.  Site‑specific inhibition of myosin‑mediated motility in vitro by monoclonal antibodies.  J. Cell Biol. 100:1024‑1030, 1985.

Peltz, G., Spudich, J.A., Parham, P. Monoclonal antibodies against seven sites on the head and tail of Dictyostelium myosin. The Journal of Cell Biology 100:1016-23,1985.

Peltz, G.A., Gallis, B., Peterlin, B.M. Monoclonal antibody immunoprecipitation of cell membrane glycoproteins. Analytical Biochemistry 167:239-44, 1987.

Peltz, G., Trounstein, M. and K. Moore.  Cloned and expressed human Fc RII mediates anti‑CD3 induced lymphoproliferation.  J. Immunol. 141:1891‑1896, 1988.

Grundy, H.O., Peltz, G., Moore, K.W., Golbus, M.S., Jackson, L.G., Lebo, R.V. The polymorphic Fc gamma receptor II gene maps to human chromosome 1q. Immunogenetics29:331-9,1989.

Peltz, G., Grundy, H., Lebo, R., Yssel, H., Barsh, G. and K. Moore.  Human Fc RIII: cloning, expression and identification of the chromosomal locus of two Fc receptors for IgG.  Proc. Natl. Acad. Sci. 86:1013‑1017, 1989. 

Peltz, G., Frederick, K., Anderson, C.L., Peterlin-B.M. Characterization of the human monocyte high affinity Fc receptor (hu FcRI). Molecular immunology 25:243-50,1988.

Trounstine, M.L., Peltz, G.A., Yssel, H., Huizinga, T.W., von dem Borne,A.E., Spits, H., Moore, K.W. Reactivity of cloned, expressed human Fc gamma RIII isoforms with monoclonal antibodies which distinguish cell-type-specific and allelic forms of Fc gamma RIII.  International Immunology 2:303-10, 1990.

Mensi, N., Webb, D.R., Turck, C.W., Peltz, G.A.  Characterization of Borrelia burgdorferi proteins reactive with antibodies in synovial fluid of a patient with Lyme arthritis. Infection and Immunity 58:2404-7, 1990.

Yssel, H., Nakamoto, T., Schneider, P., Freitas, V., Collins, C., Webb, D., Mensi, N., Soderberg, C., Peltz, G. Analysis of T lymphocytes cloned from the synovial fluid and blood of a patient with Lyme arthritis. International Immunology 2:1081-9,1990.

Yssel, H., Shanafelt, M.-C., Soderberg, C., Schneider, P., Anzola, J., and G. Peltz.  B. burgdorferi activates a TH1-like T cell subset in Lyme arthritisJ. Exp. Med. 174:593-601, 1991.

Shanafelt, M.C., Hindersson, P., Soderberg, C., Mensi, N., Turck, C.W., Webb, D., Yssel, H., Peltz, G.   T cell and antibody reactivity with the Borrelia burgdorferi 60-kDa heat shock protein in Lyme arthritis.  Journal of Immunology 146: 3985-92, 1991.

Peltz, G. A role for CD4+ T cell subsets producing a selective pattern of lymphokines in the pathogenesis of human chronic inflammatory and allergic diseases. Immunol. Rev. 123:23-35, 1991.

Collins, C., Peltz, G.  Immunoreactive epitopes on an expressed recombinant flagellar protein of Borrelia burgdorferi. Infection and Immunity 59:514-20, 1991.

Shanafelt, M.C.,  Anzola, J., Soderberg, C., Yssel, H., Turck, C., and G. Peltz. Epitopes on the outer surface protein A of Borrelia burgodorferi recognized by antibodies and T cells of Lyme arthritis patients.  J. Immunol. 146:3985-3992, 1992.

Anzola, J., Luft, B.J., Gorgone, G., Peltz, G. Characterization of a Borrelia burgdorferi dnaJ homolog. Infection and Immunity 60:4965-8, 1992.

Anzola, J., Luft, B.J., Gorgone, Dattwyler, R.J., Soderberg C., Lahesmaa, R., Peltz, G. Borrelia burgdorferi HSP70 homolog: characterization of an immunoreactive stress protein. Infection and Immunity 60:3704-13 1992.

Lahesmaa, R., Yssel, H., Batsford, S., Luukkainen, R., Möttönen, T., Steinman, L., Peltz, G.
Yersinia enterocolitica activates a T helper type 1-like T cell subset in reactive arthritis.  Journal of Immunology 148:3079-85, 1992.

Lahesmaa, R, Shanafelt, M.C., Steinman, L., Peltz, G.  Immunopathogenesis of human inflammatory arthritis: lessons from Lyme and reactive arthritis. J. Inf. Dis. 170:978-85, 1994.

Begovich, A.B., Klitz, W., Moonsamy, P.V., Van de Water J., Peltz, G., Gershwin, M.E. Genes within the HLA class II region confer both predisposition and resistance to primary biliary cirrhosis. Tissue Antigens 43: 71-7, 1994.

Lahesmaa, R., Soderberg, C., Bliska, J., Leirisalo-Repo, M., Luukkainen, R., Steinman, L., and G. Peltz. Pathogen antigen and superantigen-responsive T cells in reactive arthritis. J. Inf. Dis.  172:1290-97, 1995.

Shanafelt, M-C., Soderberg, C., Allsup, A., Adelman, D., Peltz, G., and Lahesmaa, R. Costimulatory signals can selectively modulate cytokine production by CD4+ T cells.  J. Immunol.  154:1684-90, 1995.

Jackman, J., Motto, D., Sun, Q., Tanemoto, M., Turck,C.W., Peltz, G.A., Koretzky, G.A., Findell, P.R.  Molecular  cloning of SLP76, a 76 kDa tyrosine phosphoprotein associated with Grb2 in T cells.  J. Biol. Chem. 240:2029-32, 1995.

Lahesmaa, R., Shanafelt, M.C., Allsup, A., Soderberg, C., Anzola, J., Freitas, V., Turck, C., Steinman, L., Peltz, G.  Preferential usage of T cell antigen receptor V region gene segment V beta 5.1 by Borrelia burgdorferi antigen-reactive T cell clones isolated from a patient with Lyme disease.  Journal of Immunology 150: 4125-35, 1993.

Shanafelt, M-C., Yssel, H.,  Soderberg, C., Steinman, L., Adelman, D., Peltz, G., and R. Lahesmaa.  CD45 isoforms on human T cell subsets.  J. Allergy Clin. Immunol. 98:433-40, 1996.

Lahesmaa,R., Allsup,A., Soderberg, C., Jackman, J., Findell, P., and G. Peltz.  Modulation of the grb2-associated protein complex in human CD4+ Tcells by receptor activation. J. Immunol. 155:3815-22, 1995.

Turcovski-Corrales,S.M., Fenton, R.G., Peltz., G, Taub, D.D. CD28:B7 interactions promote T cell adhesion. European Journal of Immunology 25:3087-93,1995.

Peltz,G.  Transcription factors in immune-mediated disease.  Current Opin. Biotech. 8:467-73, 1997.

Ranganath S. Ouyang WJ. Bhattarcharya D. Sha WC. Grupe A. Peltz G. Murphy KM (1998) Gata-3-dependent enhancer activity in IL-4 gene regulation. Journal of Immunology161, 3822-3826.

Guler ML. Gorham JD. Dietrich WF. Murphy TL. Steen RG. Parvin CA. Fenoglio D. Grupe A. Peltz G. Murphy KM. (1999) Tpm1, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism. Journal of Immunology 162, 1339-1347.

Ranganath,S.; Ouyang,W.; Bhattarcharya,D.; Sha,W.C.; Grupe,A.; Peltz,G.; Murphy,K.M. GATA-3-dependent enhancer activity in IL-4 gene regulation.  J. Immunol.   161:3822-26,1998.

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