Peltz Lab In the Department of Anesthesia

Lab Members

labmembers

 


Gary Peltz (P.I.)

Peltz


Dr. Bill Fitch, Ph.D., Visiting Professor
fitch

Research interest: Dr. Fitch received his Ph.D in Organic Mass Spectrometry from Stanford in 1974, and has 35 years of industry experience in biomedical and related applications of mass spectrometry. He has evaluated, purchased, installed, and used over 30 high-end mass spectrometers during his long career as head of Drug Metabolism at Roche.  Dr. Fitch has over 50 peer-reviewed publications.  His published work covers basic studies on ion chemistry as well as qualitative and quantitative applications of mass spectrometry in the natural product, environmental, clinical and drug metabolism fields. In recent years, his focus has been on mass spectral structure determination of drug metabolites and identification of reactive drug metabolites.  He also teaches and lectures on the applications of mass spectrometry at UC Santa Cruz and to other professional groups.

 


Dr. Toshi Nishimura, M.D., Ph.D., Visiting Professor and Research Associate
toshi

Dr. Nishimura is a trained surgeon with a vast amount of experience with transgenic animal production and in developing animal models of human disease.  He is a major driver in the project that is producing mice with ‘humanized’ livers.

 


Manhong Wu, Ph.D., Research Associate
toshi

Research interest: Dr. Wu received her Ph.D. from the University of British Columbia, and was a post-doctoral fellow and instructor at the U. of Washington, Seattle. At the Baylor College of Medicine, she managed the Mass Spec facility that performed proteomic and metabolite analysis in critically ill children.  In the Peltz lab, she is responsible for mass spectroscopy and metabolomic analysis, and has 8 years of experience with projects utilizing mass spectroscopy. 

 


Ming Zheng, Ph.D., Research Associate
ming

Research interest: Development and applications of statistical modeling and machine learning in biological data to facilitate candidate selection and scientific discovery. Statistical analysis in biological and biomedical data: sequence analysis, microarray data analysis, ChIP-chip data analysis, analysis of haplotypic block structure in human and model organism and association study.

 


Dan Xu, Ph.D., Research Associate
Dan

Research interest: My research interest is producing mice with 'humanized' livers using embryonic stem cell (ESCs) and induced pluripotent cells (iPSC) derived hepatic progenitor cells and hepatocyte. Ultrasound directed injection is used in transplantation process, in order to generate stabilized humanized mouse model for further drug selection and drug metabolites research.

 


Haili Zhang, Ph.D., Research Associate
Haili

My research interest is to use forward genetic approaches to identify genetic factors underlying variations of biomedical traits in the mammalian model organism of mouse (Mus musculus). Thousands of biomedical traits show remarkable inter-strain differences among 20-30 inbred mouse strains (phenome.jax.org). 36 mouse inbred strain genomes have been recently sequenced by the Peltz lab, revealing genetic variation of over 18 million SNPs. By using haplotype-based genome-wide association mapping method, we looked for what genetic regions are significantly associated with the phenotype differences. We then used various genetics, functional genomics, molecular and metabolic approaches to identify and verify the causative genes and genetic changes. My current project involves finding genetic factors underlying antipsychotic drug induced neuronal disorders. A novel drug-efflux transporter and an enzyme involved in pantethine metabolism appeared to be the two major genetic factors affecting drug haloperidol induced motor disorders.

 


Fangjun Jia, Ph.D., Research Associate
Fangun

Research Interest: Developing the tools for human genome editing, manipulating of human genes, either gene correction or knockin, to establish the platform for modeling of human disease or therapeutic drug evaluation on human induced pluripotent stem cells.

 


Current Trainees

Yuan Guan, Ph.D., Postdoctoral Fellow
Guan

Research interest: My research interests are mainly focused on the area of translational research including study the role of signaling in tumorigenesis and therapeutic function of ESC derivatives, pluripotent stem cell for regeneration medicine and gene therapy for inherited as well as degenerative diseases. Recent project is creation of an experimental platform for studying human liver and pancreas development and function, which utilizes iPS cells generated from individuals with genetic disease. We also use mouse with humanized organ carrying specific mutations to provide a better physiologic model for these diseases.

 

 

 

 


Collaborators

David L. Dill, Ph.D.

dill

Dr. David Dill is a Professor of Computer Science at Stanford and has authored 150 papers.  He has decades of experience inventing new techniques for analyzing large systems, including discovering relationships in very large amounts of gene expression data. His is a key collaborator that is developing and implementing highly efficient algorithms for construction of a high-resolution haplotype map and computational genetic analysis of phenotypic data, and a metabolomic network analysis program.

 

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