Third Year Fellow
Xin (Cissy) Si, MD
Elizabeth and Russell Siegelman Postdoctoral Fellow
Medical School: Baylor College of Medicine
Residency Program: Med-Peds at Rainbow Babies and Children's Hospital
Mentor: Carlos Milla, MD
Research: Nontuberculous mycobacteria are an increasingly problematic group of organisms in the cystic fibrosis population and pulmonary disease exists on a spectrum from pure colonization to active, progressive end stage disease. The neutrophilic inflammation and dysfunction in the CF airway likely plays a major role in NTM disease susceptibility and progression in addition to the commonly perceived macrophage dysfunction underlying NTM disease. The goal of my research is to better characterize the host-inflammatory response to NTM in the CF airway by analyzing sputum cytokine expression levels, neutrophil elastase activity, and neutrophil functional assays in different subsets of NTM colonized patients, which can help identify patient at risk for severe NTM lung disease early on.
Prior Experience: I entered into Internal Medicine/Pediatrics with an interest in primary care and the desire to truly embrace continuity of care. In residency, I was drawn to the complexity of chronic diseases and the systemic effect that respiratory diseases can have. These interests have drawn me to the field of pulmonology, and in particular, to those affected by cystic fibrosis. I hope to further these interests at Stanford and learn how to be a specialist with a primary care focus.
Second Year Fellows
Nazia Hossain, DO
Medical School: Touro University Nevada College of Osteopathic Medicine
Residency Program: Madigan Army Medical Center
Mentor: Christin Kuo, MD
Research: Congenital pulmonary malformations (CPAMs) are rare anomalies of fetal lung development, historically classified by descriptive imaging studies, but little is known about the molecular pathogenesis. Routine prenatal imaging studies have resulted in early detection of a spectrum of congenital pulmonary lesions with heterogeneous lesions. Resection of virtually all identified lesions is the general standard of care, yet we know little about the underlying developmental defects and consequently have not able to individualize management. My research aims to molecularly identify the cell types and quantify their numbers and distribution along the tracheobronchial tree in the normal and diseased portions of resected congenital pulmonary malformations. In addition, I aim to phenotype a cohort of patients with congenital pulmonary lesions identified prenatally and map the trajectory of individual lesions by a combination of imaging, and histologic changes, and clinical presentation.
As an active-duty US Army officer, I am primarily motivated in pursuing a career in humanitarian and operational medicine. Throughout residency, I have been exposed to the challenges of treating military children with complex needs. By pursuing a fellowship in pediatric pulmonology, I hope to gain an unique set of skills to manage chronic respiratory diseases in austere environments with limited access to sub-specialty care. After learning to embrace the gloom of the Pacific Northwest during residency, I am eager to return to the sunshine of my home state. I love being outdoors and enjoy kayaking and exploring new trails. Most importantly, as a Warriors loyalist, I'm excited to be able to support my team as a local.
Ian Lee, MD
Ernest and Amelia Gallo Endowed Postdoctoral Fellow
Medical School: Saint Louis University School of Medicine
Residency Program: University of California (Irvine)/Children's Hospital of Orange County
Mentor: Purvesh Khatri, PhD
Research: Asthma has a significant burden upon millions of people and children in the world, and particularly severe asthma which is poorly control despite treatment. Asthma is a heterogeneous disease with many people with different levels of severities, different triggers, and different responses to medications. Recent research has identified specific pathways in some people with asthma that has led to development of targeted treatments for their asthma. However, for many others the underlying biology remains unclear. The goal of my research is to use unbiased meta-analysis approach to integrate publically available gene expression data collected from patients with asthma to identify a gene signature to help distinguish different populations of severe asthma and potentially identify the pathways which might suggest the underlying mechanisms involved and identify individuals who will progress to severe asthma. By integrating data from multiple studies, our research leverages the heterogeneity that exists between study populations and techniques to generate results that are generalizable and more reflective of real world populations.
Prior Experience: I grew up in Pasadena, CA (home to the Rose Bowl, JPL, and Julia Child) then attended college at Johns Hopkins University, medical school at Saint Louis University, and residency at UCI/Children’s Hospital of Orange County. I have enjoyed working with medically complex patients and their families both in the clinic when life is going well and, in the hospital, when things are at the more challenging medically and emotionally. I love being active and am an amateur weightlifter, love watching (and thinking too much about) movies and television shows, and spending time with my wife.
Nina Suresh, MD, MS
Ernest and Amelia Gallo Endowed Postdoctoral Fellow
Medical School: University of Massachusetts Medical School
Residency Program: New York-Presbyterian Hospital, Weill Cornell Medical Center
Mentor: Cristina Alvira, MD
Research: The lung continues to develop throughout the first decade of life, and this process is disrupted in diseases such as bronchopulmonary dysplasia. While the complex molecular mechanisms of lung development are incompletely understood, data suggest that angiogenesis is a key driver of alveolarization. The goal of my research is to utilize single-cell RNA sequencing to determine the role of transcriptionally discrete lung mesenchymal populations in directing pulmonary vascular growth and remodeling during alveolarization, and to assess how these mechanisms are disrupted by stimuli that impair alveolar and vascular growth.
Prior Experience: During residency, I was drawn to the complex pathophysiology of respiratory diseases and the efficacy of preventive care for these complex patients. My decision to pursue a fellowship in pediatric pulmonology was driven by my interest in severe asthma and the wide range of clinical experience involved in caring for these patients, from consults on critically ill asthmatics to the importance of preventive care in the outpatient setting. I look forward to further exploring these interests during fellowship. I have spent most of my life on the East Coast, having grown up in the suburbs of Boston, attended MIT for college, UMass for medical school, and NYP Cornell for residency. I have always wanted to live in California, and I’m so excited to explore the West Coast. In my free time, I enjoy running, dance cardio classes, traveling, and learning Spanish.
First Year Fellows
Jessica Bradford, MD, MPH
Medical School: University of Alabama
Residency Program: Cohens Children's, NY
Prior Experience: Since college I have actively engaged in efforts to alleviate health disparities among vulnerable populations. Throughout residency I was part of a community pediatrics advocacy track and also developed a wellness curriculum for our program. I am now so excited to pursue my interests in health disparities research of asthma and cystic fibrosis as well as expanding my knowledge about how to implement advocacy and wellness efforts during fellowship.
Lori Lee, MD, PhD
Medical School: Stanford
Residency Program: Lucile Packard Children's Hospital Stanford
Prior Experience: My interest in Pediatric Pulmonology stems from the pathophysiology of pediatric pulmonary condition, opportunities to serve a diverse patient population in a both the acute/intensive care and outpatient settings, and opportunities to advance patient care through research. My career goal is to obtain an academic position as a physician-scientist in Pediatric Pulmonology. Through fellowship training, I hope to deepen my clinical training in pediatric pulmonary medicine, establish the foundation for future research endeavors, and hone skills in mentoring and teaching.