Grimm Lab

Paul Grimm, MD

Dr. Paul Grimm is the Fellowship Program Director, and has conducted basic and clinical research in renal disease.  He is the Medical Director of the Cystinosis Clinic, and the Pediatric Kidney Transplant Program.  He is currently the PI of a safety and effectiveness study of cysteamine in patients with cystinosis, and a Phase 2 multicenter clinical trial to evaluate the pharmacokinetics and efficacy of belatacept in transplant recipients.  Under Dr. Grimm’s leadership, the pediatric nephrology fellows take advantage of multiple research opportunities, including completion of a master’s degree in clinical research, or working in a basic science laboratory with an adult nephrology mentor.

The problem of chronic renal and hepatic injury, especially transplant rejection and scarring is the focus of the lab using techniques of computerized image analysis, immunohistochemistry, in situ hybridization and molecular biology. Studies include translational research serving as a core lab in multi institutional clinical trials of transplant rejection and glomerulonephritis.

The lab is also looking at the origin of fibrosis in human and animal scarring models by collaboration in multicenter trials and using a rat model of kidney transplantation with subsequent analysis of the scarring process.