2019
Friday Fri
Pediatric Grand Rounds (CME)- Severe Influenza Viral Infection: Novel Vaccine and Gene Therapy Approaches
David B. Lewis - Stanford School of Medicine
An overview of influenza A pandemics and their potential threats to worldwide health. This will be followed by the current limitations of annual flu vaccines for providing protection against newly emerging strains. Three different strategies will be discussed that are being developed to provide enhanced protection against severe influenza A infection.
Speaker
David B. Lewis, MD
Chief, Stanford Department of Pediatrics, Division of Immunology and Allergy
Professor of Pediatrics - Immunology and Allergy
Session Description
An overview of influenza A pandemics and their potential threats to worldwide health. This will be followed by the current limitations of annual flu vaccines for providing protection against newly emerging strains. Three different strategies will be discussed that are being developed to provide enhanced protection against severe influenza A infection. These are all in precliinical starges of development but are promising. First, approaches to improve flu vaccination by changing the antigens and adjuvants used will be presented. Second, a gene therapy approach in which the body is harnessed to makes its own monoclonal antibodies against influenza A virus will be presented. Third a CRISPR based gene therapy approach using either catalytically inactive (dead) Cas proteins to induce innate immune protective genes against flu or CasRx proteins to cleave influenza RNA will be presented.
Education Goals
- Understand the potential danger posed by a new influenza A pandemic if it were similar in virulence to the 1918 pandemic
- Understand why developing a universal flu vaccine to protect against all influenza A virus strains has been so difficult
- Understand role of improved vaccine antigens and adjuvants in enhancing the flu vaccine
- Understand that new forms of gene therapy to produce monoclonal antibodies and to activate the innate immune system is an alternative to vaccination to prevent influenza
Location
Lucile Packard Children's Hospital, West Building Auditorium
725 Welch RoadStanford, CA 94304
CME Credit
Accreditation
The Stanford University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit Designation
The Stanford University School of Medicine designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Cultural and Linguistic Competency
California Assembly Bill 1195 requires continuing medical education activities with patient care components to include curriculum in the subjects of cultural and linguistic competency. The planners and speakers of this CME activity have been encouraged to address cultural issues relevant to their topic area. The Stanford University School of Medicine Multicultural Health Portal also contains many useful cultural and linguistic competency tools including culture guides, language access information and pertinent state and federal laws. You are encouraged to visit the portal: http://lane.stanford.edu/portals/cultural.html
Contact Stanford Center for Continuing Medical Education for CME credit transcript. Email Magna Patel, RSS Manager at magna@stanford.edu or stanfordcme@stanford.edu.
Planner and Faculty Disclosure to Learners
In accordance with the standards of the Accreditation Council for Continuing Medical Education (ACCME), all speakers, planners and/or persons who can influence the CME content must disclose to learners any relationships with commercial interests providing products or services that are relevant to the content of the presentation. The following individual(s) HAVE indicated the following relationships:
Planner
Bertil Glader, MD
Contracted Research: Agios
The following speakers, planning committee members and/or persons who can influence CME content have indicated they have NO relationships with commercial industry to disclose relevant to the content of this CME activity:
Course Director
Alan Schroeder, MD, Associate Chief for Research, Division of Pediatric Hospital Medicine
Planners
Mary Leonard, MD, MSCE, Chair Department of Pediatrics
Matthew Porteus, MD, PhD, Associate Professor, Division of Stem Cell Transplantation and Regenerative Medicine
Neville H. Golden, MD, Chief, Division of Adolescent Medicine
Lisa Chamberlain, MD, MPH, Associate Professor, General Pediatrics
Minnie Dasgupta, MD, Chief Resident, Pediatric Residency Program
Speaker
David B. Lewis, MD