October 25 Oct 25
2019
Friday Fri

Pediatric Grand Rounds (CME) - Monogenic Causes of Nephrotic Syndrome: Defining Drug Targets and Enabling Personalized Medicine Approaches

Friedhelm Hildebrandt, MD - Harvard Medical School

In this session, we will describe the rapid pace at which >60 monogenic causes of steroid resistant nephrotic syndrome (SRNS) are being discovered.

Speaker

Friedhelm Hildebrandt, MD

William E. Harmon Professor of Pediatrics,

Harvard Medical School

Chief, Division of Nephrology,

Boston Children's Hospital 

Read more

Session Description

In this session, we will describe the rapid pace at which >60 monogenic causes of steroid resistant nephrotic syndrome (SRNS) are being discovered. In addition, descriptions of all knowledge on disease mechanisms of SRNS derives from monogenic gene discovery, the coalescence of monogenic genes and proteins to functional pathways that are novel to SRNS pathogenesis, the prevalence of monogenic causes of SRNS in patient cohorts, and the very fruitful implications for a personalized medicine approach towards SRNS will be discussed and how these insights are being used to design specific drugs to treat SRNS 

Education Goals

  • Recognize the rapid emergence of hundreds of monogenic causes of chronic kidney disease
  • Understand the relationship between monogenic gene discovery and delineation of pathogenic pathways
  • Realize that in CKD that manifests before age 25 yrs a monogenic cause can be detected in ~20% of cases using whole exome sequencing
  • Consider the utility of molecular genetic diagnostics in nephrotic syndrome in relation to personalized medicine approaches to disease management

Location

Loading Map...

LPCH West Auditorium

725 Welch Road
Stanford, CA 94304
Get Directions

CME Credit

Accreditation

The Stanford University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Stanford University School of Medicine designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Cultural and Linguistic Competency

California Assembly Bill 1195 requires continuing medical education activities with patient care components to include curriculum in the subjects of cultural and linguistic competency.  The planners and speakers of this CME activity have been encouraged to address cultural issues relevant to their topic area. The Stanford University School of Medicine Multicultural Health Portal also contains many useful cultural and linguistic competency tools including culture guides, language access information and pertinent state and federal laws. You are encouraged to visit the portal: http://lane.stanford.edu/portals/cultural.html

Contact Stanford Center for Continuing Medical Education for CME credit transcript. Email Magna Patel, RSS Manager at magna@stanford.edu or stanfordcme@stanford.edu.

Planner and Faculty Disclosure to Learners

In accordance with the standards of the Accreditation Council for Continuing Medical Education (ACCME), all speakers, planners and/or persons who can influence the CME content must disclose to learners any relationships with commercial interests providing products or services that are relevant to the content of the presentation. The following individual(s) HAVE indicated the following relationships:

Planner

Bertil Glader, MD

Contracted Research: Agios

Speaker

Friedhelm Hildebrandt, MD

Advisory board member with monetary and/or other compensation - Goldfinch-Bio

Fees for speakers’ bureaus received directly from commercial interest - Blueprint Genetics

Contracted research - NIH

Ownership interest (stocks, stock options, or other ownership interest excluding diversified mutual funds) - Goldfinch-Bio stock

The following speakers, planning committee members and/or persons who can influence CME content have indicated they have NO relationships with commercial industry to disclose relevant to the content of this CME activity:

Course Director

Alan Schroeder, MD, Associate Chief for Research, Division of Pediatric Hospital Medicine

Planners

Mary Leonard, MD, MSCE, Chair Department of Pediatrics

Matthew Porteus, MD, PhD, Associate Professor, Division of Stem Cell Transplantation and Regenerative Medicine

Neville H. Golden, MD, Chief, Division of Adolescent Medicine

Lisa Chamberlain, MD, MPH, Associate Professor, General Pediatrics

Minnie Dasgupta, MD, Chief Resident, Pediatric Residency Program