Research


The Pediatric Critical Care Medicine Division prides itself on collaborative, diverse and far-reaching research, focused on studying the biology and management of critical illnesses in children.  

The Division is involved in multicenter clinical trials in collaboration with the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network and other research groups at leading academic institutions. The research efforts of the critical care faculty are supported by extramural sources such as the National Institutes of Health, the Burroughs-Wellcome Fund, the American Heart Association, the Laerdal Foundation and various industry sponsored grants.  The Stanford Child Health Research Institute also provides intramural support for ongoing research within the Division. Faculty members have mentored both clinical and postdoctoral fellows in basic science/translational, global health, quality improvement, and palliative care research.  Faculty and fellows have presented their research in both oral and poster presentation formats at national scientific meetings held by the Pediatric Academic Societies, the Society for Critical Care Medicine, the American Thoracic Society, and the Pediatric Critical Care World Congress.  Future opportunities for expanding research include broadening the breadth and depth of basic and translational research programs within the Division, and the development of a DNA biobank that could serve as a platform for genomics research in pediatric critically ill patients, fostering alignment with the Stanford School of Medicine’s goal of leading a biomedical revolution in Precision Medicine. 

 

Cristina Alvira, MD

Developmental Biology of the Pulmonary Vasculature

Dr. Alvira's lab is focused on three fundamental scientific goals: (i) identification of the signaling pathways that regulate the transition between the saccular and alveolar stages of lung development; (ii) exploration of the interplay between postnatal vascular and alveolar development; and (iii) determination of developmentally regulated pathways that mediate lung repair after injury. 

Kanwaljeet Anand, MD

Mechanisms & Management of Opiod Induced Hyperalgesia

Dr. Anand's research is focused on mechanisms and management of opioid-induced hyperalgesia, tolerance and withdrawal, and novel measures of chronic stress or pain. 

Anand Lab

David N. Cornfield, MD

Lung Biology & Pulmonary Vascular Tone

Dr. Cornfield's research focuses on chronic lung disease of Infancy, molecular regulation of pulmonary vascular tone, preterm labor, pulmonary artery endothelial cell barrier function and single cell RNA seq. 

Kevin Couloures, MD

Porcedural Sedation, Medical Education & Machine Learning

My interests are procedural sedation, medical education and machine learning of large databases.

Mihaela Damian, MD

Impact of Quality Improvement

Dr. Damian investigates the impact of Quality Improvement (QI) activities on the clinical outcomes of children in the PICU, and is currently engaged in linking these activities across the State of California, while developing ways to improve the outcomes of children undergoing solid-organ transplantation at LPCHS.  

Bereketeab Haileselassie, MD

Effects of Severe Sepsis

Dr. Haileselassie is investigating the effects of severe sepsis on myocardial strain and its underlying mechanisms. 

Peggy Han, MD

Medical Simulation and Education

Dr Han, as Director of PICU Simulation, focuses on the impact of team training and learner advancement. She also serves as the PICU ECMO Physician Lead and conducts multidisciplinary team training with high-fidelity ECMO simulations.

Gregory Hammer, MD

Pediatric Pharmacology & Perioperative Care

Dr. Hammer's primary research interests are pediatric pharmacology and perioperative care of children undergoing cardiac surgery. He has numerous funded research projects in these areas, including an NIH grant for $4.3 million to study the pharmacology of sodium nitroprusside, a drug commonly used for blood pressure control in the operating room and ICU. Dr. Hammer has two other NIH grants and other ongoing research projects in the area of pediatric pharmacology.

Saraswati Kache, MD

Development of Global Health Programs

Dr. Kache focuses her activities on developing global health programs in resource-limited countries, while improving the quality and outcomes of patients in low-income countries.

Kevin Kuo, MD

Medical Education

Dr. Kuo is interested in the development of curricula and the impact of educational interventions on learners.

Peter Meaney, MD

Pediatric Acute Care in LMICs

Dr Meaney’s research goal is to understand the factors that contribute to high quality pediatric acute care in low and middle income countries (LMICs), with a specific focus on improving healthcare worker education. His geographic focus is in East Africa.

Natalie Pageler, MD

Clinical Informatics Tools to Enhance Patient Care

Dr. Pageler, as Chief Medical Information Officer of Lucile Packard Children's Hospital Stanford (LPCHS), performs innovative research using clinical informatics tools to leverage the power of the electronic medical record and thereby enhance patient care. 

Lindsey Rasmussen, MD, FAAP

Neurocritical Care

As Co-Director of Pediatric Neurocritical Care, Dr. Rasmussen investigates inflammation following severe traumatic brain injury, outcome prediction after cardiac arrest, and neuro-monitoring in the pediatric intensive care setting.  She pursues this focus through clinical and translation studies as well as programmatic quality improvement.

Katherine Steffen, MD

Human Factors Research & Implementation Science

Dr. Steffen is focused on Implementation Science.

Felice Su, MD

Pharmacokinetics of Drugs in Clincally Ill Patients

In collaboration with Dr. Hammer in the Department of Anesthesia, Dr. Su actively pursues research to improve our understanding of the pharmacokinetics of drugs commonly used in critically ill pediatric patients, as well as novel improvements in resuscitation quality and outcomes through the ReVIVE program. 

Daniel Tawfik, MD, MS

Healthcare Provider Well-being and Quality of Care

Dr. Tawfik’s research focuses on identifying and evaluating new methods of predicting healthcare provider burnout, using biomarkers, bioinformatics, and machine learning approaches, in order to improve provider well-being and quality of care.