Behavioral Impairments in Individuals with Hypothalamic-Pituitary Disorders

Survivors of hypothalamic-pituitary brain tumors often exhibit pronounced behavioral impairments that adversely impact quality of life. No systematic research, however, has characterized these behavioral impairments in these patients or investigated the biological underpinnings. Our interdisciplinary team of basic scientists and clinicians is performing comprehensive behavioral phenotyping on these patients and testing whether disease-induced disruption to hypothalamic-pituitary signaling pathways underlie these impairments. The ultimate goal of this project is to identify “drugable” targets and to develop novel therapeutics to enhance social abilities in this patient population.