Oro Laboratory Publications


Atwood, SX, Sarin, KY, Whitson,RJ, Li, JR, Kim, G, Rezaee, M., Ally, MS, Kim, J, Yao, CY, Chang, ALS*, Oro, AE*, and Tang, JY* (2015) Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma. Cancer Cell 27:342-353  * co-senior authors. See also accompanying Preview by Ridky and Cotsarelis. 

Atwood, SX, Sarin KY, Li, JR, Yao, CY, Urman, NM, Chang, ALS, Tang, JY, and Oro AE (2015) Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug Resistant Basal Cell Carcinomas, J Invest Dermatol  doi:10.1038/jid.2015.115


Melo, S. Lisowski, L. Bashkirova, E. Zhen H. Chu K. Keene, D. Marinkovich, P. Kay, M. Oro, AE (2014) Somatic scarless correction of junctional epidermolysis bullosa by a highly recombinogenic AAV virus. Mol Therapy 22:725-33

Atwood, SX and Oro, AE (2014) “Atypical” Regulation of Hedgehog-dependent cancers Cancer Cell 25:133-4

Tang, Y. Schubert, S. Bandopadhaay, P. Bergthold, G. Nguyen, B. Masoud, S. Vue, N. Balansay B. , Yu, F., Oh, S., Chen, S. Ponnuswami, A. Monje-Diesseroth, M., Atwood, SX, Whitson RJ, Lee, A, Tang, JY, Qi, J, Beroukhim, R., Wechsler-Reya, R., Oro, AE, Bradner, JE, and Cho, YJ,  (2014)  Epigenetic Regulation of Hedgehog Pathway transcriptional output by BRD4  Nature Med 20:732-40.

Oro, AE and Watt, FM. (2014), editors. The Skin and Its DiseasesCold Spring Harbor Perspectives in Medicine CSH Press: New York.

Atwood, SX, Whitson, R., and Oro AE (2014) Advanced Basal Cell Carcinoma Therapy, in Cold Spring Harbor Perspectives in Medicine Oro AE and Watt, FM, eds.  CSH Press: New York.

Sebastiano, V, Zhen HH, Derafshi, BH, Bashkirova, L, Melo, S, Wang, P, Leung, T, Siprashvili, Tichy, A., Li,J, Ameen M., Hawkins, J., Lee, S., Li, L, Bauer, G., Lisowski, Kay, M., Kim, SK, Lane, AT, Wernig, M. and Oro, AE (2014) Corrected Induced Pleuripotent Stem Cell Based Therapy for the Treatment of Recessive Dystrophic Epidermolysis Bullosa, Sci Transl Med 6:264-7.  


Atwood, SX., Tang, J, Chang, A., Li, M., and Oro, AE (2013), “Gli activation by aPKC regulates BCC growth” Nature 2013 494:484-8.

Aasi, S. Silkiss, R., Tang, JY, Wysong, A. Liu, A. Epstein, E. Oro, AE, Chang AL (2013) New onset keratoacanthomas after vismodegib treatment fro locally advanced basal cell carcinoma: a report of 2 cases. JAMA Dermatol 149:242-3.

Woo WM, Atwood SX, Zhen HH, Oro AE (2013) Rapid Genetic Analysis of epithelial-mesenchymal signaling during hair regeneration. J Vis Exp Feb 28: (72) e4344.

Danial C, Lingala B, Balise R, Oro AE, Reddy S, Colevas A, Chang AL (2013) Markedly improved overall survival in 10 consecutive metastatic basal cell carcinoma patients.  Br J Dermatol, March 23, epub.

Xiao Y, Woo WM, Nagao K, Li W, Terunuma A, Mukouyama YS, Oro AE, Vogel JC, Brownell I. (2013) Perivascular hair follicle stem cells associate with a venule annulus J Invest Dermatol  133:2324-31.

Atwood, SX, Whitson RJ, Oro, AE (2013) “Patch”ing up our tumor signaling knowledge J Invest Derm 133:1131-3.

Chang AL, Atwood SX, Tartar DM, Oro AE (2013)  Surgical excision after neoadjuvant therapy with vismodegib for a locally advanced basal cell carcinoma and resistant basal cell carcinoma in Gorlin Syndrome JAMA Dermatol 149:639-41.

Yucel, G, Altindag, B. Gomez-ospina, N. Rana, A. Panagiotakos, G., Lara, MF, Dolmetsch, R and Oro, AE (2013) State-dependent signaling by Cav1.2 regulates hair follicle stem cell function, Genes Dev. 27: 1217-22

Whyte, JL, Smith AA, Liu B., Manzano WR, Evans, ND, Dhamdhere GR, Fang, MY, Chang, HY, Oro, AE, and Helms, JA (2013)  Augmenting endogenous Wnt signaling improves skin wound healing PLoS One 8:e76883

Yucel, G. Arnam, J. Case-Means P. Huntzicker, E. Lara, M. Yuan J. Kuo C. and Oro, AE  (2014) Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing B-catenin, Stem Cells 32:85-92 


Gomez-Ospina N, Chang A, Qu K, Oro AE. (2012) A Sonic Hedgehog Locus Translocation associated with Basal Cell Carcinomas. N Engl J Med 366, 2233-4

Sekulic A, Migden, MR, Oro, AE, Dirix L, Lewis KD, Hainsworth JD, Solomon JA, Yoo S, Arron ST, Friedlander PA, Marmur E, Rudin CM, Chang ALS, Low JA, Mackey HM, Yauch RL, Graham RA, Reddy JC, Hauschild A. (2012)  Efficacy and Safety of Vismodegib in Advanced Basal Cell Carcinoma. N Engl J Med 366:2171-9

Woo W-M, Zhen HH, Oro AE. (2012) Shh maintains dermal papilla identity and hair morphogenesis via a Noggin – Shh regulator loop. Genes and Dev 26: 1235-46

Atwood, SX, Chang, ALS, and Oro, AE (2012) Hedgehog pathway inhibition and the race against tumor evolution J Cell Biol 199:193-7

Chang, ALS and Oro, AE (2012) Initial Assessment of tumor regrowth after vismodegib in advanced Basal cell carcinoma Arch Dermatol 148:1324-5.

Oro, AE and Tang, JY (2012). Basal Cell Nevus Syndrome. In:  Fitzpatrick’s Dermatology in General Medicine, 8th Edition. The McGraw-Hill Companies, Inc. Publisher.


Ra H, Piyawattanametha W, González-Gonzalez E, Mandella MJ, Kino GS, Solgaard O, Leake D, Kaspar R, Oro AE, Contag CH. (2011). In vivo imaging of human and mouse skin with a handheld dual-axis confocal fluorescence microscope, J Invest Dermatol. 13, 1061-6.

Yucel G, and Oro, AE. (2011). Cell Migration:GSK3ß steers the cytoskeleton’s tip, Cell  144, 319-21.

Woo WM, Oro AE. (2011). SnapShot: hair follicle stem cells. Cell. 146, 334-334.e2.

Hillman RT, Feng BY, Ni J, Woo W-M, Milenkovic L, Hayden Gephart MG, Teruel MN, Oro AE, Chen JK, Scott MP. (2011). Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev. 25, 2333-46. 


Quinones GA, Jin J, Oro AE. (2010). I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. J Cell Biol. 189, 353-67.

Quinones GA, Oro AE. (2010). BAR domain competition during directional cellular migration. Cell Cycle. 9,  Epub Jul 19;9(13).

Bershteyn M, Atwood SX, Woo W-M, Li M, Oro AE. (2010). MIM and cortactin antagonism regulates ciliogenesis and Hedgehog signaling. Dev Cell. 19, 270-283.

DeRouen MC, Zhen H, Tan SH, Williams S, Marinkovich MP, Oro AE. (2010).  Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol. 10:112-5.


Gonzalez-Quevedo, R., Shoffer, M., Horng, L., and Oro A. E., (2005). Receptor tyrosine phosphatase-dependent Cytoskeletal remodeling by the hedgehog-responsive gene MIM / BEG4 J Cell Biol 168, 453-463.

Sarin, KY, Cheung, P, Gillison, D, Lee, E, Tennen, RI, Wang, E, Artandi, MK, Oro AE, and Artandi, SE (2005). Conditional telomerase induction causes proliferation of hair follicle stem cells.  Nature 436, 1048-52.

Huntzicker E.G., Estay I, Zhen H., Lokteva L.A., Jackson P. K., Oro A.E., (2005). Dual degradation signals control Gli stability and tumor formation Genes Dev 20, 276-81.

Oro, A.E. (2005). Spatial and temporal regulation of hair follicle progenitors by hedgehog signaling. In:  Hedgehog-Gli Signaling and Human Disease. Ariel Ruiz I Altaba, editor. Kluwer Academic / Plenum Publishers, Landes Bioscience.

Oro AE (2006). Mammalian Variations on a Theme: a Smo and Sufu Surprise: Dev Cell 10:156.

Sneddon, J.B., Zhen, H.H., Montgomery, K., van de Rijn, M., Tward, A.D., West, R., Gladstone, H., Chang, H., Morganroth, G.S., Oro, AE., Brown. P.O. (2006).  BMP Antagonist Gremlin 1 is Widely Expressed by Cancer-associated Stromal Cells and Can Promote Tumor Cell Proliferation. Proc Natl Acad Sci 103, 14842-7.

Oro AE., (2007). The Primary cilia, a ‘Rab-id’ transit system for hedgehog signaling. Current Opinion in Cell Biology 19, 1-6.

Huntzicker E.G., Oro, AE., (2008).  Controlling Hair Follicle Signaling Pathways through Polyubiquitination.  J Invest Dermatol. 128, 1081-7.

Oro, AE. (2008).  A new role for an old friend: NFAT and stem cell quiescence. Cell Stem Cell 2, 104-6.

Gao, J, DeRouen, M., Chen, C-H., Nguyen, M, Nguyen, N.T., Ido, H., Harada, K., Sekiguchi, K., Morgan, B.A., Miner, J., Oro, A.E. and Marinkovich, M.P. (2008).  Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev 22, 2111-24.

Oro, AE. (2008). Basal Cell Nevus Syndrome. In:  Fitzpatrick’s Dermatology in General Medicine, 7th Edition. The McGraw-Hill Companies, Inc. Publisher.

DeRouen MC, Oro AE. (2009). The primary cilium: a small yet mighty organelle. J Invest Dermatol. 129, 264-5. Review.


Callahan, C.A. and Oro, A.E., (2001). Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling.  Curr Opin Genet Dev, 11:541-6.

Oro, A.E., Higgins, K, (2003). Hair cycle regulation of Hedgehog signal reception, Dev Bio 253, 23-44.

Chang, HY, Ridky, TW, Kimball, AB, Hughes, E, and Oro AE, (2003). Eruptive xanthomas associated with olanzapine use, Arch Dermatol, Aug;139(8):1045-8.

Gotlib J, Kohler S, Reicherter P, Oro AE, Zehnder JL. (2003). Heterozygous prothrombin G20210A gene mutation in a patient with livedoid vasculitis. Arch Dermatol, 139, 1081-3.

Callahan, C.A., Ofstad, T., Horng  L., Wang J.K., Zhen H.H., Coulombe P.A., and Oro A.E. (2004). BEG4 / MTSS1, a Sonic hedgehog target gene that potentiates Gli transcription Genes Dev.18, 2724-9.


Oro, A.E., Higgins, K.M., Hu, Z., Bonifas, J.M., Epstein, E.H., and Scott, M.P. (1997). Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog.  Science 276, 817-821. 

Fan, H., Oro, A.E., Scott, M.P., and Khavari, P. A., (1997). Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog.  Nature Med 3, 788-792. 

Oro, A.E. and Scott, M.P. (1998). Splitting Hairs: Dissecting Roles of Signaling Systems in Epidermal Development, Cell 95, 575-578.

Azsterbaum, M, Epstein, J., Oro, A., Douglas, V., LeBoit, P.E., Scott, M.P., and Epstein, E.H. (1999). Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice,  Nature Med 5, 1285-1291.


Oro, A.E., McKeown, M., and Evans, R.M.(1990).  Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoic acid responsive transcription factor, the Retinoid X receptor.  Nature 347, 298-301.

Mangelsdorf, D.J., Borgmeyer, U., Heyman, R.A., Zhou, J., Ong, E.S., Oro, A.E., Kakizuka, A., and Evans, R.M. (1992). Characterization of the three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 6,  329-344.

Oro, A.E., McKeown, M. and Evans, R.M. (1992). The Drosophila Retinoid X receptor homolog ultraspiracle functions in both female reproduction and eye morphogenesis. Development 115, 449-462.

Yao, Tso-Pang, Segraves, W.A., Oro, A.E., McKeown, M., and Evans, R.M.(1992). Transactivation by the ecdysone receptor requires the conserved heterodimerization function of ultraspiracle. Cell 71,  63-72.

Oro, A.E., McKeown, M., and Evans, R.M. (1992). The Drosophila nuclear receptors: new insight into the actions of nuclear receptors in development.  Curr Op Genet Dev 2, 269-274.


Oro, A.E. and Walbot, V. (1984). Speculations about Lack of Variation in B37N Mitochondrial DNA.  Maize Cooperative Newsletter 58, 187.

Oro, A.E., Newton, K.J., and Walbot, V. (1984). Lack of Variation in B37N Mitochondrial DNA in Maize.  Maize Cooperative Newsletter 58, 186.

Oro, A.E., Newton, K.J., and Walbot, V. (1985).  Molecular Analysis of the Inheritance and Stability of the Mitochondrial Genome of an Inbred Line of Maize. Theoretical and Applied Genetics 70, 287-293.

Hollenberg, S.M., Weinberger, C., Ong, E.S., Cerelli, G., Oro, A., Lebo, R., Thompson, E.B., Rosenfeld, M.G., and Evans R.M.(1985).  Primary Structure and Expression of a Functional Human Glucocorticoid Receptor cDNA. Nature 318, 635-641.

Oro, A.E., Simerly, R.B., and Swanson, L.W.(1988). Estrous Cycle Variations in Levels of CCK Immunoreactivity within cells of Three Interconnected Sexually Dimorphic Forebrain Nuclei.  Neuroendocrinology 47, 225-235.

Oro, A.E., Hollenberg, S.M., and Evans R.M.(1988).  Transcriptional Inhibition by a Glucocorticoid receptor-ß-galactosidase Fusion protein. Cell 55, 1109-1114.

Oro, A.E., Ong, E.S., Margolis, J.S., Posakony, J.W., McKeown, M., and Evans, R.M.(1988). The Drosophila gene knirps-related is a member of the steroid receptor gene superfamily.  Nature 336, 493-496.

Hong, F.D., Huang, H.J., To, H., Young, L.J., Oro, A.,  Bookstein, R., Lee, E.Y., and Lee, W.H.(1989).  Structure of the Human Retinoblastoma Gene.  Proc Natl Acad Sci USA 86, 5502-5506.

Oro, A.E., Umesono, K., and Evans R.M. (1989). Steroid Hormone Receptor Homologs in Development. Development 107 (Suppl.), 133-140.