Oro Laboratory Publications

2018

Whitson RJ, Lee A, Urman NM, Mirza A, Yao CY, Brown AS, Li JR, Shankar G, Fry MA, Atwood SX, Lee EY, Hollmig ST, Aasi SZ, Sarin KY, Scott MP, Epstein EH Jr, Tang JY, Oro AE.(2018) Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas. Nat Med. 2018 Mar;24(3):271-281

Kuonen F, Surbeck I, Sarin KY, Dontenwill M, Rüegg C, Gilliet M, Oro AE, Gaide O (2018) TGFB, Fibronectin, and Integrin a5B1 Promote Invasion in Basal cell carcinoma J Invest Dermatol. Jul 14. pii: S0022-202X(18)31966-3

Cho HG, Kuo KY, Li S, Bailey I, Aasi S, Chang ALS, Oro AE, Tang JY, Sarin KY (2018) Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility JCI Insight. 2018 Aug 9;3(15). pii: 122744. doi: 10.1172/jci.insight.122744. See commentaries in Stanford Medicine and national news. 

Drummond ML, Li M, Tarapore E, Nguyen TTL, Barouni BJ, Cruz S, Tan KC, Oro AE, Atwood SX (2018) Actin Polymerization controls cilia-mediated signaling J Cell Biol. Sep 3;217(9):3255-3266

Pattison, JM, Melo, SP, Piekos SN, Torkelson JL, Bashkirova, E, Mumbach, MR, Rajasingh, C. Zhen, HH, Li, L, Liaw, EJ, Alber, D, Rubin, AJ, Shankar, G, Bao, X, Chang, HY, Khavari, PA, and Oro, AE (2018) Retinoic Acid and BMP4 Cooperate with TP63 to alter chromatin dynamics during Surface Epithelial Commitment Nature Genetics, in press  http://biorxiv.org/cgi/content/short/348839v1

Li, L, Wang, Y, Torkelson, JL, Pattison, JM, Zhen, HH, Duren, Z, Fang, F, Melo, SP, Piekos SN, Li, J, Liaw, EJ, Chen, L., Li, R., Wernig, M, Wong, WH,  Chang, HY, and Oro, AE (2018) Feedback Regulation between Initiation and Maturation Networks Orchestrates the Chromatin Dynamics of Epidermal Lineage Commitment, Cell Stem Cell, under review  http://biorxiv.org/cgi/content/short/349308v1

Mirza, AN, McKellar, SA, Urman, NM, Brown, AS, Hollmig, T., Aasi, SZ, and Oro AE (2018) LAP2 proteins Chaparone Gli1 movement between Lamina and Chromatin to regulate Transcription, Cell, in press.



2017

Whitson RJ, Oro AE (2017) Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior Cell Stem Cell. Feb 2;20(2):149-150

Mirza AN, Fry MA, Urman NM, Atwood SX, Roffey J, Ott GR, Chen B, Lee A, Brown AS, Aasi SZ, Hollmig T, Ator MA, Dorsey BD, Ruggeri BR, Zificsak CA, Sirota M, Tang JY, Butte A, Epstein E, Sarin KY, Oro AE (2017) Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. JCI Insight. 2017 Nov 2;2(21). pii: 97071. doi: 10.1172/jci.insight.97071

2016

Danial C, Sarin KY, Oro AE, Chang AL (2016) An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib. Clin Cancer Res. Mar 15;22(6):1325-9

Kwon GP, Ally MS, Bailey-Healy I, Oro AE, Kim J, Chang AL, Aasi S, Tang JY (2016)  Update to an open-label clinical trial of vismodegib as neoadjuvant before surgery for high-risk basal cell carcinoma  J Am Acad Dermatol. Jul;75(1):213-5

Wang K, Lee CS, Marinkovich MP, Chang HY, Oro AE, Khavari PA (2016) Factors that may promote an effective local research environment J Invest Dermatol.Aug;136(8):1529-31

Kennedy Crispin M, Ko JM, Craiglow BG, Li S, Shankar G, Urban JR, Chen JC, Cerise JE, Jabbari A, Winge MC, Marinkovich MP, Christiano AM, Oro AE, King BA (2016) Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI Insight. Sep 22;1(15):e89776

Urman NM, Mirza A, Atwood SX, Whitson RJ, Sarin KY, Tang JY, Oro AE (2016) Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions PLoS OneDec 28;11(12):e0168031

2015

Atwood, SX, Sarin, KY, Whitson,RJ, Li, JR, Kim, G, Rezaee, M., Ally, MS, Kim, J, Yao, CY, Chang, ALS*, Oro, AE*, and Tang, JY* (2015) Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma. Cancer Cell 27:342-353  * co-senior authors. See also accompanying Preview by Ridky and Cotsarelis. 

Atwood, SX, Sarin KY, Li, JR, Yao, CY, Urman, NM, Chang, ALS, Tang, JY, and Oro AE (2015) Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug Resistant Basal Cell Carcinomas, J Invest Dermatol  doi:10.1038/jid.2015.115

Zhao X, Ponomaryov T, Ornell KJ, Zhou P, Dabral SK, Pak E, Li W, Atwood SX, Whitson RJ, Chang AL, Li J, Oro AE, Chan JA, Kelleher JF, Segal RA (2015)  RAS/MAPK Activation Drives Resistance to SMO Inhibition Metastasis and Tumor Evolution in Shh-Dependent Tumors Cancer Res. Sep 1;75(17):3623-35

Jaju PD, Nguyen CB, Mah AM, Atwood SX, Li J, Zia A, Chang ALS, Oro AE, Tang JY, Lee CS, Sarin KY (2015) Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma. J Invest Dermatol. Dec;135(12):3197-3200

2014

Melo, S. Lisowski, L. Bashkirova, E. Zhen H. Chu K. Keene, D. Marinkovich, P. Kay, M. Oro, AE (2014) Somatic scarless correction of junctional epidermolysis bullosa by a highly recombinogenic AAV virus. Mol Therapy 22:725-33

Atwood, SX and Oro, AE (2014) “Atypical” Regulation of Hedgehog-dependent cancers Cancer Cell 25:133-4

Tang, Y. Schubert, S. Bandopadhaay, P. Bergthold, G. Nguyen, B. Masoud, S. Vue, N. Balansay B. , Yu, F., Oh, S., Chen, S. Ponnuswami, A. Monje-Diesseroth, M., Atwood, SX, Whitson RJ, Lee, A, Tang, JY, Qi, J, Beroukhim, R., Wechsler-Reya, R., Oro, AE, Bradner, JE, and Cho, YJ,  (2014)  Epigenetic Regulation of Hedgehog Pathway transcriptional output by BRD4  Nature Med 20:732-40.

Oro, AE and Watt, FM. (2014), editors. The Skin and Its DiseasesCold Spring Harbor Perspectives in Medicine CSH Press: New York.

Atwood, SX, Whitson, R., and Oro AE (2014) Advanced Basal Cell Carcinoma Therapy, in Cold Spring Harbor Perspectives in Medicine Oro AE and Watt, FM, eds.  CSH Press: New York.

Sebastiano, V, Zhen HH, Derafshi, BH, Bashkirova, L, Melo, S, Wang, P, Leung, T, Siprashvili, Tichy, A., Li,J, Ameen M., Hawkins, J., Lee, S., Li, L, Bauer, G., Lisowski, Kay, M., Kim, SK, Lane, AT, Wernig, M. and Oro, AE (2014) Corrected Induced Pleuripotent Stem Cell Based Therapy for the Treatment of Recessive Dystrophic Epidermolysis Bullosa, Sci Transl Med 6:264-7.  

2013

Atwood, SX., Tang, J, Chang, A., Li, M., and Oro, AE (2013), “Gli activation by aPKC regulates BCC growth” Nature 2013 494:484-8.

Aasi, S. Silkiss, R., Tang, JY, Wysong, A. Liu, A. Epstein, E. Oro, AE, Chang AL (2013) New onset keratoacanthomas after vismodegib treatment fro locally advanced basal cell carcinoma: a report of 2 cases. JAMA Dermatol 149:242-3.

Woo WM, Atwood SX, Zhen HH, Oro AE (2013) Rapid Genetic Analysis of epithelial-mesenchymal signaling during hair regeneration. J Vis Exp Feb 28: (72) e4344.

Danial C, Lingala B, Balise R, Oro AE, Reddy S, Colevas A, Chang AL (2013) Markedly improved overall survival in 10 consecutive metastatic basal cell carcinoma patients.  Br J Dermatol, March 23, epub.

Xiao Y, Woo WM, Nagao K, Li W, Terunuma A, Mukouyama YS, Oro AE, Vogel JC, Brownell I. (2013) Perivascular hair follicle stem cells associate with a venule annulus J Invest Dermatol  133:2324-31.

Atwood, SX, Whitson RJ, Oro, AE (2013) “Patch”ing up our tumor signaling knowledge J Invest Derm 133:1131-3.

Chang AL, Atwood SX, Tartar DM, Oro AE (2013)  Surgical excision after neoadjuvant therapy with vismodegib for a locally advanced basal cell carcinoma and resistant basal cell carcinoma in Gorlin Syndrome JAMA Dermatol 149:639-41.

Yucel, G, Altindag, B. Gomez-ospina, N. Rana, A. Panagiotakos, G., Lara, MF, Dolmetsch, R and Oro, AE (2013) State-dependent signaling by Cav1.2 regulates hair follicle stem cell function, Genes Dev. 27: 1217-22

Whyte, JL, Smith AA, Liu B., Manzano WR, Evans, ND, Dhamdhere GR, Fang, MY, Chang, HY, Oro, AE, and Helms, JA (2013)  Augmenting endogenous Wnt signaling improves skin wound healing PLoS One 8:e76883

Yucel, G. Arnam, J. Case-Means P. Huntzicker, E. Lara, M. Yuan J. Kuo C. and Oro, AE  (2014) Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing B-catenin, Stem Cells 32:85-92 

2012

Gomez-Ospina N, Chang A, Qu K, Oro AE. (2012) A Sonic Hedgehog Locus Translocation associated with Basal Cell Carcinomas. N Engl J Med 366, 2233-4

Sekulic A, Migden, MR, Oro, AE, Dirix L, Lewis KD, Hainsworth JD, Solomon JA, Yoo S, Arron ST, Friedlander PA, Marmur E, Rudin CM, Chang ALS, Low JA, Mackey HM, Yauch RL, Graham RA, Reddy JC, Hauschild A. (2012)  Efficacy and Safety of Vismodegib in Advanced Basal Cell Carcinoma. N Engl J Med 366:2171-9

Woo W-M, Zhen HH, Oro AE. (2012) Shh maintains dermal papilla identity and hair morphogenesis via a Noggin – Shh regulator loop. Genes and Dev 26: 1235-46

Atwood, SX, Chang, ALS, and Oro, AE (2012) Hedgehog pathway inhibition and the race against tumor evolution J Cell Biol 199:193-7

Chang, ALS and Oro, AE (2012) Initial Assessment of tumor regrowth after vismodegib in advanced Basal cell carcinoma Arch Dermatol 148:1324-5.

Oro, AE and Tang, JY (2012). Basal Cell Nevus Syndrome. In:  Fitzpatrick’s Dermatology in General Medicine, 8th Edition. The McGraw-Hill Companies, Inc. Publisher.

2011

Ra H, Piyawattanametha W, González-Gonzalez E, Mandella MJ, Kino GS, Solgaard O, Leake D, Kaspar R, Oro AE, Contag CH. (2011). In vivo imaging of human and mouse skin with a handheld dual-axis confocal fluorescence microscope, J Invest Dermatol. 13, 1061-6.

Yucel G, and Oro, AE. (2011). Cell Migration:GSK3ß steers the cytoskeleton’s tip, Cell  144, 319-21.

Woo WM, Oro AE. (2011). SnapShot: hair follicle stem cells. Cell. 146, 334-334.e2.

Hillman RT, Feng BY, Ni J, Woo W-M, Milenkovic L, Hayden Gephart MG, Teruel MN, Oro AE, Chen JK, Scott MP. (2011). Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev. 25, 2333-46. 

2010

Quinones GA, Jin J, Oro AE. (2010). I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. J Cell Biol. 189, 353-67.

Quinones GA, Oro AE. (2010). BAR domain competition during directional cellular migration. Cell Cycle. 9,  Epub Jul 19;9(13).

Bershteyn M, Atwood SX, Woo W-M, Li M, Oro AE. (2010). MIM and cortactin antagonism regulates ciliogenesis and Hedgehog signaling. Dev Cell. 19, 270-283.

DeRouen MC, Zhen H, Tan SH, Williams S, Marinkovich MP, Oro AE. (2010).  Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol. 10:112-5.

2005-2009

Gonzalez-Quevedo, R., Shoffer, M., Horng, L., and Oro A. E., (2005). Receptor tyrosine phosphatase-dependent Cytoskeletal remodeling by the hedgehog-responsive gene MIM / BEG4 J Cell Biol 168, 453-463.

Sarin, KY, Cheung, P, Gillison, D, Lee, E, Tennen, RI, Wang, E, Artandi, MK, Oro AE, and Artandi, SE (2005). Conditional telomerase induction causes proliferation of hair follicle stem cells.  Nature 436, 1048-52.

Huntzicker E.G., Estay I, Zhen H., Lokteva L.A., Jackson P. K., Oro A.E., (2005). Dual degradation signals control Gli stability and tumor formation Genes Dev 20, 276-81.

Oro, A.E. (2005). Spatial and temporal regulation of hair follicle progenitors by hedgehog signaling. In:  Hedgehog-Gli Signaling and Human Disease. Ariel Ruiz I Altaba, editor. Kluwer Academic / Plenum Publishers, Landes Bioscience.

Oro AE (2006). Mammalian Variations on a Theme: a Smo and Sufu Surprise: Dev Cell 10:156.

Sneddon, J.B., Zhen, H.H., Montgomery, K., van de Rijn, M., Tward, A.D., West, R., Gladstone, H., Chang, H., Morganroth, G.S., Oro, AE., Brown. P.O. (2006).  BMP Antagonist Gremlin 1 is Widely Expressed by Cancer-associated Stromal Cells and Can Promote Tumor Cell Proliferation. Proc Natl Acad Sci 103, 14842-7.

Oro AE., (2007). The Primary cilia, a ‘Rab-id’ transit system for hedgehog signaling. Current Opinion in Cell Biology 19, 1-6.

Huntzicker E.G., Oro, AE., (2008).  Controlling Hair Follicle Signaling Pathways through Polyubiquitination.  J Invest Dermatol. 128, 1081-7.

Oro, AE. (2008).  A new role for an old friend: NFAT and stem cell quiescence. Cell Stem Cell 2, 104-6.

Gao, J, DeRouen, M., Chen, C-H., Nguyen, M, Nguyen, N.T., Ido, H., Harada, K., Sekiguchi, K., Morgan, B.A., Miner, J., Oro, A.E. and Marinkovich, M.P. (2008).  Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev 22, 2111-24.

Oro, AE. (2008). Basal Cell Nevus Syndrome. In:  Fitzpatrick’s Dermatology in General Medicine, 7th Edition. The McGraw-Hill Companies, Inc. Publisher.

DeRouen MC, Oro AE. (2009). The primary cilium: a small yet mighty organelle. J Invest Dermatol. 129, 264-5. Review.

2000-2004

Callahan, C.A. and Oro, A.E., (2001). Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling.  Curr Opin Genet Dev, 11:541-6.

Oro, A.E., Higgins, K, (2003). Hair cycle regulation of Hedgehog signal reception, Dev Bio 253, 23-44.

Chang, HY, Ridky, TW, Kimball, AB, Hughes, E, and Oro AE, (2003). Eruptive xanthomas associated with olanzapine use, Arch Dermatol, Aug;139(8):1045-8.

Gotlib J, Kohler S, Reicherter P, Oro AE, Zehnder JL. (2003). Heterozygous prothrombin G20210A gene mutation in a patient with livedoid vasculitis. Arch Dermatol, 139, 1081-3.

Callahan, C.A., Ofstad, T., Horng  L., Wang J.K., Zhen H.H., Coulombe P.A., and Oro A.E. (2004). BEG4 / MTSS1, a Sonic hedgehog target gene that potentiates Gli transcription Genes Dev.18, 2724-9.

1996-1999

Oro, A.E., Higgins, K.M., Hu, Z., Bonifas, J.M., Epstein, E.H., and Scott, M.P. (1997). Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog.  Science 276, 817-821. 

Fan, H., Oro, A.E., Scott, M.P., and Khavari, P. A., (1997). Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog.  Nature Med 3, 788-792. 

Oro, A.E. and Scott, M.P. (1998). Splitting Hairs: Dissecting Roles of Signaling Systems in Epidermal Development, Cell 95, 575-578.

Azsterbaum, M, Epstein, J., Oro, A., Douglas, V., LeBoit, P.E., Scott, M.P., and Epstein, E.H. (1999). Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice,  Nature Med 5, 1285-1291.

1990-1995

Oro, A.E., McKeown, M., and Evans, R.M.(1990).  Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoic acid responsive transcription factor, the Retinoid X receptor.  Nature 347, 298-301.

Mangelsdorf, D.J., Borgmeyer, U., Heyman, R.A., Zhou, J., Ong, E.S., Oro, A.E., Kakizuka, A., and Evans, R.M. (1992). Characterization of the three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 6,  329-344.

Oro, A.E., McKeown, M. and Evans, R.M. (1992). The Drosophila Retinoid X receptor homolog ultraspiracle functions in both female reproduction and eye morphogenesis. Development 115, 449-462.

Yao, Tso-Pang, Segraves, W.A., Oro, A.E., McKeown, M., and Evans, R.M.(1992). Transactivation by the ecdysone receptor requires the conserved heterodimerization function of ultraspiracle. Cell 71,  63-72.

Oro, A.E., McKeown, M., and Evans, R.M. (1992). The Drosophila nuclear receptors: new insight into the actions of nuclear receptors in development.  Curr Op Genet Dev 2, 269-274.

1984-1989

Oro, A.E. and Walbot, V. (1984). Speculations about Lack of Variation in B37N Mitochondrial DNA.  Maize Cooperative Newsletter 58, 187.

Oro, A.E., Newton, K.J., and Walbot, V. (1984). Lack of Variation in B37N Mitochondrial DNA in Maize.  Maize Cooperative Newsletter 58, 186.

Oro, A.E., Newton, K.J., and Walbot, V. (1985).  Molecular Analysis of the Inheritance and Stability of the Mitochondrial Genome of an Inbred Line of Maize. Theoretical and Applied Genetics 70, 287-293.

Hollenberg, S.M., Weinberger, C., Ong, E.S., Cerelli, G., Oro, A., Lebo, R., Thompson, E.B., Rosenfeld, M.G., and Evans R.M.(1985).  Primary Structure and Expression of a Functional Human Glucocorticoid Receptor cDNA. Nature 318, 635-641.

Oro, A.E., Simerly, R.B., and Swanson, L.W.(1988). Estrous Cycle Variations in Levels of CCK Immunoreactivity within cells of Three Interconnected Sexually Dimorphic Forebrain Nuclei.  Neuroendocrinology 47, 225-235.

Oro, A.E., Hollenberg, S.M., and Evans R.M.(1988).  Transcriptional Inhibition by a Glucocorticoid receptor-ß-galactosidase Fusion protein. Cell 55, 1109-1114.

Oro, A.E., Ong, E.S., Margolis, J.S., Posakony, J.W., McKeown, M., and Evans, R.M.(1988). The Drosophila gene knirps-related is a member of the steroid receptor gene superfamily.  Nature 336, 493-496.

Hong, F.D., Huang, H.J., To, H., Young, L.J., Oro, A.,  Bookstein, R., Lee, E.Y., and Lee, W.H.(1989).  Structure of the Human Retinoblastoma Gene.  Proc Natl Acad Sci USA 86, 5502-5506.

Oro, A.E., Umesono, K., and Evans R.M. (1989). Steroid Hormone Receptor Homologs in Development. Development 107 (Suppl.), 133-140.