Research

OHNS Research Projects

Optical Imaging to Improve Surgery & Targeted Therapy in Brain Tumors (R01 pending review)

Improving Surgical Precision and Predicting Antibody delivery in Pancreatic Cancer (R01 pending review)

Dual-Modality Antibody Imaging for Precision Nodal Staging (R01 pending review)

Clinical Trial to Assess Benefit of Fluorescence-guided Head and Neck Cancer Surgery Phase II (submission in Feb 2019)

Phase I - II Study of Ad/PNP(IND14271,1/19/10)for HNSCC(OrphanDrugDes,14-4438,6/8/15) (1R01FD005746-01A1MPI Rosenthal) 

Prototype optical device for image guided surgery with panitumumab-IRDye800 (R01 5R01CA190306-05 PI Rosenthal)

Adaptation and validation of DIGEST for FEES

Development and investigation of mobile technology as an adjunct to traditional swallowing therapy

Assessing the knowledge of head and neck cancer awareness in subjects with HIV

Normative values for percentage water content in neck tissue of normal individuals without lymphedema

Use of the G8 geriatric screening tool to identify high risk head and neck cancer patients

Swallowing outcomes in patients undergoing robotic head and neck surgery

Vasu Divi, MD / Lily Lam, NP

Promoting Self- Efficacy Among Head and Neck Cancer Survivors

Identification of Unknown Primary Carcinoma in Patients with Head & Neck Cancer: A Retrospective Study Evaluating the Clinical Implications, Outcomes, and Toxicity of Transoral Robotic Surgery (TORS) in the Multidisciplinary Treatment of Head and Neck Cancer of Unknown Primary

Hyperspectral Imaging of the Head and Neck

Cost Comparison of Treatments for Selected Oropharyngeal Carcinomas: Frontline Surgery Versus Radiation and Chemotherapy

Measure, Mark and Cut: The Importance of Consistent Margin Management

Robotic Head and Neck Surgery

Identification and Characterization of Novel Proteins and Genes in Head and Neck and/or Skin Cancer (SQL 76537

Whole Blood Specimen Collection From Healthy Volunteers

A Study to Evaluate Immunological Response to PD-1 Inhibition in Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Clinical Outcomes in Patients Undergoing Surgical Management for Hashimoto's Thyroiditis

Thyroid Cancer Care Collaborative Registry Protocol

Ultrasound Applications in Head & Neck Surgery

Defining Recurrent Versus Persistent Disease in Well-Differentiated Thyroid Cancer and the Importance of Delivering Appropriate Therap

A Randomized Phase 2 Trial of Neoadjuvant and Adjuvant Therapy with the IRX-2 Regimen in Patients with Newly Diagnosed Stage II, III, or IVA Squamous Cell Carcinoma of the Oral Cavity.

Aspirin in Vestibular Schwannoma
Multicenter, prospective, randomized, placebo-controlled phase II clinical trial of aspirin for patients with vestibular schwannomas undergoing observation
PI: Robert Jackler
Contact: Ksenia Aaron, Homer Abaya

Post operative opioid use
Prospective survey of opioid use in post operative otologic surgery
PI: Nik Blevins
Contact: Jason Qian, Ong-Dee Woods, Jennifer Alyono

Cholesteatoma imaging
Intraoperative and ex vivo imaging of cholesteatoma
PI: Tulio Valdez
Contact: Tulio Valdez, Homer Abaya

Venous pulsatile tinnitus
Prospective randomized controlled trial of surgery vs masking device for venous pulsatile tinnitus (no anatomical defect)
PI: Peter Santa Maria
Contact: Peter Santa Maria, Homer Abaya

Cell culture of tissues from otology patients
Translational project that requires patient tympanic membranes, middle ear mucosa, middle ear effusion, and blood. Collection of tympanic membrane and round window from organ donors.
PI: Peter Santa Maria
Contact: Homer Abaya

Imaging of otology patients
Multispectral imaging during otologic surgery
PI: Yona Vaisbuch, Nik Blevins
Contact: Yona Vaisbuch

Resting Tympanometry
Obtaining resting tympanometry of patients with pulsatile tinnitus, superior canal dehiscence, conductive hearing loss
PI: Yona Vaisbuch
Contact: Yona Vaisbuch

Wide band tympanometry
Obtaining wide band tympanometry before and after middle ear surgery, ossicular chain reconstruction, superior canal dehiscence resurfacing or plugging
PI: Yona Vaisbuch
Contact: Yona Vaisbuch

Health literacy & hearing loss
Correlation between health literacy and hearing aid compliance using questionnaire
PI: Yona Vaisbuch, Matt Fitzgerald, Uchechukwu Megwalu
Contact: Yona Vaisbuch

Vestibular schwannoma propensity analysis
Comparing 3 arms of treatment: Microsurgery-Radiosurgery-Observation
PI: Yona Vaisbuch
Contact: Yona Vaisbuch

Inner ear aqueducts anatomy
MicroCT based volumetric measurements of the cochlear and vestibular aqueducts
PI: Yona Vaisbuch
Contact: Yona Vaisbuch

Surgical Press Ganey (PG) scores
Retrospective analysis of surgeons' vs internists' nonmodifiable factors on PG scores
PI: Jennifer Alyono
Contact: Brian Nuyen, Jennifer Alyon

Home vestibular monitor
Wearable device for monitoring at home vestibular attacks
PI: Kristen Steenerson, Peter Santa Maria
Contact: Kristen Steenerson, Peter Santa Maria

Drink bottle for ET opening
Children drinking bottle that opens the eustachian tubes (ET) to prevent otitis media. "Ear buddy"
PI: Peter Santa Maria
Contact: Peter Santa Maria

Middle ear surgery simulation
Laboratory based middle ear simulation for training of medical students and residents
PI: Yona Vaisbuch
Contact: Yona Vaisbuch, Jared Shenson

Temporal bone dissection guide
Creating a 3D temporal bone dissection manual and atlas
PI: Peter Santa Maria
Contact: Ksenia Aaron, Yona Vaisbuch

Balance status in cochlear implants (CI)
Obtain video head impulse test (vHIT) and DHI pre surgery, 1-month post, and 3-month post & questionnaires every visit
PI: Yona Vaisbuch, Kristen Steenerson
Contact: Yona Vaisbuch

Expanded CI indications
MedEl clinical trial to expand their indications for CI candidacy
PI: Matt Fitzgerald, Nik Blevins
Contact: Matt Fitzgerald, Nik Blevins

Speech in Noise
Obtain speech in noise (SIN) data to make SIN testing default measure of speech perception in audiograms
PI: Matt Fitzgerald
Contact: Matt Fitzgerald

Speech in Noise & VS
Subgroup for obtaining SIN speech perception as a sensitive screening for VS
PI: Matt Fitzgerald
Contact: Matt Fitzgerald

FFR classification
Objective measure of sound identification using frequency-following response (FFR)
PI: Matt Fitzgerald, Nik Blevins
Contact: Matt Fitzgerald, Nik Blevins

Infant FFR
Normative values for infant FFR, and relationship to hyperbilirubinemia
PI: Matt Fitzgerald
Contact: Matt Fitzgerald

Perceptual learning
Patterns of learning with CI recipients and how they differ from normal hearing
PI: Matt Fitzgerald
Contact: Matt Fitzgerald

SSCD and OSA
Radiographic retrospective cohort study, superior semicircular canal dehiscence (SSCD) in obstructive sleep apnea (OSA) vs normal
PI: Jennifer Alyono
Contact: Jennifer Alyono, Yohan Song, Noor Ali, Ali Kouh

Moyamoya & hearing
Retrospective chart review to assess for correlation of hearing loss in moyamoya patients and to determine if degree of hearing recovery after revascularization
PI: Jennifer Alyono
Contact: Zahra Sayyid, Taha Jan

Pressure equalizing tube (PET) effectiveness for pediatric recurrent acute otitis media (rAOM)
Claims database analysis of PETs in children with rAOM
PI: Jennifer Alyono
Contact: Jason Qian, Jennifer Alyono

Resident feedback
Mixed methods study of feedback in resident education
PI: Jennifer Alyono
Contact: Erika Shimahara, Jared Shensen, Jennifer Alyono

DVT in otology/neurotology
Retrospective chart review of incidence of deep vein thrombosis in otology/neurotology patients
PI: Jennifer Alyono, Nik Blevins
Contact: Yohan Song, Jennifer Alyono

Otosclerosis and pregnancy
Claims database analysis of stapes surgery, effect of number of children in women vs men
PI: Jennifer Alyono
Contact: Jason Qian

Temporal bone pneumatization & dehiscence
CT based study examining the relations between degree of pneumatization and dehiscence (vessels, tegmen, superior canal)
PI: Yona Vaisbuch
Contact: Yona Vaisbuch

Vessel resurfacing literature review
Comparing outcomes of different materials for resurfacing: autologous vs artificial,  hard vs soft
PI: Yona Vaisbuch
Contact: Yona Vaisbuch

Balance trainer incorporated into hearing aids
Collaboration for Stanford-Rambam innovation center
PI: Yona Vaisbuch, Kristen Steenerson
Contact: Yona Vaisbuch

Stanford Inner Ear Organ Donor Program (SIODP)
Harvesting inner ear tissues from organ donors for basic and translational science projects
PI: Yona Vaiscbuch, Alan Cheng
Contact: Davood Hosseini, Yona Vaisbuch

Stereotactic radiotherapy outcomes in VS
Matched case control of observation vs stereotactic radiotherapy in vestibular schwannoma
PI: Peter Santa Maria
Contact: Pedrom Sioshansi

Natural history of cystic VS
Radiographic/chart review of natural history of cystic VS
PI: Jennifer Alyono
Contact: Zahra Sayyid, Yohan Song, Noor Ali, Taha Jan

Trends in CI in elderly
Claims database analysis of CI in elderly patients
PI: Jennifer Alyono
Contact: Yohan Song