Research Projects

Edward C. and Amy H. Sewall Professor
  • Decibel Therapeutics
  • Modulation of the Wnt pathway to restore inner ear function
  • Randomized Controlled Trial of Valganciclovir for Asymptomatic Cytomegaloirus Infected Hearing Impaired Infants
  • Mouse vestibular regeneration and function
  • Clinician-scientist training program in otolaryngology
  • Designing new aminoglycosides to alleviate inner ear toxicity (co-PI with Dr. Ricci)
  • Pathways towards regenerating the mammalian cochlea
  • Mechanisms of radial patterning during cochlear development (R01 with University of Nebraska; pending NIH review)
Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor, by courtesy, of Molecular and Cellular Physiology
  • Materials and Methods for Sustained Delivery of Drugs and Genes to the Cochlea (co-PI with Prof. Appel, Materials Science and Engineering)
  • What are we stimulating with transcranial ultrasound in Mice? (co-I; Dr. Kim Pauly's project, Radiology)
  • Mouse vestibular regeneration and function (co-I; Dr. Cheng's project)
  • Function of LOXHD1 in mechanosensory hair cells (co-I; Dr. Grillet's project)
  • Determinants of age-induced hearing loss and reversal strategies
  • Designing new aminoglycosides to alleviate inner ear toxicity
  • Synaptic Specializations in Auditory Hair Cells
  • Molecules and Mechanisms of Mammalian Hair Cell Mechanotransduction
  • The functional relevance and underlying molecular contributors to mammalian cochlear hair bundle viscoelasticity (R01 pending NIH review)
Professor of Otolaryngology - Head and Neck Surgery at the Stanford University Medical Center
  • Validation of Cancer Prevention and Control Using Smartphones, Cognitive Computing & Family Social Support
  • A Prospective, Multicenter Investigation of the da Vinci® SP™ Surgical System in TORS Procedures for Resection of Malignant Tumors
Professor of Otolaryngology-Head and Neck Surgery and of Radiology (Molecular Imaging Program at Stanford)
  • Dual orthogonal fluorescent protease sensors for image guided surgery (co-I; Dr. Matthew Bogyo's project, Pathology)
  • Next Generation Sentinel Node Mapping
  • Optical Imaging to Improve Surgery & Targeted Therapy in Brain Tumors
  • Phase II Study of Ad/PNP(IND14271,1/19/10)for HNSCC(OrphanDrugDes,14-4438,6/8/15)
  • Prototype optical device for image guided surgery with panitumumab-IRDye800
  • Fluorescence lifetime-based surgical specimen margin assessment for liver cancers (R01 with Massachusetts General Hospital; pending NIH review)
  • Real-time identification of the Sentinel Margin in Head and Neck Cancer (R01 pending NIH review)
  • Intraoperative Wide-field Fluorescent Imaging Guided Line-Scan 3D Confocal Fluorescent Microscopy for Precise Tumor Resection (R01 with Michigan State University; pending NIH review)
  • Time domain fluorescence imaging for surgical specimen margin assessment in head and neck cancers (R01 with Massachusetts General Hospital; pending NIH review)
  • In-human molecular imaging of therapeutic antibody delivery in PDAC (pending Pancreatic Cancer Action Network review)
  • Fluorescence-lifetime based surgical specimen margin assessment device (R01 with Massachusetts General Hospital; pending NIH review)
  • Magnetic Nanoparticles for Precision Surgical Oncology and Radiotherapy (pending Australian Government review)
  • Window trial to assess impact of atezolizumab delivery on pathological response (R01 pending NIH review)
  • Sentinel lymph node mapping for solid tumors with systemic delivery of labeled antibody (pending American Cancer Society review)
  • Reduction of Tumor-Positive Margins in Oncology Surgery (R01 with University of Alabama Birmingham; pending NIH review)
Professor of Otolaryngology - Head and Neck Surgery (Laryngology) and, by courtesy, of Anesthesiology, Perioperative & Pain Medicine at the Stanford University Medical Center
  • Biological and clinical evaluation of the laryngeal mucus layer
Assistant Professor of Otolaryngology/Head and Neck Surgery (Laryngology) at the Stanford University Medical Center and, by courtesy, of Music
  • Biological and clinical evaluation of the laryngeal mucus layer
  • Development of Model Systems to Investigate the Laryngeal Health Effects of Electronic Nicotine Delivery Systems (ENDS)
Clinical Associate Professor, Otolaryngology (Head and Neck Surgery)
  • Validation of Cancer Prevention and Control Using Smartphones, Cognitive Computing & Family Social Support (co-I; Dr. Holsinger's project)
  • Adaptation and Validation of the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) for Fiberoptic Endoscopic Evaluation of Swallowing (FEES)
Associate Professor of Otolaryngology - Head & Neck Surgery (Rhinology) and, by courtesy, of Neurosurgery at the Stanford University Medical Center
  • Development of a Rapidly-acting Preventive Therapy for Influenza (co-I; Dr. David Lewis' project, Pediatrics)
  • Influenza responses and repertoire in vaccination, infection and tonsil organoids (co-I; Dr. Mark Davis' project, Institute for Immunity, Transplantation, and Infection)
Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor, by courtesy, of Dermatology
  • Characterization of Neoantigens in Virus-Related Malignancies
  • Characterizing head and neck tumor neoantigensand T cells: looking beyond the usual suspects
  • A Pilot study to evaluate immunological response to PD-1 inhibition in squamous cell carcinoma of the head and neck (SCCHN) (Dr. Dimitrios Colevas' project, Med/Oncology)
  • Modeling the Role of Lymph Node Metastases in Tumor-Mediated Immunosuppression
  • The Parker Institute for Cancer Immunotherapy at Stanford School of Medicine (co-PI with Dr. Crystal Mackall, Pediatrics)
  • Reprogramming the Tumor-Immune Interface in Oral Cancer (pending NIH review)
  • Computational analysis of inflammatory oral cancer (IOC) using publicly available data: mechanisms of treatment response (co-I under Dr. Olivier Gevaert; pending NIH review)
  • Radionuclide imaging of microphysiological tumor systems (pending NIH review)
  • Simultaneous imaging of tumor metabolism and immune responses using PET (pending NIH review)
Assistant Professor of Otolaryngology (Facial Plastic and Reconstructive Surgery) at the Stanford University Medical Center
  • Mechanisms of Regeneration: Facial Nerve Injury and Repair
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Assistant Professor of Otolaryngology/Head and Neck Surgery (Otology and Neurotology) at the Stanford University Medical Center
  • Expanded Indications in the Adult Cochlear Implant Population
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Professor of Otolaryngology - Head and Neck Surgery at the Stanford University Medical Center, Emeritus
  • Phase II Study of Ad/PNP(IND14271,1/19/10)for HNSCC(OrphanDrugDes,14-4438,6/8/15) (co-I; Dr. Rosenthal's project)
  • Phase II Study of Ad/PNP(IND14271,1/19/10)for HNSCC(OrphanDrugDes,14-4438,6/8/15) (co-I; Dr. Rosenthal's project)
  • A Randomized Phase 2 Trial of Neoadjuvant and Adjuvant Therapy with the IRX-2 Regimen in Patients with Newly Diagnosed Stage III or IVA Squamous Cell Carcinoma of the Oral Cavity
Assistant Professor of Otolaryngology - Head and Neck Surgery
  • Function of LOXHD1 in mechanosensory hair cells
  • Pathways towards regenerating the mammalian cochlea (co-I; Dr. Cheng's project)
  • Molecules and Mechanisms of Mammalian Hair Cell Mechanotransduction (co-I; Dr. Ricci's project)
  • High-resolution localization of the hair cell mechanotransduction channel components by immunogold-scanning electronic microscopy (R21 pending NIH review)
Professor of Otolaryngology - Head and Neck Surgery (Rhinology) and, by courtesy, of Neurosurgery at the Stanford University Medical Center
  • A Phase 2 Multicenter, Double-blind, Randomized, Placebo-Controlled Trial to Evaluate Oral Ifetroban in Subjects with Symptomatic Aspirin Exacerbated Respiratory Disease (AERD)
Assistant Professor of Otolaryngology-HNS (Otology and Neurotology) at the Stanford University Medical Center
  • The Wearable ENG: A Dizzy Attack Event Monitor
  • Targeting Drug Delivery for Chronic Rhinosinusitis
  • EarBuddy: A non-invasive treatment for otitis media with effusion
  • Development of Antibiotic Adjuvants for the Treatment of Chronic Suppurative Otitis Media
  • Biomimetic peptoid antimicrobials to treat Chronic Suppurative Otitis Media (pending NIH review)
  • Investigating sensory hearing loss in Chronic Suppurative Otitis Media using a novel animal model (pending NIH review)
  • Investigating Sensory Hearing Loss in Chronic Suppurative Otitis Media Using a Novel Animal Model (pending Hearing Health Foundation review)
  • Nanoparticle adjuvant for Chronic Pseudomonal Infections in Cystic Fibrosis (pending Cystic Fibrosis Foundation review)
  • Development of Nanoparticle Antibiotic Adjuvant for the Treatment of Chronic Suppurative Otitis Media (pending Action on Hearing Loss review)
  • Nanoparticle adjuvant for Chronic Pseudomonal Infections in Cystic Fibrosis (pending NIH review)
  • A Dizzy Attack Event Monitor for Meniere's Disease: The Wearable ENG (pending Cures Within Reach review)
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Edward C. and Amy H. Sewall Professor in Otorhinolaryngology and Professor, by courtesy, of Neurosurgery and of Surgery
  • PROSPECTIVE, RANDOMIZED, PLACEBO-CONTROLLED PHASE II TRIAL OF ASPIRIN FOR VESTIBULAR SCHWANNOMAS
Associate Professor of Otolaryngology-Head and Neck Surgery (Sleep Surgery) at the Stanford University Medical Center
  • Influenza responses and repertoire in vaccination, infection and tonsil organoids (co-I; Dr. Mark Davis' project, Institute for Immunity, Transplantation, and Infection)
Edward C. and Amy H. Sewall Professor in the School of Medicine
  • Detection of transcriptome changes in single cells after aminoglycoside-induced hair cell loss in the chicken basilar papilla
  • Mouse vestibular regeneration and function (co-I; Dr. Cheng's project)
  • Genetic Regulation of Cochlear Development
  • Response of cochlear hair cells to pathological changes in the auditory system
  • Synaptic Specializations in Auditory Hair Cells (co-I; Dr. Ricci's project)
Professor of Otolaryngology
  • Characterization of the Mechanotransduction complex in hair cells
  • Molecular analysis of Tmie in sensory hair cells
Associate Professor of Otolaryngology - Head and Neck Surgery at the Stanford University Medical Center
  • TOGETHER: Track Outcomes & Guidance, Enabled Techonology for Health & Effective Resources
  • Prototype optical device for image guided surgery with panitumumab-IRDye800 (co-I; Dr. Rosenthal's project)
Associate Professor of Otolaryngology/Head and Neck Surgery (Rhinology) and, by courtesy, of Neurosurgery at the Stanford University Medical Center
  • A 24-Week Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group, Multicenter Study Evaluating the Efficacy and Safety of Intranasal Administration of 186 and 372 μg of OPN-375 Twice a Day (BID) in Subjects with Chronic Sinusitis Without the Presence of Nasal Polyps