Publications - Stefan Heller
Li, H., Corrales, C.E., Wang, Z., Zhao, Y., Wang, Y., Liu, H., and Heller, S. (2005). BMP4 signaling is involved in the generation of inner ear sensory epithelia. BMC Developmental Biology. 5:16 Open Access
Mutai, H., Mann, S., and Heller, S. (2005). Identification of chicken transmembrane channel-like (TMC) genes: Expression analysis in the cochlea. Neurosci. 132, 1115-1120. Pubmed
Li, H., Liu, H., Sage, C., Huang, M., Chen, Z.-Y., and Heller, S. (2004). Islet-1 expression in the developing chicken inner ear. J. Comp. Neurol. 477, 1-10. Pubmed
Keresztes, G., Martemyanov, K.A., Krispel, C.M., Mutai, H., Yoo, P.J., Maison, S.F., Burns, M.E., Arshavsky, V.Y., and Heller, S. (2004). Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. J. Biol. Chem. 279, 1581-1584. Pubmed
Li, H., Liu, H., Balt, S., Mann, S., Corrales, C.E., and Heller, S. (2004). Correlation of expression of the actin filament-bundling protein espin with stereocilia formation in the developing inner ear. J. Comp. Neurol. 468, 125-134. Pubmed
Li, H., Liu, H., Corrales, C.E., Mutai, H., and Heller, S. (2004). Correlation of Pax-2 expression with cell proliferation in the developing chicken inner ear. J. Neurobiol. 60, 61-70. Pubmed
Li, H., Roblin, G., Liu, H., and Heller, S. (2003). Generation of hair cells by directed differentiation of embryonic stem cells. Proc. Natl. Acad. Sci. USA 100, 13495-13500. Pubmed
Martemyanov, K.A., Lishko, P.V., Calero, N., Keresztes, G., Sokolov, M., Strissel, K.J., Leskov, I.B., Hopp, J., Kolesnikov, A.V., Chen, C. K., Lem, J., Heller, S., Burns, M.E., and Arshavsky, V.Y. (2003). The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. J Neuroscience 23, 10175-10181. Pubmed
Keresztes, G., Hibino, H., Hudspeth, A.J., and Heller S. (2003). Expression patterns of the RGS9?-1 anchoring protein R9AP in the chicken and mouse suggests multiple roles in the nervous system. Mol. Cell. Neurosci. 24, 687-695. Pubmed
Li, H., Liu, H., and Heller, S. (2003). Multipotent stem cells from the adult mouse inner ear. Nature Medicine 9, 1293-1299. Pubmed
Keresztes, G., Mutai, H., and Heller, S. (2003). TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. BMC Genomics 4, 24. Pubmed
Fuhrmann, S., Stark, M.R., and Heller, S. (2003). Expression of frizzled genes in the developing chick eye. Mech. Dev. Gene Expr. Pat. 3, 659-662. Pubmed
Heller, S., Bell, A., Denis, C.S., Choe, Y., and Hudspeth, A.J. (2002). Parvalbumin 3 is an abundant Ca2+ buffer in hair cells. J. Assoc. Res. Otolaryngol. 3, 488-498. Pubmed
Liedtke, W., Choe, Y., Marti-Renom, M.A., Bell, A.M., Denis, C.S., Sali, A.J. Hudspeth, A.J., Friedman, J.M., and Heller, S. (2000). Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103, 525-535. Pubmed
Robertson, N.G., Heller, S., Lin, J.S., Resendes, B.L., Weremowitz, S., Denis, C.S., Bell, A.M., Hudspeth, A.J. and Morton, C.C. (2000). A novel cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping. Genomics 66, 242-248. Pubmed
Robertson, N.G., Lu, L., Heller, S., Merchant, S.N., Eavey, R.D., McKenna, M., Nadol Jr, J.B., Miyamoto, R.T., Linthicum Jr, F.H., Neto, J.F.L., Hudspeth, A.J., Seidman, C.E., Morton, C.C. and Seidman, J.G. (1998). Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction. Nature Genetics 20, 299-303. Pubmed
Geissen, M., Heller, S., Pennica, D., Ernsberger, U. and Rohrer, H. (1998). The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling.
Development 125, 4791-4801. Pubmed
Fuhrmann, S., Heller, S., Rohrer, H. and Hofmann, H.-D. (1998). A transient role for ciliary neurotrophic factor in chick photoreceptor development.
J. Neurobiol. 37, 672-683. Pubmed
Fuhrmann, S., Kirsch, M., Heller, S., Rohrer, H. and Hofmann, H.-D. (1998). Differential regulation of ciliary neurotrophic factor-a expression in all major neuronal cell classes during development of the chick retina. J. Comp. Neurol. 400, 244-254. Pubmed
Heller, S., Sheane, C.A., Javed, Z. and Hudspeth, A.J. (1998). Molecular markers for cell types of the inner ear and candidate genes for hearing disorders.
Proc. Natl. Acad. Sci. USA 95, 11400-11405. Pubmed
Rosenblatt, K.P., Sun, Z.-P., Heller, S. and Hudspeth, A.J. (1997). Distribution of Ca2+-activated K+ channel isoforms along the tonotopic gradient of the chickens cochlea.
Neuron 19, 1061-1075. Pubmed
von Holst, A., Heller, S., Junghans, D., Geissen, M., Ernsberger, U. and Rohrer, H. (1997). Onset of CNTFR a expression and signal transduction during neurogenesis in chick dorsal root ganglia. Developmental Biology 191, 1-13. Pubmed
Heller, S., Huber, J., Finn, T.P., Nishi, R. and Rohrer, H. (1993). GPA and CNTF produce similar effects in sympathetic neurones but differ in receptor binding. Neuroreport 5, 357-360. Pubmed
Heller, S., Finn, T.P., Huber, J., Nishi, R., Geißen, M., Püschel, A.W. and Rohrer, H. (1995). Analysis of function and expression of the chick GPA receptor (GPAR alpha) suggests multiple roles in neuronal development. Development 121, 2681-2693. Pubmed
Reviews/Comments
Oshima, K. and Heller, S. (2005). Sound from silence. Nature Medicine 11, 249-250.
Rivolta, M.N., Li, H., and Heller, S. (2005). Generation of inner ear cell types from embryonic stem cells. Embryonic Stem Cells II: Methods and Protocols. Ed.: K. Turksen, Humana Press. In press.
Heller, S. (2004). Stem cells and gene therapy – are we expecting too much too soon? Hearing Health, 20, 10-15.
Steyger, P.S., Fekete, D.M., Heller, S., Schacht, J. and Yamoah, E.N. (2004) Research trends in cochlear development, physiology, dysfunction and bio-medical interventions. The Volta Review, Volume 104, Number 3, AG Bell Foundation, Washington DC.
Li, H., Corrales, C.E., Edge, A., and Heller, S. (2004). Stem cells in therapy for hearing loss. Trends in Mol Medicine 10, 309-315.
Mutai, H. and Heller, S. (2003). Vertebrate and invertebrate TRPV-like mechanoreceptors. Cell Calcium 33, 471-478.
Heller, S. (2002). Molecular screens for inner ear genes. J. Neurobiol. 53, 265-275.
Heller, S. (2002). Application of physiological genomics to the study of hearing disorders. J. Physiol. 543, 3-12..
Montell, C., Birnbaumer, L., Flockerzi, V., Bindels, R.J., Bruford, E.A., Caterina, M.J., Clapham, D.E., Harteneck, C., Heller, S., Julius, D., Mori, Y., Penner, R., Prawitt, D., Scharenberg, A.M., Schultz, G., Shimizu, N., Zhu, M.X. (2002). A unified nomenclature for the superfamily of TRP cation channels. Molecular Cell 9, 229-231.
Heller, S. and Hudspeth, A.J. (1998). Two deaf mice, two deaf mice... Murine candidate genes pinpoint the genetic bases of nonsyndromic hearing loss in humans. Nature Medicine 4, 560-561.
Heller, S, Ernsberger, U and Rohrer, H. (1996). Extrinsic signals in the developing nervous system: The role of neurokines during neurogenesis. Perspectives in Developmental Neurobiology 4, 19-34.
