Mathematical Modeling of Cochlear Biomechanics
Collaborators: Nikolas Blevins, MD, Sunil Puria PhD, Charles Steele PhD
We are designing a computational model of inner ear mechanics to understand the mechanisms that support the highly sensitivity, dynamic, and non-linear properties of normal hearing. This understanding will allow the functional characterization of alterations arising from a variety of cochlear disorders and from therapeutic interventions. We will develop an anatomically based three-dimensional computational model for the cochlea that incorporates the details of the micro-mechanics of the hair cells, neurons, supporting structures, membranes, and surrounding fluid environment. The model will be based on previous work by Dr. Steele in our group.
A systematic and comprehensive computational model of inner ear mechanics will provide the basis for addressing a number of clinically important issues. For example, we will be able to predict the mechanical effect of cochlear implant array placement, and how it may influence residual acoustic hearing in the implanted ear. Such data may help us to develop more effective acoustic-electric hybrid prostheses for individuals with high frequency hearing loss. Similarly, we will explore the mechanical sequellae of endolymphatic hydrops, and the degree to which this could contribute to hearing loss in Meniere’s disease. With the anticipated advent of micro-robotics, otologists will develop technology to manipulate the organ of Corti in an attempt to improve hearing. The benefit of this exciting future technology can only be fully realized if therapy is grounded a clear understanding of cochlear mechanics as will be provided by our project. Another important future technology for hearing restoration is the regeneration of cochlear sub structures through the introduction and differentiation of stem cells. The yet unknown mechanical consequences on hearing of these regenerative efforts can be explored in the proposed biomechanical framework.
