Dylan Chan, M.D., Ph.D., M.S.
Hometown: Huntington Beach, CA
Medical School: Cornell
Undergraduate: Yale
Other advanced degrees: Yale (MS),
The Rockefeller University (PhD)
E-mail: dylan.k.chan@gmail.com

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Current Projects
Injection of inner-ear stem cell spheres into mouse cochleae (with Stefan Heller, PhD)

Analysis of auditory phenotypes of a large cohort of Connexin 26 mutant genotypes (with Kay Chang, M.D.)
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Publications
Chan DK, Lieberman DM, Musatov S, Goldfein J, Selesnick SH, and Kaplitt MG (2006).  Protection against cisplatin-induced ototoxicity by AAV-mediated delivery of the X-linked inhibitor of apoptosis (XIAP) is not dependent on caspase inhibition. Otol Neurotol 28:417-425.
 
Asai Y, Chan DK, Starr CJ, Kappler JA, Kollmar R, and Hudspeth AJ (2006).  Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear.  Proc Natl Acad Sci USA 103:9069-9074.
 
Cooper LB, Chan DK, Roediger FC, Shaffer BR, Fraser JF, Musatov S, Selesnick SH, and Kaplitt MG (2006).  AAV-mediated delivery of the caspase inhibitor XIAP protects against cisplatin ototoxicity.  Otol Neurotol 27:484-490.
 
Hudspeth AJ and Chan DK (2006).  An experimental preparation of the mammalian cochlea that displays compressive nonlinearity in vitro.  In Auditory Mechanisms: Processes and Models.  Ed. Nuttall AL, Ren T, Gillespie P, Grosh K, and de Boer, E.  World Scientific:Singapore.  127-137.
 
Chan DK and Hudspeth AJ (2005).  Mechanical responses of the organ of Corti to acoustic and electrical stimulation in vitro.  Biophys J 89:4382-4395.
 
Chan DK and Hudspeth AJ (2005).  Ca2+ current-driven nonlinear amplification by the mammalian cochlea in vitro.  Nat Neurosci 8:149-155.
 
Eliezer D, Barre P, Kobaslija M, Chan D, Li X, and Heend L (2005).  Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation.  Biochemistry 44:1026-1036.
 
Kappler JA, Starr CJ, Chan DK, Kollmar R, and Hudspeth AJ (2004). A nonsense mutation in the gene encoding a zebrafish myosin VI isoform causes defects in hair-cell mechanotransduction.  Proc Natl Acad Sci USA 101:13056-13061.
 
Starr CJ, Kappler JA, Chan DK, Kollmar R, and Hudspeth AJ (2004). Mutation of the zebrafish choroideremia gene encoding Rab escort protein 1 devastates hair cells.  Proc Natl Acad Sci USA 101:2572-2577.
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Presentations
Chan DK, Lieberman DM, Musatov S, Selesnick SH, and Kaplitt MG (2006).  Protection against cisplatin-induced ototoxicity by AAV-mediated delivery of the X-linked inhibitor of apoptosis (XIAP) is not dependent on caspase inhibition.  Talk presented at the 139th Annual Meeting of the American Otologic Society.  Chicago, IL, May 2006.
 
Chan DK and Hudspeth AJ. Ca2+ current-driven nonlinear amplification by the mammalian cochlea in vitro.  Talk presented at the 28th Mid-Winter Research Meeting of the Association for Research in Otolaryngology.  New Orleans, LA, February 2005.
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Research Interests
Inner-ear physiology
Hair cell regeneration
Congenital hearing loss