One Diet Does Not Fit All: Weight Loss Study

The primary objective of this study is to determine if there is a genetic predisposition to being more successful in weight loss on a Low Fat vs. a Low Carb diet. In January 2013,  we started recruiting 600 participants for a 12-month weight loss study. We have enrolled over 560 participants to date and are beginning recruitment for our fifth and final cohort.  Classes for this group will begin in March 2015.

Eligible Partcipants

Eligible candidates for this study meet the following criteria:

  • Men and women in general good health
  • Under 50 years of age (women must be premenopausal)
  • Overweight
  • Interested in losing weight
  • Willing to be randomly assigned to follow either a Very Low-Fat or Very Low-Carbohydrate Diet for 12 months

Study Design

Extensive support and guidance will be provided by a team of health professionals, and both diets will emphasize high nutritional quality. Participants must be willing and able to come to the Stanford campus for multiple clinic visits and 22 classes over the 12-month period.


Analysis is currently underway.