Topic List : Genetics
Many breast cancer patients ‘undertested’
Physicians often fail to recommend genetic testing to breast cancer patients at high risk for cancer-associated mutations. Improving access to genetic counseling about the testing process and results is a key priority.
$10.5M in grants for encyclopedia of DNA
Stanford’s William Greenleaf, Michael Bassik, Michael Snyder, Jonathan Pritchard and Michael Cherry have won grants to work on the federally funded Encyclopedia of DNA Elements.
1 cent ‘lab on a chip’
Microfluidics, electronics and inkjet technology underlie a newly developed all-in-one biochip from Stanford that can analyze cells for research and clinical applications.
Researchers get $26.4 million for activity study
The medical school professors were awarded the grants as part of a large-scale National Institutes of Health program to study the biology of how physical activity improves health.
Child’s life saved by experimental drug
Four-year-old Zoe Harting is doing well after participating in a phase-2 clinical trial of the first drug for a deadly genetic disease, spinal muscular atrophy type 1.
Nusse wins $3 million Breakthrough Prize
The developmental biologist was honored for helping to decode how Wnt signaling proteins affect embryonic development, cancer and the activity of tissue-specific adult stem cells that repair damage after injury or disease.
Tracking cancer evolution in the blood
Monitoring cancer DNA in blood can predict recurrence and prognosis and drive treatment decisions. A Stanford study of 92 lymphoma patients suggests similar techniques may work for other tumors.
Paving the way for gene therapy
Using the CRISPR gene-editing technique in stem cells, Stanford researchers repaired the gene that causes sickle cell disease, and the mended stem cells were successfully transplanted into mice.
Gene therapy for blistering skin disease
A trial in which genetically altered skin was grafted onto patients’ chronic wounds marks the first time that skin-based gene therapy has been demonstrated to be safe and effective in humans.
Telomere destruction activates DNA damage response
A new study shows that telomeres shorten without cell division in a mouse model of Duchenne muscular dystrophy. Subsequent DNA damage responses and mitochondrial dysfunction are likely cause of heart failure.