Topic List : Stem Cells
Rat-grown pancreases help save diabetic mice
Growing organs from one species in the body of another may one day relieve transplant shortages. Now researchers show that islets from rat-grown mouse pancreases can reverse disease when transplanted into diabetic mice.
Fewer bone stem cells in diabetes impedes healing
Stanford researchers found that activating bone stem cells helps repair fractures in diabetic mice. Applying a protein to the fracture site increased the expression of key signaling proteins and enhanced healing in the animals.
Samuel Strober awarded $6.6 million
The California Institute for Regenerative Medicine awarded Samuel Strober, MD, $6.6 million to study a “deceptively simple” way to help kidney transplant recipients tolerate their new organ.
Stem cells police themselves to reduce scarring
Stem cells produce a decoy protein to attenuate growth signals. Artificially regulating this pathway might help keep muscles supple in muscular dystrophy or during normal aging, researchers hope.
Canine cancer immunotherapy
The work extends research by Stanford scientists who found that blocking CD47 might be useful in treating human cancer.
Paving the way for gene therapy
Using the CRISPR gene-editing technique in stem cells, Stanford researchers repaired the gene that causes sickle cell disease, and the mended stem cells were successfully transplanted into mice.
Fat cell-maturation hormone found
Mature fat cells produce a hormone that regulates the differentiation of nearby stem cells in response to glucocorticoid hormones and high-fat diets, Stanford researchers have found.
Dietary approach to depleting stem cells
A new study shows that a diet deficient in valine effectively depleted the blood stem cells in mice and made it possible to perform a blood stem cell transplantation on them.
Cell, gene medicine lab opens
Making cell- or virus-based therapies for use in humans requires a rigid set of quality-control standards outlined by the Food and Drug Administration. A new Stanford facility will allow promising new therapies to be tested in the clinic.
A safer way for bone marrow transplants
Scientists have devised a way to destroy blood stem cells in mice without using chemotherapy or radiotherapy, both of which have toxic side effects.