Researchers outline possible role of a deep brain structure in concussion

Through a combination of biometric tracking, simulated modeling and medical imaging, Stanford researchers have detailed how hits to the side of the head may cause concussion.

David Camarillo

Concussion researchers have long suggested that damage to the corpus callosum, a thick bundle of nerves that connects the brain’s two halves, could result in some common side effects of concussion, like dizziness or vision problems. The assumption is straightforward — that damage to the corpus callosum could affect coordination between the two halves — but difficult to prove.

Although still not proof, Stanford researchers have gathered evidence to support the idea by combining data from sensors worn by athletes, simulations of brain movement based on those measurements and brain images of people with and without concussions.

A paper describing the findings, published March 12 in Biomechanics and Modeling in Mechanobiology, suggests that impacts to the side of the head might cause harmful vibrations in a structure connected to the corpus collosum.

“Concussion is a big, vague term and we need to start breaking it down,” said former graduate student Fidel Hernandez, PhD, a lead author of the paper. “One way we can do that is to study individual structures that would be likely to cause traditional concussion symptoms if they were injured.”

Evaluation, three ways

This research is built on data from mouth guards worn by football players. Each mouth guard records head movement and acceleration in six directions through an integrated accelerometer and gyroscope. Analyzing 115 impacts recorded by these mouth guards, the researchers found two associated with concussion diagnoses. By applying the mouth guard measurements to a simulation of the neck, head and brain, the researchers saw instances in which the corpus callosum was pulled around by a structure above it called the falx.

The falx sits like a mohawk hairstyle between the brain’s two halves and is stiffer than the rest of the brain, like leather versus gelatin. Watching reproductions of the recorded impacts and additional simulations, the researchers saw that hits to the side of the head could produce vibrations in the falx, due to its stiffness. Those could then propagate down to the corpus callosum, creating the kind of tissue strain that is often implicated in concussion. Simulated strikes that made the head tilt toward the shoulder produced C-shape waves in the falx, while those that caused the head to turn produced S-shaped waves.

Michael Zeineh

Michael Zeineh, MD, PhD, assistant professor of radiology, and his lab assessed magnetic resonance imaging scans from two athletes who had been diagnosed with concussion. The researchers looked with the most sensitive method available — diffusion imaging — and found evidence of possible damage to the corpus callosum in their both brains.

Diffusion imaging is rarely used in clinical practice and, even with this advanced technology, the researchers only saw the corpus callosum abnormalities because they knew where to look and had a comparison group — scans from athletes from the same sport and with similar years of experience who had never been diagnosed with concussion.

“The bottom line is, when we do post-concussion brain scans in clinical settings, we don’t find anything. I’d say 95 percent of them are normal,” said Zeineh, a senior author of the paper. “Clinically, we interpret by eye, but the kinds of changes we’re showing in the paper, you can’t see with your eye. Concussion cannot be diagnosed by imaging alone.”

Given there were only two concussions in the data, the researchers emphasize the connection between side impacts, corpus callosum strain by the falx and concussion is still a hypothesis. A few previous studies have discounted this link, but none have combined biometric measurements, simulations and neuroimaging at this resolution. The researchers need more data to see how their hypothesis holds up and are already working with women’s lacrosse players and additional football players to obtain that.

“The neuroimaging is really important for confirming the simulated models, but it’s been difficult to get this combination of mouth guards and imaging,” said David Camarillo, PhD, assistant professor of bioengineering and a senior author of the paper. “Now, we can prove these things out in a more rigorous and larger sample size.”

Understanding what we’re up against

When someone is diagnosed with a concussion, the treatment is almost always the same. The problem is that there are likely many kinds of concussions with symptoms that depend on which part of the brain was injured and how badly.

“All concussions are not created equal,” Hernandez said. “We try to draw a line — a binary ‘yes concussion’ or ‘no’ — but concussions happen on a gradient.”

A more detailed understanding of concussions could lead to more tailored treatments and change how we prevent them, showing us, for example, which kinds of concussions are most damaging or easiest to avoid. This topic matters beyond sports, as many concussions are the consequence of falls, particularly in the elderly or very young. Car crashes carry concussion risk as well. So, not only could research like this help improve protective gear for football players and cyclists, it could inform safety standards for cars or suggest new ways to design safer homes.

Former postdoctoral scholar Chiara Giordano, PhD, and postdoctoral scholar Maged Goubran, PhD, are also lead authors of the paper. Medical resident Sherveen Parivash, MD, and professor of neurosurgery Gerald Grant, MD, are co-authors. 

Camarillo is a member of Stanford Bio-X, the Stanford Maternal & Child Health Research Institute and the Wu Tsai Neurosciences Institute at Stanford. Zeineh is a member of Bio-X and the Wu Tsai Neurosciences Institute.

This work was funded by the Maternal & Child Health Research Institute, the Lucile Packard Foundation for Children’s Health, the National Institutes of Health, the Radiology Society of North America and GE Healthcare.

Stanford’s Department of Bioengineering, which is jointly managed by the School of Medicine and School of Engineering, and the Department of Radiology also supported the work.



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