Teen awaiting heart-lung transplant first in western U.S. to undergo novel therapy

Listing Oswaldo Jimenez for a transplant was just the beginning. His doctors needed to perform what is referred to as a “bridge-to-transplant” solution, one that would sustain his organs until transplant could be done.

Oswaldo Jimenez (bottom, second from right), with his family and Carol Conrad, director of the pediatric heart-lung transplant program at Lucile Packard Children’s Hospital Stanford.
Samantha Dorman

2016 is starting off a whole lot better than last year did for 14-year-old Oswaldo Jimenez of Salem, Oregon.

Oswaldo was diagnosed with pulmonary arterial hypertension at age 9. In early 2015, his heart and lungs were failing, and a heart-lung transplant seemed to be his only real hope for survival.

Oswaldo was referred to doctors at Lucile Packard Children’s Hospital Stanford and Stanford Children’s Health, one of America’s leading centers for pediatric organ transplant. There, physicians determined that Oswaldo would indeed need a transplant, but that he could return home to Oregon to await notification of donor organs. But in the spring, Oswaldo’s condition rapidly worsened. He was admitted to a local hospital and emergency airlifted to Packard Children’s in May.

What happened? The pulmonary arterial hypertension made it hard for blood to flow properly through Oswaldo’s lungs, where blood picks up oxygen for the rest of the body. “The high blood pressure in his lungs was requiring his heart to pump harder and harder,” explained pediatric cardiologist Jeffrey Feinstein, MD, director of the Vera Moulton Wall Center for Pulmonary Vascular Disease and head of the hospital’s pediatric pulmonary hypertension program. “This eventually caused his heart to fail.”

“When we initially evaluated him a few months earlier, he had very few symptoms; when he returned, he could only walk a short distance before getting breathless,” added Feinstein, who is also a professor of pediatrics in the School of Medicine and the Dunlevie Family Professor of Pulmonary Vascular Disease. “The pressure in his lungs also caused two episodes of pulmonary hemorrhage. This bleeding into the lungs can be fatal.”

Leader in multi-organ transplantation

Combined heart and lung transplants are so rare that only 24 were performed in the United States in 2014. Stanford has long been a national leader in multi-organ transplantation, performing the world’s first successful combined heart-lung transplant, on an adult, at Stanford Hospital in 1981.

An illustration depicting the bridge-to-transplant system used on Jiminez.
Journal of Thoracic and Cardiovascular Surgery

Listing Oswaldo for transplant was just the beginning. Care teams wanted to ensure his failing heart and lungs could keep going until donor organs were available. They needed to perform what is referred to as a “bridge-to-transplant” solution, one that would sustain Oswaldo’s organs until transplant could be done.

“An integral element to success for children awaiting lung transplants is to keep them moving around,” said pediatric pulmonologist Carol Conrad, MD, director of the pediatric lung and heart-lung transplant program at the children’s hospital and an associate professor of pediatrics. “Being in good shape helps to make them good candidates for the transplant operation. Pre-operative debilitation leads to prolonged recovery period post-op and a poorer outcome in the long run.”

A novel procedure

It was then that doctors decided to try a novel procedure, one that would enable Oswaldo to be mobile. Called a pulmonary artery to left atrial shunt, it was a surgery that had been used only a dozen times in patients nationwide. It would reduce the workload on his failing heart, and allow Oswaldo to stay mobile and help oxygenate his blood while awaiting transplant.

Since the device was reasonably small, it allowed him to stay awake and mobile while awaiting transplant.

“He was so critically ill, and it was a very risky procedure; he was at high risk of cardiac arrest when being put to sleep for the surgery,” said Katsuhide Maeda, MD, surgical director of lung and heart-lung transplant program and a clinical assistant professor of cardiothoracic surgery. “But essentially, this shunt established a ‘lung’ that served to oxygenate his blood as it flowed through a box outside of his body. Since the device was reasonably small, it allowed him to stay awake and mobile while awaiting transplant.”

For parents Carmen Hernandez and Martin Jimenez, it was a difficult decision to go forward with this novel procedure, but there were no other options — and they trusted the team.

“We weren’t given any hope until we came here,” said Oswaldo’s mother, Carmen Hernandez, via a translator. “This seemed to give him the best chance to live.”

How it’s done

The procedure involved the insertion of a tube that redirected blood away from Oswaldo’s lungs into the oxygenator. This, in turn, provided oxygen to the blood and then returned it to his body, with his own heart providing the pump. The shunt device has been shown to sustain patients’ lives for several weeks to six months, depending mostly on whether complications such as bleeding, blood clots or stroke arose.

On July 12, Oswaldo made history by becoming the first child in the western United States to undergo this treatment. Then, just one week after receiving the shunt, donor organs became available. Oswaldo received his heart and lung transplant on July 19.

“We are so, so thankful for organ donation,” Carmen said. “During another family’s time of incredible grief, they gave my son the ultimate gift of life.”

Looking ahead

The post-operative period was complicated, but Oswaldo and his family returned home to Oregon in December. “He’s steadily improving,” said Conrad.

“There are no words to express our gratitude, and we can’t say enough about our medical team,” said his dad, Martin. “Once we arrived here, we knew we had the best and most experienced care possible.”

I want to run and play, and get my life back.

Added Carmen: “Now, the doctors can use this therapy to treat other patients. Maybe the next family faced with this won’t have such a hard decision to make, because it certainly worked for Oswaldo.”

Conrad said the hospital team likely will use this bridge-to-transplant treatment again, adding yet another option to the Stanford Medicine therapies and innovations for kids with failing hearts and lungs.

For Oswaldo, he is simply looking forward to being a kid again. “I want to run and play, and get my life back,” he said. As far as what the future holds?

“I just know I want to do something big in life,” he said.

Stanford Medicine integrates research, medical education and health care at its three institutions - Stanford University School of Medicine, Stanford Health Care (formerly Stanford Hospital & Clinics), and Lucile Packard Children's Hospital Stanford. For more information, please visit the Office of Communication & Public Affairs site at http://mednews.stanford.edu.

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