Palmer Lab Select Publications

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease. Hsieh CH, Shaltouki A, Gonzalez AE, Bettencourt da Cruz A, Burbulla LF, St. Lawrence E, Schüle B, Dimitri Krainc D, Palmer TD*, and Wang X.  In press 2016 Cell Stem Cells. *obtained funding, conceived, designed and interpreted experiments utilizing human iPSC-derived neurons, directed the activities of Palmer lab members Bettencourt da Cruz and St. Lawrence, participated in drafting the related portions of the manuscript and in manuscript revisions.

Aging-like Changes in the Transcriptome of Irradiated Microglia. Li MD, Burns TC, Kumar S, Morgan AA, Sloan SA, Palmer TD  Glia, 2015 May;63(5):754-67. doi: 10. 1002/glia.22782. Epub 2015 Feb 17. PMID: 25690519

The Relationship Between Serial [(18) F]PBR06 PET Imaging of Microglial Activation and Motor Function Following Stroke in Mice. Lartey FM, Ahn GO, Ali R, Rosenblum S, Miao Z, Arksey N, Shen B, Colomer MV, Rafat M, Liu H, Alejandre- Alcazar MA, Chen JW, Palmer TD*, Chin FT, Guzman R, Loo BW Jr, Graves E.  Mol Imaging Biol. 2014 Dec;16(6):821-9. PMID: 24865401 * provided technical support and participated in critical revision of the manuscript.

Stress and glucocorticoids promote oligodendrogenesis in adult hippocampus. Chetty S, Friedman AR, Kereshmeh T-L, Kirby ED, Mirescu C, Guo F, Krupik D, Nichoas A, Geraghty A, Krishnamurthy A, Tsai M-K, Covarrubias D, Wong, A, Francis D, Sapolsky RM, Palmer TD*, Pleasure D, Kaufer D:  Mol Psychiatry. 2014 Feb 11. doi: 10.1038/mp.2013.190. PMID:24514565 *this manuscript details work initiated by senior author Kaufer while a postdoctoral fellow in the Palmer lab. The project was completed after Kaufer was recruited to UC Berkeley as an assistant professor. Palmer obtained funding, substantially designed the proof of principle experiments and continued to provide intellectual and technical guidance in the completion of the project and final manuscript revisions.

Stereotypical Alterations in Cortical Patterning are associated with Maternal Illness-induced Placental Dysfunction. Carpentier PA, Haditsch U, Braun AE, Cantu AV, Moon HM, Price RO, Anderson M, Saravanapandian V, Ismail K, Rivera M, Weimann J, Palmer TD.  J Neurosci. 2013 Oct 23;33(43):16874-88. doi: 10.1523/JNEUROSCI.4654- 12.2013. PMID:24155294

Natural Killer Cell-Activating Receptor NKG2D Mediates Innate Immune Targeting of Allogeneic Neural Progenitor Cell Grafts. Phillips LK, Gould EA, Babu H, Krams SM, Palmer TD*. Martinez OM.  Stem Cells 2013 Jun 4. Doi 10,1002/stem. 1422  *co-senior and co-corresponding author, designed all experiments related to neural progenitor cell transplantation, co-advisor for first author Phillips, wrote the manuscript with Phillips, and Martinez and participated extensively in manuscript revisions and re-submissions.

Differential roles of TNFR1 and TNFR2 signaling in adult hippocampal neurogenesis. Chen Z, Palmer TD.  Brain Behav Immun. 2013 May;30:45-53. doi: 10.1016/j.bbi.2013.01.083. Epub 2013 Feb 9. PMID: 23402793

Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/β-catenin-responsive neural stem cells. Bowman AN, van Amerongen R, Palmer TD*, Nusse R.  Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7324-9. doi: 10.1073/pnas.1305411110. Epub 2013 Apr 15. PMID: 23589866 *participated extensively in advising first author Bowman, contributed to experimental design, data analysis and interpretation, contributed substantially to manuscript revisions and intellectual content related to neural stem cell biology.

PET Imaging of Stroke-Induced Neuroinflammation in Mice Using [18F] PBR06. Lartey FM, Ahn GO, Shen B, Cord KT, Smith T, Chua JY, Rosenblum S, Liu H, James ML, Chernikova S, Lee  SW, Pisani LJ, Tirouvanziam R, Chen JW, Palmer TD*, Chin FT, Guzman R, Graves EE, Loo BW Jr.  Mol Imaging Biol. 2013 Jul 9. [Epub ahead of print] PMID: 23836504 *provided technical guidance and interpreted data generated in the histological analysis of neuroinflammation.

Neuronal Rac1 Is Required for Learning-Evoked Neurogenesis Journal of Neuroscience Haditsch, U., Anderson, M. P., Freewoman, J., Cord, B., Babu, H., Brakebusch, C., Palmer, T. D. 2013; 33 (30): 12229-12241

Absence of CCL2 is sufficient to restore hippocampal neurogenesis following cranial irradiation. Brain Behavior and Immunity Lee S. W., Haditsch U., Cord B. J., Guzman R., Kim S. J., Boettcher C., Priller J., Ormerod B. K., Palmer T. D. 2013; 30: 33-44

Differential roles of TNFR1 and TNFR2 signaling in adult hippocampal neurogenesis. Brain Behavior and Immunity Chen, Z., Palmer, T. D. 2013; 30: 45-53

Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/ß-catenin-responsive neural stem cells. Proceedings of the National Academy of Sciences of the United States of America Bowman, A. N., van Amerongen, R., Palmer, T. D., Nusse, R. 2013; 110 (18): 7324-7329

PPAR gamma activation prevents impairments in spatial memory and neurogenesis following transient illness. Brain Behavior and Immunity Ormerod B. K., Hanft S. J., Asokan A., Haditsch U., Lee S. W., Palmer T. D. 2013; 29: 28-38

PET Imaging of Stroke-Induced Neuroinflammation in Mice Using [(18)F]PBR06. Molecular imaging and biology Lartey, F. M., Ahn, G. O., Shen, B., Cord, K. T., Smith, T., Chua, J. Y., Rosenblum, S., Liu, H., James, M. L., Chernikova, S., Lee, S. W., Pisani, L. J., Tirouvanziam, R., Chen, J. W., Palmer, T. D., Chin, F. T., Guzman, R., Graves, E. E., Loo, B. W. 2013

Adult neural progenitor cells reactivate superbursting in mature neural networks Experiemental Neurology Stephens C. L., Toda H., Palmer T. D., DeMarse T. B., Ormerod B. K. 2012; 234 (1): 20-30

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome Nature Medicine Pasca S. P., Portmann T., Voineagu I., Yazawa M., Shcheglovitov A., Pasca A. M., Cord B., Palmer T. D., Chikahisa S., Nishino S., Bernstein J. A., Hallmayer J., Geschwind D. H., Dolmetsch R. E. 2011; 17 (12): 1657-U176

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate alpha-Synuclein and Are Susceptible to Oxidative Stress PLOS One Byers B., Cord B., Ha Nam Nguyen H. N., Schuele B., Fenno L., Lee P. C., Deisseroth K., Langston J. W., Pera R. R., Palmer T. D. 2011; 6 (11)

The CCR2/CCL2 Interaction Mediates the Transendothelial Recruitment of Intravascularly Delivered Neural Stem Cells to the Ischemic Brain STROKE Andres R. H., Choi R., Pendharkar A. V., Gaeta X., Wang N., Nathan J. K., Chua J. Y., Lee S. W., Palmer T. D., Steinberg G. K., Guzman R. 2011; 42 (10): 2923-U387

Placental TNF-alpha Signaling in Illness-Induced Complications of Pregnancy American Journal of Pathology Carpentier P. A., Dingman A. L., Palmer T. D. 2011; 178 (6): 2802-2810

MHC Mismatch Inhibits Neurogenesis and Neuron Maturation in Stem Cell Allografts PLOS ONE Chen Z., Phillips L. K., Gould E., Campisi J., Lee S. W., Ormerod B. K., Zwierzchoniewska M., Martinez O. M., Palmer T. D. 2011; 6 (3)

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell stem cell Nguyen H. N., Byers B., Cord B., Shcheglovitov A., Byrne J., Gujar P., Kee K., Schüle B., Dolmetsch R. E., Langston W., Palmer T. D., Pera R. R. 2011; 8 (3): 267-280

Transplanted Stem Cell-Secreted Vascular Endothelial Growth Factor Effects Poststroke Recovery, Inflammation, and Vascular Repair Stem Cells Horie N., Pereira M. P., Niizuma K., Sun G., Keren-Gill H., Encarnacion A., Shamloo M., Hamilton S. A., Jiang K., Huhn S., Palmer T. D., Bliss T. M., Steinberg G. K. 2011; 29 (2): 274-285

A protocol for isolation and enriched monolayer cultivation of neural precursor cells from mouse dentate gyrus. Frontiers in neuroscience Babu H., Claasen J., Kannan S., Rünker A. E., Palmer T., Kempermann G. 2011

Transplanted Stem Cell-Secreted VEGF Effects Post-Stroke Recovery, Inflammation, and Vascular Repair. Stem cells (Dayton, Ohio) Horie N., Pereira M. P., Niizuma K., Sun G., Keren-Gill H., Encarnacion A., Shamloo M., Hamilton S. A., Jiang K., Huhn S., Palmer T. D., Bliss T. M., Steinberg G. K. 2011

Characterization of axon guidance cue sensitivity of human embryonic stem cell-derived dopaminergic neurons Molecular and Cellular Neuroscience Cord B. J., Li J., Works M., McConnell S. K., Palmer T., Hynes M. A. 2010; 45 (4): 324-334

Mitochondrial Protection Attenuates Inflammation-Induced Impairment of Neurogenesis In Vitro and In Vivo Journal of Neuroscience Voloboueva L. A., Lee S. W., Emery J. F., Palmer T. D., Giffard R. G. 2010; 30 (37): 12242-12251

Murine Embryonic Stem Cell-Derived Pyramidal Neurons Integrate into the Cerebral Cortex and Appropriately Project Axons to Subcortical Targets Journal of Neuroscience Ideguchi M., Palmer T. D., Recht L. D., Weimann J. M. 2010; 30 (3): 894-904

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