Research

The Brain Metastases Consortium facilitates collaborative research between the many exceptional researchers and clinicians at Stanford University. These projects involve specialists from different departments, whose synergistic talents and interests when combined, exponentially advance our understanding of, and capacity to treat, metastatic brain tumors. Interests include cancer biology, radiation oncology, neuroscience, immunology, medical oncology, neurosurgery, physics, bio-engineering, neuro oncology, and population science, among others. 

Publications

Featured Publications:

Response of a pre-clinical model of breast cancer leptomeningeal disease to the novel, brain-permeant chemotherapeutic QBS10072S.

Authors: Deng J, Chernikova S, Wang Y, Rodriguez M, Anderson SJ, Umeh-Garcia MC, Godfrey BO, Ahmadian SS, Fischer WN, Koller KJ, Jandeleit B, Ringold G, Hayden Gephart M. 

Published: Molecular Cancer Therapeutics, October 2021

Comprehensive RNA analysis of CSF reveals a role for CEACAM6 in lung cancer leptomeningeal metastases.

Authors: Li Y, Polyak D, Lamsam L, Connolly I, Johnson E, Khoeur L, Stanley G, Zhang Y, Liu B, Nagpal S, Hayden Gephart M. 

Published: Nature Precision Oncology, October 2021

 

Financial toxicity in patients with brain and spine metastases.
Authors: Koenig JL, Sandhu N, Sborov K, Sabloch A, Usoz M, Li G, Hayden Gephart M, Chang S, Hiniker S, Soltys SG, Pollom EL.
Published: World Neurosurgery, July 2021

Improved survival and disease control following pembrolizumab-induced immune-related adverse events in high PD-L1 expressing non-small cell lung cancer with brain metastases.
Authors: Zhang M, Rodrigues AJ, Pollom EL, Gibbs IC, Soltys SG, Hancock SL, Neal JW, Padda SK, Ramchandran KJ, Wakelee HA, Chang SD, Lim M, Hayden Gephart M, Li G.  
Published: Journal of Neuro Oncology, March 2021

 

Clinical Trials

We currently have several recruiting trials testing the efficacy and safety of a variety of therapies for brain metastases. 

Search Our Clinical Trials

Featured Trial:

Hyperpolarized Carbon C 13 Pyruvate Magnetic Resonance Spectroscopic Imaging in Detecting Lactate and Bicarbonate in Participants With Central Nervous System Tumors

This early phase I trial studies how well hyperpolarized carbon C 13 pyruvate magnetic resonance imaging works in detecting lactate and bicarbonate in participants with central nervous system tumors. Hyperpolarized carbon C 13 pyruvate magnetic resonance imaging may be used to measure the metabolic state of malignant brain tumors.