Juliet Knowles, MD, PhD


BA, University of Texas-Austin, Biology and Philosophy
PhD, Stanford University, Neuroscience
MD, Stanford University


  • Neurotrophins

  • Neuroprotective strategies Alzheimer's disease and other neurodegenerative diseases

  • Epilepsy


Knowles JK, Simmons DA, Nguyen T-V, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter M, Wyss-Coray T, Massa SM, Longo FM. A small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer’s mouse model. Neurobiology of Aging, in press.
Knowles JK, Penn AA. Perinatal Brain Development, Malformation and Injury. Morgan and Claypool Life Sciences Colloquium Series on the Developing Brain, 2012.

Knowles JK, Rajadas J, Vander Griend L, Ishikawa C, Nguyen T, LeMieux M, Wyss-Coray T, Longo FM. The p75 neurotrophin receptor promotes amyloid-β(1-42) induced neuritic dystrophy in vitro and in vivo. The Journal of Neuroscience, August 26, 2009.

Yang T*, Knowles JK*, Lu Q, Zhang H, Arancio O, Moore L, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller G, Xie Y,  Massa SM,  Longo FM. Small molecule, non-peptide p75NTR ligands inhibit Aβ-induced neurodegeneration and synaptic impairment. PLoS ONE, Oct 2008.
*co first authors

Longo FM, Yang T, Knowles JK, Xie Y, Moore LA, Massa SM. Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms. Curr Alzheimer Res. 2007 Dec;4(5):503-6.

Prip-Buus C, Thuillier L, Abadi N, Prasad C, Dilling L, Klasing J, Demaugre F, Greenberg CR, Haworth JC, Droin V, Kadhom N, Gobin S, Kamoun P, Girard J, Bonnefont JP. Molecular and enzymatic characterization of a unique carnitine palmitoyltransferase 1A mutation in the Hutterite community. Mol Genet Metab. 2001 May;73(1):46-54.


Best research poster, 2013 Stanford Neuroscience Research Forum

Northern California Alzheimer’s Association Outstanding Young Scientist Award, 2009.

NRSA F30 grant entitled “p75NTR-mediated protection from amyloid neurodegeneration” funded by National Institute of Neurological Disease and Stroke, 2006-2009.

Research Scholarship, American Academy of Neurology (AAN), 2004