Jack Tzu-Chieh Wang, MD PhD

EDUCATION AND TRAINING:

Fellowship: Stanford University Medical Center, Dept. of Neurology, Neurocritical Care (2018-2020)
Residency: University of California at Los Angeles, Neurology (2018)
Internship: Kaiser Permanente Santa Clara, Internal Medicine (2015)
Medical Education: Medical Scientist Training Program (MSTP), Stanford School of Medicine
MD, Stanford School of Medicine, Medicine (2014)
PhD, Stanford School of Medicine, Neuroscience (2014)
Undergraduate: Stanford University; BS Biological Sciences, BA Psychology (2003)

CERTIFICATIONS:

Board Certification: Neurology, American Board of Psychiatry and Neurology (2018)

INTERESTS:

  • Clinical: Neurocritical Care, Stroke, Neurotrauma
    •    Clinical and imaging predictors of outcome in traumatic brain + spinal cord injuries.
  • Translational:
    • Molecular mechanisms of axonal/Wallerian degeneration following injury.
    • Identifying therapeutic targets to delay or reverse nerve degeneration.
    • Novel molecular & cellular approaches to promote CNS regeneration.
    • Modulating neuronal and glial interactions to enhance stroke recovery.
       

SELECTED PEER-REVIEWED PUBLICATIONS:

Wang JT, Medress ZA, Vargas ME, and Barres BA. (2015). Local Axonal Protection by WldS as Revealed by Conditional Regulation of Protein Stability. Proceedings of the National Academy of Sciences. 112(33): 10093-100

Winzeler A and Wang JT. (2013). Purification and Culture of Retinal Ganglion Cells from Rodents. Cold Spring Harb Protoc. Jul1;2013(7)

Winzeler A and Wang JT. (2013). Culturing Hybridoma Cell Lines for Monoclonal Antibody Production. Cold Spring Harb Protoc. Jul1;2013(7).

Völgyi B, Pan F, Paul DL, Wang JT, Huberman AD, Bloomfield SA. (2013). Gap junctions are essential for generating the correlated spike activity of neighboring retinal ganglion cells. PLoS One. 23;8(7):e69426

Wang JT, Medress ZA, and Barres BA (2012). Axon Degeneration: Molecular Mechanisms of a Self-Destructive Pathway. Journal of Cell Biology. 196(1):7-18.

Wang JT, Kunzevitzky N, Dugas JC, Cameron M, Barres BA, Goldberg JL. (2007). Disease gene candidates revealed by expression profiling of retinal ganglion cells development. Journal of Neuroscience. 27(32): 8593-603.

Goldberg JL, Vargas ME, Wang JT, Mandemakers W, Oster SF, Sretavan DW, Barres BA. (2004). An oligodendrocyte lineage-specific semaphorinm Sema5A, inhibits axon growth by retinal ganglion cells. Journal of Neuroscience. 24(21): 4989-99.

Book Chapters:

Winzeler A and Wang JT. Purification and Culture of Retinal Ganglion Cells. Barres BA, Stevens B (eds). Purifying and Culturing Neural Cells. Cold Spring Harbor Laboratory Press. NY. 2013.

Invited Talks:

Molecular Mechanisms of Wlds and SARM1 Mediated Protection in Stroke. Selected abstract discussion speaker, American Academy of Neurology Annual Conference, Los Angeles, CA. April 25, 2018

What is the Molecular Mechanism of Axon Degeneration in Stroke? Symposium organizer and speaker, American Society of Neurochemistry Annual Conference, Riverside, CA. March 26, 2018

Published Abstracts:

Wang JT, Putman J, Carmichael T, and Hinman JD (2018). Molecular Mechanisms of WldS and SARM1 Mediated Protection in Stroke. American Academy of Neurology Annual Meeting.

Wang JT, Putman J, Carmichael T, and Hinman JD (2018). Protection from Ischemic Injury by Delaying Wallerian Degeneration. American Society of Neurochemistry Annual Meeting.

Wang JT, Medress ZA, and Barres BA (2011). Mechanisms of Local Axonal Protection by Wlds Through Regulation of Protein Stability. International Workshop on Molecular Mechanisms of Axon Degeneration.

Wang JT, Medress ZA, and Barres BA (2010). Local Axonal Protection by Wlds as Revealed by Conditional Regulation of Protein Stabilization. Society for Neuroscience.

Wang JT, Barres BA. Wlds axon protection is a local event in the axon and does not require mitochondrial activity (2010). International Workshop on Molecular Mechanisms of Axon Degeneration.

Wang JT, Vargas ME, and Bares BA (2008). Protein Phosphatase 2A and its Role in Regulating Axonal Neurofilament Sensitivity to Degradation During Axonal Degeneration. Society for Neuroscience.

Wang JT, Vargas ME, and Barres BA (2007). Functional Genomic Analysis of Wlds Retinal Ganglion Cells. Society for Neuroscience.

Wang JT, Vargas ME, and Barres BA (2007). What is the Mechanism of Wlds-mediated Axon Protection?  International Symposium on Neural Regeneration.

Wang JT and Barres BA (2007). How Do Cyp1b1 Mutations Cause Glaucoma? Howard Hughes Medical Institute Symposium.

HONORS/AWARDS:

Los Angeles Neurological Society Excellence in Research Award (2018)

Best Poster & Presentation, UCLA-Semel Neuroscience Institute Research Symposium (2018)

NINDS R25 Translational Neuroscience Research Grant (2016-2020)

Stanford University Bio-X Bowes Research Fellow (2011-2014)

Best Poster Award, Stanford Institute of Neuroscience Symposium (2010)

American Heart/Stroke Association Pre-doctoral Research Fellowship (2009-2011)

Adelson Neural Repair & Rehabilitation Research Fellowship (2007-2009)

Johnson & Johnson Translational Neuroscience Research Scholar (2007-2009)

Student Delegate, International Achievement Summit (2007)

Howard Hughes Medical Institute Medical Research Fellow (2006-2007)

Stanford Medical Scholars Research Fellow (2005-2007)

Excellence in Undergraduate Teaching (2003)