The Stanford Neuro-Oncology Program Adult Clinical Trials

Recurrent High Grade Glioma

Phase II/III Randomized Study of Toca 511 & Toca FC Versus SOC in Subjects Undergoing Surgery for Recurrent GBM/AA
PI: Seema Nagpal
Clinicaltrials.gov#: NCT02414165

A Phase I BPM31510 + Vitamin K in High Grade Glioma that has Recurred on Bevacizumab Containing Regimen
PI: Seema Nagpal
Clinicaltrials.gov#: NCT03020602

Brain Metastases

A Pilot Study to Assess Lactate and Bicarbonate Detection Within Malignant Brain Tumors Using [1-13C]-Pyruvate DNP Magnetic Resonance Spectroscopy (MRS)
PI: Lawrence Recht
Clinicaltrials.gov#: NCT03565367

Newly Diagnosed Glioma

Phase 1/2 trial to evaluate safety, immunogenicity and preliminary efficacy of INO-5401 and INO-9012 in combination with cemiplimab (REGN2810), with radiation and chemotherapy, in subjects with newly-diagnosed glioblastoma (GBM)
PI: Seema Nagpal
Clinicaltrials.gov#: NCT03491683

CNS Diagnostic Imaging

Phase I/II, Open-Label Study Evaluating the Efficacy and Pharmacokinetics of Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Neoplasms during Neurosurgical Procedure
PI: Gordon Li
Clinicaltrials.gov#: NCT03510208

A Phase I Study of [18F]DASA-23 as a PET Tracer for Evaluating Pyruvate Kinase M2 (PKM2) Expression in Healthy Volunteers and in Patients with Intracranial Tumors
PI: Sanjiv Gambhir
Clinicaltrials.gov#: NCT03539731

A Pilot Study to Assess Lactate and Bicarbonate Detection Within Malignant Brain Tumors Using [1-13C]-Pyruvate DNP Magnetic Resonance Spectroscopy (MRS)
PI: Lawrence Recht
Clinicaltrials.gov#: NCT03565367

Brain Tumors: Other

Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma
PI: Scott Soltys
Clinicaltrials.gov#: NCT03180268